Product image of Ikynol (Allopurinol) supplied by GNH India

Ikynol

Active Ingredient:
Allopurinol
Origin:
EU

Ikynol (Allopurinol)

Allopurinol, the active ingredient in Ikynol, is a xanthine oxidase inhibitor presented as an oral tablet for oral use. It lowers uric acid production and is used to manage gout, hyperuricemia, and to prevent tumor lysis syndrome in patients undergoing chemotherapy.

GNH India supplies Ikynol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Allopurinol is approved in the European Union for these indications and is manufactured under strict GMP conditions.

Manufacturer / TM Owner

Laboratórios Basi – Indústria Farmacêutica, S.A.

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Indications & Clinical Uses

Allopurinol is a xanthine oxidase inhibitor used to manage conditions related to excess uric acid.

  • Gout: Reduces serum uric acid levels to prevent acute attacks and chronic joint damage.
  • Hyperuricemia: Lowers uric acid concentration in patients with elevated levels not due to gout.
  • Tumor lysis syndrome: Prevents rapid uric acid accumulation during chemotherapy for high‑risk malignancies.
  • Uric acid nephrolithiasis: Decreases risk of kidney stone formation by lowering uric acid.

How It Works

  • Allopurinol competitively inhibits the enzyme xanthine oxidase, which is responsible for converting hypoxanthine to xanthine and xanthine to uric acid. By blocking this pathway, the drug reduces the synthesis of uric acid, leading to lower serum uric acid concentrations and diminished crystal formation in joints and kidneys.

Side Effects

Allopurinol may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Rash or mild skin irritation.
  • Nausea, vomiting or abdominal discomfort.
  • Diarrhea or loose stools.
  • Elevated liver enzymes detected on routine labs.
  • Itching (pruritus) without rash.
  • Altered taste sensation.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Severe hypersensitivity syndrome with fever and organ involvement.
  • Bone marrow suppression leading to anemia or leukopenia.
  • Acute hepatic failure.
  • Acute renal impairment or interstitial nephritis.
  • Life‑threatening anaphylactic reactions.

Precautions & Warnings

When prescribing Allopurinol, clinicians should consider several safety factors.

  • Renal function: Adjust dose in patients with impaired renal clearance.
  • Hepatic function: Monitor liver enzymes during therapy.
  • Allergy history: Avoid if known hypersensitivity to allopurinol or its metabolites.
  • Drug interactions: Review concomitant medications for potential interactions.
  • Pregnancy and lactation: Use only if benefits outweigh potential risks.
  • Store at ambient temperature: Keep below 25°C in the original packaging, protect from moisture.

Avoid Interactions

Allopurinol interacts with several medicines; careful review is essential.

Major Interactions (Avoid)

  • Azathioprine or mercaptopurine: May cause severe bone marrow suppression.
  • Amoxicillin‑clavulanate: Increases risk of serious skin reactions such as SJS.
  • Warfarin: Allopurinol can potentiate anticoagulant effect, raising INR.
  • Cyclosporine: May increase allopurinol plasma levels, risking toxicity.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: Can reduce uric acid‑lowering efficacy.
  • ACE inhibitors or ARBs: May modestly increase serum potassium.
  • NSAIDs: May affect renal function when combined with allopurinol.
  • Theophylline: Allopurinol can decrease its clearance, requiring dose adjustment.

Frequently Asked Questions

Ikynol contains allopurinol, which is prescribed to lower uric acid levels. It is used to treat gout, manage chronic hyperuricemia, and to prevent tumor lysis syndrome in patients receiving chemotherapy for high‑risk cancers.

Allopurinol blocks the enzyme xanthine oxidase, preventing the conversion of hypoxanthine and xanthine into uric acid. This reduction in uric acid synthesis lowers its concentration in the blood, decreasing crystal formation in joints and kidneys.

The appropriate dose of Ikynol is individualized by the prescribing clinician based on the patient’s condition, renal function, and response to therapy. Dosage adjustments are made according to clinical guidelines and laboratory monitoring.

Safety data for allopurinol in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Ikynol, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative to allopurinol is febuxostat, another xanthine oxidase inhibitor. Febuxostat may be preferred in patients who cannot tolerate allopurinol, but allopurinol remains the first‑line therapy in most guidelines due to its long‑standing safety record and lower cost.

Ikynol tablets should be stored at ambient temperature, preferably below 25 °C, in their original container to protect from moisture and light. Keep out of reach of children and do not use after the expiry date printed on the packaging.

Ikynol is taken orally, usually with a full glass of water. It can be taken with or without food, but consistent timing with meals may help reduce gastrointestinal discomfort. Follow the prescribing clinician’s instructions for frequency and duration.

Serious adverse reactions include severe hypersensitivity syndromes such as Stevens‑Johnson syndrome, toxic epidermal necrolysis, and drug‑induced hypersensitivity syndrome. Life‑threatening organ involvement, bone marrow suppression, and acute hepatic or renal failure are also rare but critical risks that require immediate medical attention.

Ikynol should be avoided in individuals with known hypersensitivity to allopurinol or oxypurinol, and in patients with severe renal impairment where dose adjustment is not feasible. Caution is also advised for those with a history of severe skin reactions to related medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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