Product image of Iganef-9 Tab (Budesonide) 3MG supplied by GNH India

Iganef-9 Tab

Active Ingredient:
Budesonide
Origin:
INDIA

Iganef-9 Tab (Budesonide) 3MG

Budesonide, the active ingredient in Iganef-9 Tab, is a corticosteroid presented as a 3 mg tablet for oral use. It is employed to reduce inflammation in inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, and in eosinophilic esophagitis, primarily in adult patients.

GNH India supplies Iganef-9 Tab as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Strength

3MG

Pack Size

100S

Storage

Ambient

1
Pack/s
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Indications & Clinical Uses

Budesonide is a locally acting corticosteroid that modulates inflammatory pathways in the gastrointestinal tract.

  • Crohn's disease: reduces intestinal inflammation and helps maintain remission.
  • Ulcerative colitis: decreases colonic inflammation and promotes symptom control.
  • Eosinophilic esophagitis: lessens esophageal eosinophilic inflammation and improves swallowing.

How It Works

  • Budesonide binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and regulates gene transcription. This interaction suppresses the production of pro‑inflammatory cytokines such as IL‑1, IL‑6 and TNF‑α, and inhibits leukocyte migration, leading to reduced inflammation in target tissues.

Side Effects

Budesonide may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache: mild headache reported in some patients.
  • Nausea: occasional nausea or abdominal discomfort.
  • Upper respiratory tract infection: mild infections may occur.
  • Oral thrush: candidiasis of the mouth, especially with inhaled forms but can appear.

Serious or Rare Side Effects

  • Adrenal suppression: reduced cortisol production leading to fatigue.
  • Severe hypersensitivity: rash, angioedema or anaphylaxis.
  • Osteoporosis: decreased bone mineral density with long‑term use.

Precautions & Warnings

Budesonide should be used with clinical oversight and attention to specific safety considerations.

  • Dose adjustment: required in hepatic impairment.
  • Monitor: regular assessment of disease activity and side effects.
  • Avoid abrupt discontinuation: taper to prevent adrenal insufficiency.
  • Pregnancy: category B; use only if benefit outweighs risk.
  • Drug interactions: review concomitant medications, especially CYP3A4 inhibitors.
  • Store at ambient temperature: keep below 25 °C, retain in original container, protect from moisture.

Avoid Interactions

Budesonide can interact with other medicines that affect its metabolism or amplify its pharmacologic effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic exposure.
  • Ritonavir: can markedly raise budesonide levels, increasing risk of adrenal suppression.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, phenytoin): may reduce efficacy.
  • Anticoagulants (warfarin): may enhance anticoagulant effect; monitor INR.
  • Antidiabetic drugs: glucocorticoid effect may raise blood glucose; monitor glucose levels.

Frequently Asked Questions

Iganef-9 Tab contains budesonide, a corticosteroid indicated for the treatment of inflammatory bowel conditions such as Crohn's disease and ulcerative colitis, as well as eosinophilic esophagitis. It works by reducing inflammation in the gastrointestinal tract, helping to control symptoms and maintain remission in these disorders.

Budesonide binds to glucocorticoid receptors inside cells, forming a complex that moves into the nucleus and alters gene expression. This process suppresses the production of pro‑inflammatory cytokines and inhibits immune cell migration, resulting in decreased inflammation in the affected tissues.

The appropriate dose of Iganef-9 Tab is determined by the prescribing clinician based on the specific indication, disease severity, and patient characteristics. Dosage regimens are individualized and should follow the prescriber’s instructions without deviation.

Budesonide is classified as pregnancy category B, indicating that animal studies have not shown risk to the fetus and there are no adequate human studies. It may be used during pregnancy only if the potential benefit justifies any potential risk. Limited data are available for breastfeeding, so a risk‑benefit assessment is required.

To order Iganef-9 Tab, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with systemic corticosteroids, budesonide has high first‑pass metabolism, resulting in lower systemic exposure and fewer classic steroid side effects. It provides potent local anti‑inflammatory activity in the gut, making it a preferred option for targeted treatment of inflammatory bowel disease when oral delivery is appropriate.

Iganef-9 Tab should be stored at ambient temperature, below 25 °C. Keep the tablets in the original packaging to protect them from moisture and light. Do not store in a refrigerator or freezer, and keep out of reach of children.

Iganef-9 Tab is taken orally. Swallow the tablet whole with a glass of water, preferably with food to reduce gastrointestinal irritation. Follow the dosing schedule prescribed by the healthcare professional and do not crush or chew the tablet unless instructed otherwise.

The most serious risks include adrenal suppression, which can lead to fatigue and hypotension, severe hypersensitivity reactions such as rash or anaphylaxis, and long‑term bone loss resulting in osteoporosis. Patients should be monitored regularly for these potential complications.

Iganef-9 Tab is contraindicated in individuals with known hypersensitivity to budesonide or any excipients, and in patients with systemic fungal infections. Caution is also advised for those with uncontrolled infections, severe liver disease, or conditions that may be exacerbated by glucocorticoids.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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