Product image of Igroseles (Atenolol, Chlortalidone) supplied by GNH India

Igroseles

Active Ingredient:
Atenolol, Chlortalidone
Origin:
EU

Igroseles (Atenolol, Chlortalidone)

Atenolol and chlortalidone, the active ingredients in Igroseles, are a beta‑blocker and a thiazide‑like diuretic presented as an oral tablet for oral use. They are prescribed to manage hypertension in adult patients, helping to lower both systolic and diastolic blood pressure. Igroseles is marketed in the European Union and complies with EU pharmaceutical standards.

GNH India supplies Igroseles as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teofarma S.R.L.

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Indications & Clinical Uses

Igroseles, a combination antihypertensive, is used to treat conditions related to elevated blood pressure.

  • Essential hypertension: lowers systolic and diastolic pressure to target levels.
  • Isolated systolic hypertension: provides effective control, especially in older adults.
  • Hypertensive patients with fluid retention: combines beta‑blockade and diuresis to improve overall blood pressure management.

How It Works

  • Atenolol selectively blocks β1‑adrenergic receptors, reducing heart rate, myocardial contractility, and renin release. Chlortalidone inhibits NaCl reabsorption in the distal convoluted tubule, increasing natriuresis and decreasing plasma volume. The combined actions result in reduced cardiac output and peripheral resistance, leading to lower arterial blood pressure.

Side Effects

Common Side Effects

  • Dizziness: mild to moderate light‑headedness, especially after standing.
  • Fatigue: general tiredness or reduced energy levels.
  • Cold extremities: reduced blood flow to hands and feet.
  • Increased urination: due to diuretic effect of chlortalidone.
  • Electrolyte imbalance: mild changes in potassium or sodium levels.
  • Gastrointestinal discomfort: occasional nausea or abdominal pain.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure causing fainting.
  • Significant electrolyte disturbances: pronounced hypokalemia or hyponatremia.
  • Renal impairment: worsening kidney function in susceptible individuals.
  • Allergic reactions: rash, itching, or swelling of face and throat.
  • Bradycardia: abnormally slow heart rate.
  • Pancreatitis: rare inflammation of the pancreas.

Precautions & Warnings

Patients should be monitored regularly while using Igroseles.

  • Monitor blood pressure: ensure readings stay within therapeutic targets.
  • Assess renal function: check creatinine and eGFR before and during therapy.
  • Check electrolyte levels: especially potassium and sodium, due to diuretic effect.
  • Use caution in asthma: β1‑selectivity may still affect bronchial tone.
  • Avoid abrupt discontinuation: taper dose to prevent rebound hypertension.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Igroseles may interact with several other medicines.

Major Interactions (Avoid)

  • Non‑selective β‑blockers: additive bradycardia and hypotension.
  • Potassium‑sparing diuretics or supplements: risk of hyperkalemia.
  • NSAIDs: may reduce antihypertensive efficacy and affect renal function.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: enhanced hypotensive effect.
  • Antidiabetic agents: possible masking of hypoglycemia symptoms.
  • Calcium channel blockers: may increase risk of bradycardia.
  • Antidepressants (e.g., SSRIs): potential for increased blood pressure variability.

Frequently Asked Questions

Igroseles is a prescription medication that combines atenolol and chlortalidone to treat hypertension. It helps lower high blood pressure by reducing heart rate and decreasing fluid volume, providing a dual mechanism for effective blood pressure control in adults.

Atenolol is a selective β1‑adrenergic receptor antagonist. By blocking these receptors, it slows the heart rate, reduces the force of cardiac contraction, and lowers renin release from the kidneys, which together contribute to a reduction in blood pressure.

The dosage of Igroseles is determined by the prescribing clinician based on the patient’s individual health status, blood pressure goals, and response to therapy. The prescriber will select the appropriate strength and dosing schedule.

The safety of Igroseles in pregnancy and lactation has not been fully established. Healthcare providers should weigh potential benefits against possible risks and consider alternative treatments when treating pregnant or nursing individuals.

To order Igroseles, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Igroseles offers a combined β1‑blocker and thiazide‑like diuretic in a single tablet, which can simplify regimens compared with taking separate agents. This dual action may provide more consistent blood pressure control than monotherapy, though individual response varies and should be assessed by a clinician.

Igroseles should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the tablets away from moisture, heat, and direct sunlight to maintain product stability throughout its shelf life.

Igroseles is taken orally, usually once daily with or without food, as directed by a healthcare professional. Swallow the tablet whole with a full glass of water and follow the prescriber’s instructions regarding timing and any dose adjustments.

Serious risks include severe hypotension, significant electrolyte disturbances such as hypokalemia, renal impairment, and rare allergic reactions. Patients should be monitored for symptoms like fainting, muscle weakness, rapid weight change, or swelling, and report any concerns promptly.

Igroseles is contraindicated in patients with known hypersensitivity to atenolol, chlortalidone, or any excipients, as well as those with severe bradycardia, second‑ or third‑degree heart block, or uncontrolled heart failure. Individuals with severe renal impairment should also avoid this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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