Product image of Ilaris 150 (Canakinumab ) 150mg/ml x 6ml Vials supplied by GNH India

Ilaris 150

Active Ingredient:
Canakinumab
Form:
Vials
Brand:
Ilaris 150mg-TU
Origin:
Switzerland

Ilaris 150 (Canakinumab Vials) 150mg/ml x 6ml

Canakinumab, the active ingredient in Ilaris 150, is a monoclonal antibody presented as a 150mg/ml vial for injectable use. It is used to treat various auto-inflammatory and autoimmune conditions in adults and children aged 2 years and older.

GNH India supplies Ilaris 150 as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

Strength

150mg/ml x 6ml

Manufacturer / TM Owner

Novartis Pharma S.A.S.

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Indications & Clinical Uses

Ilaris 150 is used to treat a range of auto-inflammatory and autoimmune conditions by inhibiting the activity of interleukin-1 beta (IL-1β).

  • Cryopyrin-associated periodic syndromes (CAPS): Reduces inflammation and symptoms associated with these syndromes.
  • Systemic juvenile idiopathic arthritis (SJIA): Helps manage symptoms in children who do not respond adequately to other treatments.
  • Familial Mediterranean fever (FMF): Alleviates symptoms and reduces the frequency of attacks.
  • Gout flares: Provides relief during acute gout attacks.
  • Hyperphosphatasia with mental retardation syndrome: Manages symptoms and reduces inflammation.

How It Works

  • Canakinumab is a selective human monoclonal antibody that binds to interleukin-1 beta (IL-1β), neutralizing its activity. By inhibiting IL-1β, it reduces inflammation and the associated symptoms in various auto-inflammatory and autoimmune conditions.

Side Effects

Ilaris 150 may cause several side effects, ranging from common to serious or rare.

Common Side Effects

  • Injection site reactions: Redness, swelling, or pain at the injection site.
  • Upper respiratory infections: Symptoms such as cough, runny nose, or sore throat.
  • Headache: Mild to moderate headaches.
  • Diarrhea: Loose stools or frequent bowel movements.
  • Nausea: Feeling sick to the stomach.
  • Fatigue: Feeling tired or weak.
  • Increased risk of infections: Due to the suppression of the immune system.

Serious or Rare Side Effects

  • Serious infections: Including tuberculosis and opportunistic infections.
  • Allergic reactions: Severe allergic reactions, including anaphylaxis.
  • Macrophage activation syndrome (MAS): A serious complication of autoimmune diseases.
  • Neutropenia: Low levels of neutrophils, a type of white blood cell.

Precautions & Warnings

Ilaris 150 should be used with caution and under medical supervision. Important precautions include:

  • Infections: Patients should be monitored for signs of infection before and during treatment.
  • Vaccinations: Live vaccines should be avoided during treatment with Ilaris 150.
  • Allergic reactions: Patients with a history of allergic reactions should be closely monitored.
  • Pregnancy: The safety of Ilaris 150 during pregnancy has not been established; consult a healthcare provider.
  • Breastfeeding: The safety of Ilaris 150 during breastfeeding has not been established; consult a healthcare provider.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ilaris 150 may interact with other medications, requiring careful monitoring or avoidance.

Major Interactions (Avoid)

  • Live vaccines: Avoid concurrent use due to the risk of infection.
  • Other biologics: Avoid concurrent use with other biologics to prevent increased risk of infections.
  • Immunosuppressants: Avoid concurrent use to prevent excessive immunosuppression.

Moderate Interactions (Monitor Closely)

  • Corticosteroids: Monitor for increased risk of infections and other side effects.
  • Methotrexate: Monitor for increased risk of infections and other side effects.
  • Non-steroidal anti-inflammatory drugs (NSAIDs): Monitor for increased risk of gastrointestinal side effects.

Frequently Asked Questions

Ilaris 150 is used to treat various auto-inflammatory and autoimmune conditions, including cryopyrin-associated periodic syndromes (CAPS), systemic juvenile idiopathic arthritis (SJIA), familial Mediterranean fever (FMF), gout flares, and hyperphosphatasia with mental retardation syndrome. It works by inhibiting the activity of interleukin-1 beta (IL-1β), reducing inflammation and associated symptoms.

Canakinumab is a selective human monoclonal antibody that binds to interleukin-1 beta (IL-1β), neutralizing its activity. By inhibiting IL-1β, it reduces inflammation and the associated symptoms in various auto-inflammatory and autoimmune conditions. This mechanism helps manage symptoms and improve the quality of life for patients with these conditions.

The usual dose of Ilaris 150 is determined by a healthcare provider based on the patient's condition, age, and weight. It is typically administered as an injection, and the dosage and frequency are tailored to the specific needs of the patient. Always follow the prescribing healthcare provider's instructions for the correct dosage and administration.

The safety of Ilaris 150 during pregnancy and breastfeeding has not been established. Patients who are pregnant, planning to become pregnant, or breastfeeding should consult their healthcare provider before using Ilaris 150. The healthcare provider can provide guidance based on the patient's specific situation and medical history.

To order Ilaris 150 from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask the buyer to confirm their trade or institutional credentials and will reply with pricing, availability, shipping (including cold-chain where relevant), and the import paperwork.

Ilaris 150 is a monoclonal antibody that specifically targets interleukin-1 beta (IL-1β), making it effective for conditions driven by excessive IL-1β activity. Compared to other treatments, such as corticosteroids or non-steroidal anti-inflammatory drugs (NSAIDs), Ilaris 150 offers a more targeted approach with potentially fewer systemic side effects. However, the choice of treatment depends on the patient's specific condition and response to therapy.

Ilaris 150 should be stored at 2-8°C, kept refrigerated, and protected from light. It should not be frozen or shaken. The medication should be kept in its original packaging until use. Always follow the storage instructions provided by the manufacturer to ensure the stability and effectiveness of the medication.

Ilaris 150 is administered as an injection, typically by a healthcare provider. The injection is usually given subcutaneously (under the skin) or intravenously (into a vein), depending on the specific instructions provided by the healthcare provider. Patients should follow the administration instructions carefully to ensure proper use of the medication.

The most serious risks associated with Ilaris 150 include serious infections, such as tuberculosis and opportunistic infections, allergic reactions, including anaphylaxis, and macrophage activation syndrome (MAS). Patients should be monitored closely for signs of these complications, and any concerning symptoms should be reported to a healthcare provider immediately.

Ilaris 150 should not be used by patients with a known hypersensitivity to canakinumab or any of the excipients in the formulation. Patients with active infections or those who have recently received live vaccines should also avoid using Ilaris 150. Always consult a healthcare provider to determine if Ilaris 150 is appropriate for your specific medical situation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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