Product image of Ikobel (Tobramycin) supplied by GNH India

Ikobel

Active Ingredient:
Tobramycin
Origin:
EU

Ikobel (Tobramycin)

Tobramycin, the active ingredient in Ikobel, is an aminoglycoside antibiotic presented as an ophthalmic solution for ocular use. It treats bacterial infections of the eye such as conjunctivitis and keratitis in patients requiring prescription therapy. The formulation is designed for topical application to the conjunctival sac, delivering high local concentrations while minimizing systemic exposure.

GNH India supplies Ikobel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Rafarm Sa.

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Indications & Clinical Uses

Tobramycin is an aminoglycoside antibiotic used to treat bacterial infections of the eye.

  • Bacterial conjunctivitis: reduces bacterial load and alleviates inflammation in the conjunctiva.
  • Keratitis: eradicates pathogenic bacteria causing corneal infection and promotes healing.
  • Post‑operative ocular infection: helps prevent or treat bacterial contamination after eye surgery.
  • Other ocular bacterial infections: provides broad‑spectrum coverage for various bacterial eye conditions.

How It Works

  • Tobramycin binds to the 30S subunit of bacterial ribosomes, causing misreading of mRNA and inhibition of protein synthesis. This disruption leads to rapid bactericidal activity against susceptible Gram‑negative and some Gram‑positive ocular pathogens, limiting infection progression.

Side Effects

Adverse reactions may occur following ocular administration of Tobramycin.

Common Side Effects

  • Eye irritation or burning sensation.
  • Redness of the conjunctiva.
  • Excessive tearing or discharge.
  • Blurred vision.
  • Foreign body sensation.
  • Mild eyelid edema.

Serious or Rare Side Effects

  • Allergic reaction (e.g., swelling, rash, anaphylaxis).
  • Corneal ulceration or severe keratitis.
  • Significant eye pain or vision loss.
  • Systemic absorption leading to nephrotoxicity.
  • Ototoxicity (rare with ocular use).
  • Persistent intraocular inflammation.

Precautions & Warnings

Before using Ikobel, consider the following safety measures.

  • Assess for hypersensitivity: discontinue if signs of allergic reaction appear.
  • Evaluate renal function: use caution in patients with impaired kidney function.
  • Monitor for ototoxicity: be alert for hearing changes, especially with prolonged use.
  • Avoid concurrent use with other aminoglycoside eye drops unless directed.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Tobramycin may interact with other medications administered to the eye or systemically.

Major Interactions (Avoid)

  • Other aminoglycoside ophthalmic preparations: increased risk of toxicity.
  • Loop diuretics (e.g., furosemide): may potentiate nephrotoxic effects if systemic absorption occurs.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may mask signs of infection.
  • Other ophthalmic antibiotics: assess for additive toxicity.
  • Systemic nephrotoxic agents (e.g., vancomycin, amphotericin B): monitor renal function.

Frequently Asked Questions

Ikobel contains Tobramycin and is indicated for the treatment of bacterial infections of the eye, including bacterial conjunctivitis, keratitis, and other ocular bacterial conditions that require prescription‑only therapy.

Tobramycin binds to the 30S ribosomal subunit of susceptible bacteria, causing misreading of messenger RNA and halting protein synthesis. This results in rapid bactericidal activity against the organisms causing the eye infection.

The dosing regimen for Ikobel is determined by the prescribing clinician based on the severity of the infection, patient age, and response to therapy. Typical regimens involve one or more drops applied to the affected eye(s) at prescribed intervals.

The pregnancy category for Tobramycin ophthalmic preparations is listed as unknown. Because systemic absorption is possible, it should be used during pregnancy or lactation only if the potential benefit justifies the potential risk, and under medical supervision.

To order Ikobel, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Ikobel (Tobramycin) belongs to the aminoglycoside class and offers strong activity against many Gram‑negative ocular pathogens. Compared with fluoroquinolone eye drops, it may have a narrower spectrum but is effective for resistant strains. Choice of therapy depends on bacterial susceptibility, patient tolerance, and clinician preference.

Ikobel should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and discard any solution that appears discolored or cloudy.

Ikobel is applied topically to the eye. The patient should wash hands, tilt the head back, pull down the lower eyelid, place the prescribed number of drops into the conjunctival sac, and close the eye gently. Avoid touching the dropper tip to any surface.

Serious risks include allergic reactions such as swelling, rash, or anaphylaxis; corneal ulceration or severe keratitis; significant eye pain or vision loss; and, rarely, systemic toxicity leading to kidney or ear damage if absorption occurs.

Ikobel should not be used by individuals with a known hypersensitivity to Tobramycin or any other aminoglycoside. Caution is advised in patients with severe renal impairment, and it should be avoided in eyes with a perforated cornea unless directed by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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