Product image of Igantibe (Human Hepatitis B Immunoglobulin) supplied by GNH India

Igantibe

Active Ingredient:
Human Hepatitis B Immunoglobulin
Origin:
EU

Igantibe (Human Hepatitis B Immunoglobulin)

Human Hepatitis B Immunoglobulin, the active ingredient in Igantibe, is an immunoglobulin presented as a solution for injection for intramuscular use. It provides passive immunity to prevent hepatitis B infection in individuals at risk, such as after exposure or following liver transplantation.

GNH India supplies Igantibe as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and pharmacies worldwide.

Manufacturer / TM Owner

Instituto Grifols, S.A.

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Indications & Clinical Uses

Igantibe is a hepatitis B immune globulin used to prevent infection by supplying anti‑HBs antibodies.

  • Post‑exposure prophylaxis of hepatitis B: reduces the risk of infection after accidental or occupational exposure to hepatitis B virus.
  • Prevention of hepatitis B recurrence after liver transplantation: helps maintain viral suppression in transplant recipients.
  • Prevention of hepatitis B infection in newborns of HBV‑positive mothers: provides passive immunity to infants at birth.

How It Works

  • Human Hepatitis B Immunoglobulin supplies exogenous anti‑HBs antibodies that bind to hepatitis B virus particles, neutralizing them and preventing attachment to hepatocytes. This passive immunity blocks viral entry and replication, offering immediate protection while the host’s own immune response develops.

Side Effects

Igantibe may cause a range of adverse reactions following intramuscular administration.

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the injection site.
  • Redness or swelling: localized erythema or edema.
  • Fever: transient low‑grade temperature elevation.
  • Headache: mild to moderate headache after dosing.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Serum sickness‑like reaction: fever, rash, arthralgia occurring days after administration.
  • Severe hypersensitivity: urticaria, angioedema, or bronchospasm.

Precautions & Warnings

Before using Igantibe, consider the following safety measures.

  • Assess HBV serostatus: confirm patient’s hepatitis B infection or exposure status.
  • Check for hypersensitivity: avoid in individuals with known allergy to human immunoglobulins.
  • Avoid in severe IgA deficiency: risk of anaphylactic reactions.
  • Monitor for infection signs: observe for fever, rash, or respiratory symptoms after injection.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Igantibe can interact with other agents that affect immune response or vaccine efficacy.

Major Interactions (Avoid)

  • Live attenuated vaccines: may reduce vaccine effectiveness; avoid concurrent administration.
  • Immunosuppressive therapy: may diminish passive immunity benefits.

Moderate Interactions (Monitor Closely)

  • Blood products containing anti‑HBs: potential additive antibody effect.
  • Antiviral agents for hepatitis B: monitor for overlapping immunologic effects.
  • Other immunoglobulin preparations: assess cumulative antibody load.

Frequently Asked Questions

Igantibe is a hepatitis B immune globulin indicated for post‑exposure prophylaxis of hepatitis B infection and for preventing hepatitis B recurrence after liver transplantation. It supplies anti‑HBs antibodies to provide immediate passive immunity.

The immunoglobulin contains anti‑HBs antibodies that bind to hepatitis B virus particles, neutralizing them and blocking entry into liver cells. This passive immunity offers rapid protection while the patient’s own immune system develops a response.

The dose of Igantibe is determined by the prescribing clinician based on the patient’s weight, exposure risk, and clinical situation. Specific dosing regimens are individualized and should follow local medical guidelines.

The safety of Igantibe in pregnancy and lactation has not been fully established. Clinicians should weigh potential benefits against unknown risks and consider alternative options when appropriate.

To order Igantibe, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and necessary import documentation.

Igantibe contains the same human anti‑HBs antibodies as other hepatitis B immune globulins, but its formulation as a sterile solution for intramuscular injection meets EU quality standards. Clinical efficacy and safety are comparable when used according to prescribing information.

Igantibe must be stored refrigerated at 2‑8 °C, protected from light, and should never be frozen or shaken. Keep the vial in its original packaging until use to maintain stability.

Igantibe is given as an intramuscular injection into a suitable muscle, typically the deltoid or gluteal region. Administration should be performed by qualified healthcare personnel following aseptic technique.

Serious risks include anaphylactic reactions, serum‑sickness‑like responses, and severe hypersensitivity. Immediate medical attention is required if symptoms such as difficulty breathing, swelling, or widespread rash occur after injection.

Igantibe should not be used in individuals with known hypersensitivity to human immunoglobulins or in patients with severe IgA deficiency due to the risk of anaphylaxis. Contraindications must be assessed by the prescribing clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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