Product image of Idrossiclorochina Doc (Hydroxychloroquine Sulfate) supplied by GNH India

Idrossiclorochina Doc

Active Ingredient:
Hydroxychloroquine Sulfate
Origin:
EU

Idrossiclorochina Doc (Hydroxychloroquine Sulfate)

Hydroxychloroquine, the active ingredient in Idrossiclorochina Doc, is an antimalarial presented as an oral tablet for oral use. It is employed to treat malaria and to manage autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus in adult patients.

GNH India supplies Idrossiclorochina Doc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Doc Generici S.R.L.

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Indications & Clinical Uses

Hydroxychloroquine is an antimalarial and immunomodulatory agent used in several autoimmune conditions.

  • Malaria: treats acute uncomplicated malaria caused by susceptible Plasmodium species.
  • Rheumatoid arthritis: reduces joint inflammation and disease activity.
  • Systemic lupus erythematosus: helps control disease flares and cutaneous manifestations.

How It Works

  • Hydroxychloroquine accumulates in lysosomes, raising the internal pH and inhibiting lysosomal activity and autophagy. This interferes with antigen processing and presentation, modulating the immune response. It also blocks Toll‑like receptor signaling, reducing cytokine production and dampening inflammatory pathways.

Side Effects

Hydroxychloroquine may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Diarrhea: loose stools, often transient.
  • Skin rash: erythematous or pruritic lesions.
  • Headache: mild to moderate intensity.
  • Visual disturbances: blurred vision or difficulty focusing.
  • Loss of appetite: reduced food intake.

Serious or Rare Side Effects

  • Retinopathy: progressive vision loss requiring ophthalmologic monitoring.
  • Cardiac toxicity: QT interval prolongation and arrhythmias.
  • Severe hypersensitivity: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor appropriately.

  • Baseline eye exam: assess retinal health prior to treatment.
  • Cardiac assessment: evaluate QT interval in patients with cardiac risk.
  • Renal function: adjust use in severe renal impairment.
  • Pregnancy: weigh potential risks and benefits; consult obstetric guidance.
  • Concomitant drugs: review for interactions that may increase toxicity.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Hydroxychloroquine can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • QT‑prolonging agents (e.g., quinidine, amiodarone): increased risk of arrhythmia.
  • Antacids containing aluminum or magnesium: reduce absorption of hydroxychloroquine.
  • Cytochrome P450 inhibitors (e.g., ketoconazole): may raise plasma concentrations.

Moderate Interactions (Monitor Closely)

  • CYP2D6 substrates (e.g., metoprolol): possible altered metabolism.
  • Insulin or oral hypoglycemics: enhanced hypoglycemic effect.
  • Digoxin: potential increase in serum levels.

Frequently Asked Questions

Idrossiclorochina Doc, containing hydroxychloroquine, is prescribed for the treatment of malaria and for managing autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. It helps control inflammation and disease activity in these conditions.

Hydroxychloroquine accumulates in lysosomes, raising their pH and inhibiting autophagy. This disrupts antigen processing, modulates Toll‑like receptor signaling, and reduces cytokine production, thereby dampening the immune response and limiting inflammation.

The dosage of Idrossiclorochina Doc is determined by the prescribing clinician based on the specific indication, patient weight, renal function, and other clinical factors. Patients should follow the dose prescribed by their healthcare professional.

Safety in pregnancy and lactation has not been definitively established. Clinicians must weigh potential benefits against possible risks and consider alternative therapies when appropriate. Women who are pregnant, planning pregnancy, or breastfeeding should discuss options with their physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Hydroxychloroquine offers both antimalarial activity and immunomodulation, distinguishing it from agents that target only one pathway. Compared with newer biologics, it is administered orally, has a well‑characterized safety profile, and is generally less costly, though monitoring for retinal toxicity is essential.

Store Idrossiclorochina Doc at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Idrossiclorochina Doc is taken orally, usually with a full glass of water. The tablet should be swallowed whole and not chewed or crushed unless specifically instructed by a healthcare professional.

The most serious risks include retinal toxicity leading to irreversible vision loss, cardiac arrhythmias due to QT interval prolongation, and severe hypersensitivity reactions such as Stevens‑Johnson syndrome. Regular monitoring and prompt reporting of symptoms are crucial.

Patients with known hypersensitivity to hydroxychloroquine or related compounds, those with pre‑existing retinopathy, significant cardiac conduction disorders, or severe renal impairment should avoid using Idrossiclorochina Doc unless a specialist determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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