Product image of Idisan (Icatibant) supplied by GNH India

Idisan

Active Ingredient:
Icatibant
Origin:
EU

Idisan (Icatibant)

Icatibant, the active ingredient in Idisan, is a bradykinin B2 receptor antagonist presented as a subcutaneous solution for subcutaneous use. It is indicated for the treatment of hereditary angioedema attacks in patients with a confirmed diagnosis.

GNH India supplies Idisan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches for global distribution. Clients benefit from reliable logistics and comprehensive documentation.

Manufacturer / TM Owner

Norameda Uab

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Indications & Clinical Uses

Idisan is used to manage acute episodes within the hereditary angioedema (HAE) disease pathway.

  • Hereditary angioedema (HAE) attacks: rapid reduction of swelling and improvement of airway patency.
  • Hereditary angioedema type I: alleviates edema during acute crises.
  • Hereditary angioedema type II: controls sudden swelling episodes.

How It Works

  • Icatibant selectively and competitively blocks the bradykinin B2 receptor, preventing bradykinin‑induced vasodilation and increased vascular permeability. By inhibiting this pathway, the drug reduces the fluid extravasation that causes the characteristic swelling of hereditary angioedema.

Side Effects

Common and serious adverse reactions have been reported with subcutaneous icatibant administration.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Redness or swelling at injection site: localized erythema.
  • Nausea: occasional feeling of queasiness.
  • Headache: transient head discomfort.
  • Dizziness: brief episodes of light‑headedness.

Serious or Rare Side Effects

  • Hypersensitivity reactions: rash, urticaria, or anaphylaxis.
  • Severe hypotension: marked drop in blood pressure.
  • Angioedema paradoxically: swelling of face, lips, or airway.
  • Thrombocytopenia: low platelet count.
  • Acute myocardial infarction: rare cardiac event.

Precautions & Warnings

Before prescribing Idisan, clinicians should consider several precautionary measures.

  • Confirm diagnosis of hereditary angioedema: ensure appropriate indication.
  • Assess for known hypersensitivity to icatibant or excipients: avoid use if present.
  • Monitor cardiovascular status: use cautiously in patients with unstable heart disease.
  • Evaluate pregnancy and lactation status: risk unknown, weigh benefits and risks.
  • Review concomitant ACE inhibitor therapy: consider alternative due to increased bradykinin risk.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Icatibant may interact with other medicines that affect the bradykinin pathway or cardiovascular system.

Major Interactions (Avoid)

  • ACE inhibitors: increased risk of angioedema.
  • Angiotensin receptor blockers (ARBs): potential additive bradykinin effects.
  • Other bradykinin B2 receptor antagonists: may reduce efficacy.

Moderate Interactions (Monitor Closely)

  • Estrogen‑containing oral contraceptives: may exacerbate HAE symptoms.
  • Hormone replacement therapy: monitor for swelling episodes.
  • Diuretics: watch for changes in blood pressure.

Frequently Asked Questions

Idisan contains icatibant and is indicated for the treatment of acute hereditary angioedema (HAE) attacks in patients with a confirmed diagnosis of HAE.

Icatibant is a selective competitive antagonist of the bradykinin B2 receptor. By blocking this receptor, it prevents bradykinin‑mediated vasodilation and increased vascular permeability, thereby reducing swelling during HAE attacks.

The dosage and administration schedule are determined by the prescribing healthcare professional based on the patient’s condition and applicable regulatory guidelines.

The safety of icatibant in pregnancy and lactation has not been established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and the necessary import documentation.

The primary alternative for HAE is C1‑esterase inhibitor replacement. Idisan (icatibant) provides a targeted bradykinin B2 receptor blockade and is administered subcutaneously, offering rapid symptom relief without the need for plasma‑derived products.

Idisan should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use.

Idisan is given as a subcutaneous injection, typically into the abdomen or thigh, by a trained healthcare professional using aseptic technique.

Serious adverse events include hypersensitivity reactions such as anaphylaxis, severe hypotension, and paradoxical angioedema. Patients should be monitored for these signs after injection.

Idisan is contraindicated in individuals with known hypersensitivity to icatibant or any of its excipients. Caution is advised for patients with unstable cardiovascular disease or those receiving ACE inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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