Product image of Idroquark (Hydrochlorothiazide, Ramipril) supplied by GNH India

Idroquark

Active Ingredient:
Hydrochlorothiazide, Ramipril
Origin:
EU

Idroquark (Hydrochlorothiazide, Ramipril)

Hydrochlorothiazide and Ramipril, the active ingredients in Idroquark, are a thiazide diuretic and an ACE inhibitor presented as an oral tablet for adult use. They treat hypertension and are used as adjunct therapy in patients with heart failure.

GNH India supplies Idroquark as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product meets EU quality standards and our supply chain ensures timely delivery and supports clinical programs across multiple regions.

Manufacturer / TM Owner

Polifarma S.P.A

1
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Indications & Clinical Uses

  • Idroquark is indicated for conditions within the cardiovascular disease spectrum where blood pressure control is required.
  • Hypertension: lowers systolic and diastolic pressure, reducing cardiovascular risk.
  • Heart failure: used as adjunct therapy to decrease preload and afterload, aiding symptom control.
  • Diabetic nephropathy: helps manage hypertension and may slow progression of renal impairment.

How It Works

  • Hydrochlorothiazide blocks sodium‑chloride reabsorption in the distal convoluted tubule, increasing urinary excretion of water and electrolytes, which reduces plasma volume. Ramipril inhibits angiotensin‑converting enzyme, decreasing angiotensin II formation, leading to vasodilation and reduced aldosterone secretion. The combined actions produce additive blood‑pressure‑lowering effects through volume reduction and vascular relaxation.

Side Effects

Idroquark may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Increased urinary frequency
  • Electrolyte disturbances such as low potassium or sodium
  • Cough
  • Mild fatigue

Serious or Rare Side Effects

  • Angioedema (swelling of face, lips, tongue)
  • Severe hypotension leading to fainting
  • Acute renal failure or marked rise in serum creatinine
  • Hyperkalemia (dangerously high potassium levels)
  • Blood dyscrasias such as agranulocytosis

Precautions & Warnings

  • Before initiating Idroquark, clinicians should consider several safety measures.
  • Monitor blood pressure: regular checks to avoid excessive hypotension.
  • Assess renal function: periodic serum creatinine and eGFR measurements.
  • Check electrolytes: especially potassium and sodium levels.
  • Avoid use in pregnancy: category D, potential fetal harm.
  • Use caution in elderly: increased sensitivity to blood‑pressure changes.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Idroquark can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics: risk of hyperkalemia.
  • Aliskiren in diabetic patients: increased renal adverse events.
  • Lithium: may raise lithium concentrations, leading to toxicity.

Moderate Interactions (Monitor Closely)

  • NSAIDs: can blunt antihypertensive effect and impair renal function.
  • Other antihypertensives: additive hypotensive effect.
  • Corticosteroids: may increase urinary potassium loss.

Frequently Asked Questions

Idroquark is prescribed for patients who need blood‑pressure control, primarily for hypertension and as an adjunct in heart‑failure management. It may also be used in diabetic kidney disease to help control blood pressure and protect renal function.

Hydrochlorothiazide increases urine output by inhibiting sodium‑chloride reabsorption, lowering plasma volume. Ramipril blocks the conversion of angiotensin I to angiotensin II, causing vasodilation and reducing aldosterone. Together they lower blood pressure through complementary mechanisms of volume reduction and vascular relaxation.

The specific dose of Idroquark is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and other individual factors. Dosage adjustments are made according to clinical guidelines and patient monitoring.

Idroquark is classified as pregnancy category D, indicating evidence of fetal risk, and it should be avoided unless the potential benefit justifies the risk. Use while breastfeeding is not recommended because the drugs can pass into breast milk and affect the infant.

To place an order, submit an enquiry on the Idroquark product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑agent therapies, Idroquark offers the convenience of two complementary mechanisms in one tablet, often achieving better blood‑pressure control than either component alone. It may reduce the need for multiple pills, but clinicians must consider individual tolerability and interaction profiles when choosing therapy.

Idroquark should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from excess moisture and direct sunlight to maintain stability and potency throughout its shelf life.

Idroquark is taken orally, usually once daily or as directed by the prescriber. It should be swallowed whole with a glass of water, and patients are advised to follow any specific timing recommendations related to meals or other medications.

The most serious risks include angioedema, which can cause swelling of the face or throat, severe hypotension that may lead to fainting, acute kidney injury, and dangerous elevations in blood potassium levels. Patients should seek immediate medical attention if they experience any of these symptoms.

Idroquark is contraindicated in patients with known hypersensitivity to either component, those with severe renal impairment, hyperkalemia, or a history of angioedema related to ACE‑inhibitor therapy. It should also be avoided in pregnant women and used with caution in the elderly.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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