Product image of Iduren Sr (Indapamide) supplied by GNH India

Iduren Sr

Active Ingredient:
Indapamide
Origin:
EU

Iduren Sr (Indapamide)

Indapamide, the active ingredient in Iduren Sr, is a thiazide-like diuretic presented as an oral tablet for oral use. It treats hypertension and edema associated with congestive heart failure in adult patients.

GNH India supplies Iduren Sr as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Vim Spectrum Srl

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Indications & Clinical Uses

Indapamide acts on the renal distal convoluted tubule to promote diuresis and lower vascular resistance, making it useful for several cardiovascular conditions.

  • Hypertension: lowers systolic and diastolic blood pressure, reducing cardiovascular risk.
  • Edema associated with congestive heart failure: facilitates fluid removal and eases peripheral swelling.
  • Chronic heart failure: assists in managing fluid overload and improves symptom control.

How It Works

  • Indapamide inhibits the Na⁺/Cl⁻ cotransporter in the distal convoluted tubule, decreasing sodium and chloride reabsorption. This leads to increased urinary excretion of water and electrolytes, reducing plasma volume and peripheral vascular resistance, which together lower arterial blood pressure.

Side Effects

Indapamide may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Increased urinary frequency
  • Electrolyte disturbances such as low potassium
  • Mild nausea or abdominal discomfort
  • Fatigue

Serious or Rare Side Effects

  • Severe dehydration or electrolyte imbalance (e.g., hyponatremia, hypokalemia)
  • Acute allergic reactions including rash or angioedema
  • Significant hypotension leading to syncope
  • Pancreatitis
  • Severe renal impairment
  • Blood dyscrasias such as agranulocytosis

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential complications.

  • Monitor electrolytes: schedule regular blood tests for sodium and potassium levels.
  • Assess renal function: evaluate kidney status prior to and during treatment.
  • Use caution in the elderly: increased susceptibility to orthostatic hypotension.
  • Avoid concurrent NSAIDs: may blunt diuretic efficacy.
  • Store at room temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Indapamide can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Lithium: risk of lithium toxicity increases.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may reduce diuretic effect.
  • ACE inhibitors or ARBs: can cause excessive hypotension.

Moderate Interactions (Monitor Closely)

  • Digoxin: electrolyte shifts may predispose to arrhythmias.
  • Antidiabetic agents: enhanced hypoglycaemic effect possible.
  • Corticosteroids: may counteract diuretic action and affect fluid balance.

Frequently Asked Questions

Iduren Sr contains indapamide, a thiazide‑like diuretic prescribed to lower high blood pressure and to reduce fluid accumulation (edema) in patients with congestive heart failure. It is part of standard therapy for managing cardiovascular overload and preventing related complications.

Indapamide blocks the sodium‑chloride cotransporter in the distal convoluted tubule of the kidney. By inhibiting reabsorption of these ions, it promotes the excretion of water and salts, which decreases blood volume and peripheral vascular resistance, ultimately lowering arterial pressure.

The exact dose of Iduren Sr is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and renal function. Typical adult dosing ranges are established in clinical guidelines, but the prescriber will select the appropriate strength and frequency for each patient.

Safety data for indapamide during pregnancy and lactation are limited. It should only be used if the potential benefit justifies the possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives and risks with their healthcare provider.

To order Iduren Sr, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Indapamide offers a longer duration of action and a more favorable metabolic profile compared with many thiazide diuretics, showing less impact on blood glucose and lipid levels. It is often chosen when clinicians need effective blood‑pressure control with a lower risk of metabolic side effects.

Iduren Sr tablets should be stored at room temperature, below 25 °C, in their original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children. Do not store in humid or excessively hot environments.

Iduren Sr is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the specific instructions provided by their prescriber. Consistency in timing helps maintain stable blood‑pressure control.

Serious risks include severe dehydration, electrolyte imbalances such as hyponatremia or hypokalemia, marked hypotension, and rare allergic reactions. Patients should seek immediate medical attention if they experience fainting, rapid heartbeat, muscle weakness, severe dizziness, or signs of an allergic response.

Iduren Sr is contraindicated in patients with known hypersensitivity to indapamide or other sulfonamide‑derived drugs, severe renal impairment, and in those with anuria. Caution is also advised for individuals with uncontrolled electrolyte disturbances or severe liver disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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