Product image of Ilomedin 20 (Iloprost Trometamol) supplied by GNH India

Ilomedin 20

Active Ingredient:
Iloprost Trometamol
Origin:
EU

Ilomedin 20 (Iloprost Trometamol)

Iloprost trometamol, the active ingredient in Ilomedin 20, is a prostacyclin analog presented as a 20 µg/mL intravenous solution for intravenous use. It treats pulmonary arterial hypertension, digital ulcers associated with systemic sclerosis, and peripheral arterial disease in appropriate patients.

GNH India supplies Ilomedin 20 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, specialty clinics, transplant centres and pharmacies worldwide, with a focus on quality and regulatory compliance.

Manufacturer / TM Owner

Bayer Ag

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Indications & Clinical Uses

Iloprost trometamol is employed in disorders characterized by elevated pulmonary vascular resistance and peripheral vasculopathy.

  • Pulmonary arterial hypertension: improves exercise capacity and lowers pulmonary arterial pressure.
  • Digital ulcers associated with systemic sclerosis: promotes ulcer healing and reduces formation of new lesions.
  • Peripheral arterial disease: enhances limb perfusion and may alleviate claudication symptoms.

How It Works

  • Iloprost trometamol selectively activates the IP (prostacyclin) receptor on vascular smooth‑muscle cells, triggering cyclic AMP accumulation that leads to potent vasodilation, inhibition of platelet aggregation, and anti‑proliferative effects on the vascular wall, thereby improving blood flow in affected vascular beds.

Side Effects

Ilomedin 20 may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of the skin.
  • Nausea: occasional gastrointestinal upset.
  • Diarrhea: loose stools.

Serious or Rare Side Effects

  • Hypotension: significant drop in blood pressure requiring medical attention.
  • Pulmonary edema: accumulation of fluid in the lungs.
  • Bleeding complications: increased risk of hemorrhage due to platelet inhibition.

Precautions & Warnings

When using Ilomedin 20, clinicians should observe specific safety measures.

  • Cardiovascular monitoring: observe blood pressure and heart rate during infusion.
  • Renal impairment: adjust therapy and monitor renal function.
  • Hepatic dysfunction: use cautiously in patients with liver disease.
  • Pregnancy: avoid use unless benefits outweigh risks; safety not established.
  • Concomitant vasodilators: assess for additive hypotensive effect.
  • Store at ambient temperature: keep below 25 °C, protect from light and moisture, retain in original container.

Avoid Interactions

Ilomedin 20 can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Phosphodiesterase‑5 inhibitors: may cause severe hypotension.
  • Nitrates: additive vasodilatory effect leading to dangerous blood pressure fall.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: increased bleeding risk due to platelet inhibition.
  • Calcium channel blockers: may enhance hypotensive response.
  • Beta‑blockers: may mask tachycardia signs.

Frequently Asked Questions

Ilomedin 20 is indicated for the treatment of pulmonary arterial hypertension, digital ulcers associated with systemic sclerosis, and peripheral arterial disease. In each condition it helps improve blood flow by dilating affected vessels and reducing platelet aggregation.

Iloprost trometamol acts as a selective agonist of the prostacyclin (IP) receptor. Activation of this receptor raises intracellular cyclic AMP, causing smooth‑muscle relaxation, vasodilation, inhibition of platelet aggregation, and anti‑proliferative effects on the vascular wall.

The dosing regimen for Ilomedin 20 is individualized and set by the prescribing clinician based on the patient’s condition, severity, and response. Healthcare professionals determine the infusion rate, duration, and any titration steps.

Safety of Ilomedin 20 during pregnancy and lactation has not been established. It should be avoided unless the potential benefit justifies the potential risk to the fetus or infant, and it is used only under specialist supervision.

To order Ilomedin 20, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Ilomedin 20 (iloprost) is a synthetic prostacyclin analog that can be administered intravenously, offering rapid onset and easy titration. Compared with epoprostenol, iloprost has a longer half‑life and may be better tolerated, though both share similar vasodilatory and antiplatelet actions.

Ilomedin 20 should be stored at ambient temperature, preferably below 25 °C. Keep the vial in its original packaging, protect it from light, moisture and extreme temperatures, and avoid freezing.

Ilomedin 20 is given as an intravenous infusion. The solution is diluted according to the manufacturer’s instructions and administered over a controlled period, usually under continuous hemodynamic monitoring in a clinical setting.

The most serious adverse events include severe hypotension, pulmonary edema, and bleeding complications due to platelet inhibition. Prompt recognition and medical intervention are essential if these events occur.

Ilomedin 20 is contraindicated in patients with known hypersensitivity to iloprost or any component of the formulation, in those with uncontrolled severe hypotension, and in individuals where the risk of bleeding outweighs potential benefit.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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