Product image of Ilgem (Ketoconazole) supplied by GNH India

Ilgem

Active Ingredient:
Ketoconazole
Origin:
EU

Ilgem (Ketoconazole)

Ketoconazole, the active ingredient in Ilgem, is a azole antifungal presented as a topical formulation for skin use. It treats fungal skin infections such as tinea and seborrheic dermatitis in patients requiring topical therapy.

GNH India supplies Ilgem as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Rafarm Sa.

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Indications & Clinical Uses

  • Ketoconazole acts on dermatophyte and yeast infections of the skin and scalp.
  • Tinea corporis: reduces fungal growth and clears body ringworm lesions.
  • Tinea cruris: alleviates itching and clears groin fungal infection.
  • Tinea pedis: treats athlete's foot by eliminating dermatophytes.
  • Seborrheic dermatitis: controls Malassezia overgrowth and improves scalp scaling.
  • Cutaneous candidiasis: eradicates Candida species from affected skin areas.

How It Works

  • Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking ergosterol production, the drug disrupts fungal cell membrane integrity, leading to impaired growth and eventual cell death of susceptible dermatophytes and yeasts.

Side Effects

Ketoconazole may cause local skin reactions when applied topically.

Common Side Effects

  • Burning sensation at the application site.
  • Itching or pruritus.
  • Redness or erythema.
  • Dryness or flaking of the skin.
  • Stinging or mild pain.
  • Contact dermatitis.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis).
  • Extensive skin blistering or Stevens‑Johnson syndrome.
  • Widespread dermatitis.
  • Systemic absorption leading to liver enzyme abnormalities (rare).
  • Phototoxic reactions.
  • Persistent ulceration of the treated area.

Precautions & Warnings

  • When using topical ketoconazole, consider the following safety measures.
  • Avoid use on broken or inflamed skin: may increase systemic absorption.
  • Do not apply near eyes or mucous membranes: can cause irritation.
  • Limit duration to the prescribed period: prolonged use may increase irritation risk.
  • Discontinue if severe redness, swelling, or pain develops: seek medical advice.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Ketoconazole can interact with other medicines, especially when systemic absorption occurs.

Major Interactions (Avoid)

  • Concurrent use of systemic azole antifungals: may increase overall azole exposure.
  • Warfarin: potential enhancement of anticoagulant effect.
  • CYP3A4 substrate drugs: risk of elevated plasma levels.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may mask irritation signs.
  • Hair dyes containing para‑phenylenediamine: increased risk of contact dermatitis.
  • Other topical antifungals: additive irritation potential.

Frequently Asked Questions

Ilgem contains ketoconazole and is used to treat superficial fungal skin infections such as tinea corporis, tinea cruris, tinea pedis, seborrheic dermatitis, and cutaneous candidiasis.

Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, blocking ergosterol synthesis. This disrupts the fungal cell membrane, halting growth and leading to cell death of dermatophytes and yeasts.

The dosage and frequency of Ilgem are determined by the prescribing healthcare professional based on the specific infection, severity, and patient factors. Patients should follow the prescriber’s instructions.

Safety of topical ketoconazole in pregnancy or lactation has not been fully established. Healthcare providers should weigh potential benefits against risks and consider alternative treatments when appropriate.

Enquiries can be submitted on the Ilgem product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Ilgem (ketoconazole) belongs to the azole class, offering broad‑spectrum activity against dermatophytes and yeasts. Compared with allylamine agents like terbinafine, ketoconazole has a slightly different spectrum and may be preferred for seborrheic dermatitis where Malassezia species predominate.

Store Ilgem at room temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed.

Ilgem is applied topically to the affected skin area, usually once or twice daily as directed by the prescriber. The skin should be clean and dry before applying a thin layer and gently massaging it in.

Serious risks include severe allergic reactions such as anaphylaxis, extensive skin blistering or Stevens‑Johnson syndrome, and rare systemic effects like liver enzyme abnormalities if significant absorption occurs.

Ilgem should not be used on patients with known hypersensitivity to ketoconazole or any azole antifungal, on broken or severely inflamed skin, and it is contraindicated in individuals who have experienced severe cutaneous reactions to similar products.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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