Product image of Iganef-3 Tab (Budesonide) 3MG supplied by GNH India

Iganef-3 Tab

Active Ingredient:
Budesonide
Origin:
INDIA

Iganef-3 Tab (Budesonide) 3MG

Budesonide, the active ingredient in Iganef-3 Tab, is a glucocorticoid presented as a 3 mg tablet for oral use. It is a synthetic corticosteroid with high topical anti‑inflammatory activity and low systemic bioavailability, and it is indicated for mild to moderate Crohn's disease and mild to moderate ulcerative colitis in adult patients.

GNH India supplies Iganef-3 Tab as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing, quality assurance and regulatory support for global procurement programmes.

Strength

3MG

Pack Size

100S

Storage

Ambient

1
Pack/s
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Indications & Clinical Uses

Budesonide is a glucocorticoid used in the management of inflammatory bowel disease.

  • Crohn's disease: reduces intestinal inflammation and helps achieve remission in mild to moderate cases.
  • Ulcerative colitis: alleviates colonic inflammation and promotes clinical remission in mild to moderate disease.
  • Inflammatory bowel disease (overall): provides targeted anti‑inflammatory control for patients with limited disease extent.

How It Works

  • Budesonide binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and interacts with glucocorticoid response elements on DNA. This modulates transcription of multiple genes, suppressing pro‑inflammatory cytokines (e.g., IL‑1, IL‑6, TNF‑α) and up‑regulating anti‑inflammatory proteins, resulting in reduced leukocyte infiltration and edema in the gastrointestinal mucosa. The high first‑pass metabolism in the liver limits systemic exposure, enhancing local gastrointestinal effects while minimizing systemic side effects.

Side Effects

Budesonide may cause a range of adverse reactions, from mild and transient to potentially serious.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Headache: transient discomfort.
  • Upper respiratory tract infection: mild cold‑like symptoms.
  • Abdominal pain: crampy discomfort.

Serious or Rare Side Effects

  • Adrenal suppression: reduced endogenous cortisol production.
  • Severe infection: opportunistic bacterial or fungal infection.
  • Osteoporosis: decreased bone mineral density with prolonged use.

Precautions & Warnings

When prescribing Budesonide, consider the following precautions.

  • Pregnancy: category B; use only if the potential benefit justifies the potential risk to the fetus.
  • Infection risk: monitor patients for signs of bacterial, viral, or fungal infections.
  • Bone health: assess risk of osteoporosis during long‑term therapy.
  • Drug interactions: avoid concomitant strong CYP3A4 inhibitors that may raise systemic exposure.
  • Monitoring: periodic evaluation of cortisol levels may be required to detect adrenal insufficiency.
  • Store at ambient temperature: keep below 25 °C, retain in the original packaging and protect from moisture.

Avoid Interactions

Budesonide can interact with several medicines; awareness of the interaction level is essential.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may markedly increase systemic budesonide exposure.
  • Systemic glucocorticoids: additive immunosuppressive effects can raise infection risk.

Moderate Interactions (Monitor Closely)

  • Antifungal azoles (e.g., itraconazole): may modestly elevate budesonide plasma levels.
  • Rifampin or other CYP3A4 inducers: may reduce therapeutic efficacy.
  • Live vaccines: effectiveness may be diminished; consider timing vaccination appropriately.

Frequently Asked Questions

Iganef-3 Tab contains budesonide, a glucocorticoid indicated for the treatment of mild to moderate Crohn's disease and mild to moderate ulcerative colitis in adult patients. It works by reducing inflammation within the gastrointestinal tract, helping to achieve clinical remission and improve symptoms.

Budesonide binds to intracellular glucocorticoid receptors, forming a complex that enters the cell nucleus and modulates gene transcription. This suppresses the production of pro‑inflammatory cytokines and promotes anti‑inflammatory proteins, leading to decreased leukocyte infiltration and edema in the gut mucosa.

The dosage of Iganef-3 Tab is individualized by the prescribing clinician based on disease severity, patient weight, and response to therapy. The prescriber determines the appropriate number of tablets and dosing schedule; patients should follow the exact instructions provided on the prescription label.

Budesonide is classified as pregnancy category B, indicating that animal studies have not shown risk to the fetus and there are no adequate human studies. It may be used during pregnancy only if the potential benefit justifies any potential risk. Limited data are available for breastfeeding, and a decision should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Iganef-3 Tab. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Budesonide has high first‑pass metabolism, resulting in lower systemic exposure compared with conventional oral corticosteroids like prednisone. This profile offers effective local anti‑inflammatory action in the gut while reducing the incidence of systemic side effects such as weight gain, glucose intolerance, and adrenal suppression, making it a preferred option for targeted IBD therapy.

Iganef-3 Tab should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original blister pack or container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Iganef-3 Tab is taken orally, usually with water. It can be taken with or without food, but patients should follow the specific instructions given by their prescriber regarding timing relative to meals to maintain consistent drug absorption.

The most serious risks include adrenal suppression, which can lead to insufficient cortisol production, severe infections due to immunosuppression, and long‑term bone loss (osteoporosis). Patients should be monitored for signs of these conditions, and any concerning symptoms should be reported to a healthcare professional promptly.

Iganef-3 Tab is contraindicated in patients with known hypersensitivity to budesonide or any excipients in the tablet, and in those with systemic fungal infections. Caution is also advised for individuals with uncontrolled infections, severe liver impairment, or those receiving other potent systemic glucocorticoids.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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