Product image of Ikorel (Nicorandil) supplied by GNH India

Ikorel

Active Ingredient:
Nicorandil
Origin:
EU

Ikorel (Nicorandil)

Nicorandil, the active ingredient in Ikorel, is a potassium channel activator presented as an oral dosage form for oral use. It is used to treat stable angina pectoris in adult patients.
GNH India supplies Ikorel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi Winthrop Industrie

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Indications & Clinical Uses

Ikorel, a potassium channel activator, is indicated for conditions involving myocardial oxygen demand and supply mismatch.

  • Stable angina pectoris: improves exercise tolerance and reduces frequency of angina attacks.

How It Works

  • Nicorandil donates nitric oxide, stimulating guanylate cyclase and increasing cyclic GMP, while simultaneously opening ATP‑sensitive potassium channels in vascular smooth muscle. The combined vasodilatory actions lower preload and afterload, enhancing coronary blood flow and reducing myocardial oxygen consumption.

Side Effects

Nicorandil may cause a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate pressure sensation.
  • Flushing: transient warmth and redness of skin.
  • Dizziness: sensation of light‑headedness, especially on standing.
  • Nausea: mild stomach upset.
  • Palpitations: awareness of heartbeats.
  • Hypotension: low blood pressure, often orthostatic.

Serious or Rare Side Effects

  • Gastro‑intestinal ulceration: painful sores in mouth, esophagus or stomach.
  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Stevens‑Johnson syndrome: rare severe skin reaction.
  • Myocardial infarction: rare worsening of heart ischemia.
  • Anaphylaxis: acute allergic reaction.
  • Hepatic dysfunction: abnormal liver enzyme elevations.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Blood pressure monitoring: check baseline and periodic readings.
  • Ulcer assessment: evaluate for existing gastrointestinal lesions.
  • Hepatic function: assess liver enzymes in patients with liver disease.
  • Concomitant vasodilators: use caution with other blood‑pressure‑lowering agents.
  • Severe hypotension: avoid in patients with markedly low blood pressure.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Nicorandil can interact with several drug classes, requiring attention to dosing and monitoring.

Major Interactions (Avoid)

  • Nitrates: additive vasodilation may cause severe hypotension.
  • Phosphodiesterase‑5 inhibitors: risk of profound blood pressure fall.
  • Other potassium channel openers: increased risk of hypotension.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (e.g., ACE inhibitors, beta‑blockers): may enhance blood pressure lowering.
  • Diuretics: potential for electrolyte imbalance and hypotension.
  • Alcohol: can potentiate vasodilatory effects.

Frequently Asked Questions

Ikorel contains nicorandil, which is prescribed to relieve symptoms of stable angina pectoris. It helps reduce the frequency of chest pain episodes by improving blood flow to the heart muscle.

Nicorandil works by releasing nitric oxide, which relaxes blood vessels, and by opening ATP‑sensitive potassium channels in vascular smooth muscle. This dual action dilates coronary and peripheral arteries, lowering cardiac workload.

The dosage of Ikorel is determined by the prescribing clinician based on the patient’s condition, response, and tolerance. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for nicorandil in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

To request Ikorel, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike pure nitrates, nicorandil combines nitric‑oxide donation with potassium‑channel activation, offering both arterial and venous dilation. This dual mechanism can provide better symptom control for some patients, but choice of therapy depends on individual clinical factors.

Store Ikorel at temperatures below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed.

Ikorel is taken orally, usually with or without food as directed by the prescriber. Swallow the tablet whole with a glass of water and do not crush or chew it unless instructed otherwise.

Serious risks include severe hypotension, gastrointestinal ulceration (especially in the mouth, esophagus or stomach), and rare severe skin reactions such as Stevens‑Johnson syndrome. Patients should report any unusual pain, bleeding, or skin changes promptly.

Ikorel should be avoided in patients with known hypersensitivity to nicorandil, active gastrointestinal ulcer disease, severe hypotension, or those taking contraindicated vasodilators such as other nitrates without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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