Product image of Ilomedin (Iloprost Trometamol) supplied by GNH India

Ilomedin

Active Ingredient:
Iloprost Trometamol
Origin:
EU

Ilomedin (Iloprost Trometamol)

Iloprost Trometamol, the active ingredient in Ilomedin, is a prostacyclin analog presented as a solution for injection for intravenous use. It treats pulmonary arterial hypertension, peripheral arterial disease, and digital ulcers associated with systemic sclerosis. It is approved in the European Union for specialist use and is administered under medical supervision. The product complies with GMP standards and is distributed in sterile vials suitable for controlled infusion.

GNH India supplies Ilomedin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bayer Austria Gmbh

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Indications & Clinical Uses

Ilomedin (iloprost trometamol) is used in the management of vascular disorders characterized by vasoconstriction and platelet activation.

  • Pulmonary arterial hypertension: improves exercise capacity and reduces pulmonary arterial pressure.
  • Peripheral arterial disease: alleviates intermittent claudication and enhances limb perfusion.
  • Digital ulcers associated with systemic sclerosis: promotes ulcer healing and reduces new ulcer formation.
  • Raynaud's phenomenon secondary to systemic sclerosis: reduces frequency and severity of vasospastic attacks.

How It Works

  • Iloprost trometamol is a synthetic analogue of prostacyclin (PGI2). It binds to prostacyclin (IP) receptors on vascular smooth‑muscle cells and platelets, activating adenylate cyclase and increasing intracellular cyclic‑AMP. Elevated cAMP leads to relaxation of smooth‑muscle, vasodilation of pulmonary and systemic arteries, and inhibition of platelet aggregation. The compound also suppresses proliferation of vascular smooth‑muscle cells, contributing to its therapeutic effect in pulmonary hypertension and peripheral vascular disease.

Side Effects

Ilomedin may be associated with a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of the skin.
  • Nausea: occasional gastrointestinal upset.
  • Diarrhea: loose stools.
  • Jaw pain: discomfort in the mandibular area.
  • Hypotension: transient drop in blood pressure.

Serious or Rare Side Effects

  • Severe hypotension: marked blood pressure decline requiring intervention.
  • Pulmonary edema: fluid accumulation in the lungs.
  • Bleeding complications: significant hemorrhage due to antiplatelet effect.
  • Arrhythmias: abnormal heart rhythms.
  • Thrombocytopenia: low platelet count.
  • Anaphylaxis: acute allergic reaction.

Precautions & Warnings

When prescribing Ilomedin, clinicians should consider several safety and handling precautions.

  • Monitoring blood pressure: check systolic and diastolic values before and during infusion.
  • Assessing bleeding risk: evaluate for concurrent anticoagulants or coagulopathies.
  • Renal function: adjust use in patients with severe renal impairment.
  • Pregnancy and lactation: avoid use unless benefits outweigh potential risks.
  • Contraindications: do not use in patients with known hypersensitivity to iloprost or its excipients.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ilomedin can interact with other medicines, influencing its efficacy or safety profile.

Major Interactions (Avoid)

  • Concurrent use with potent vasodilators (e.g., nitroglycerin): may cause severe hypotension.
  • Combination with anticoagulants (e.g., warfarin, heparin): increased risk of bleeding.
  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): additive vasodilatory effect leading to hypotension.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may blunt antiplatelet effect.
  • Calcium channel blockers: potential additive blood pressure lowering.
  • Beta‑blockers: may mask tachycardia response during infusion.

Frequently Asked Questions

Ilomedin is indicated for pulmonary arterial hypertension, peripheral arterial disease, and digital ulcers associated with systemic sclerosis. In these conditions it helps to dilate blood vessels, improve blood flow, and reduce platelet aggregation, thereby alleviating symptoms and supporting tissue healing.

Iloprost trometamol mimics the natural prostacyclin (PGI2) molecule. By binding to IP receptors on vascular smooth‑muscle cells and platelets, it raises intracellular cyclic‑AMP levels, which causes smooth‑muscle relaxation, vasodilation, inhibition of platelet aggregation, and suppression of smooth‑muscle cell proliferation.

The dose of Ilomedin is individualized and determined by the prescribing physician based on the patient’s clinical condition, response, and tolerance. Dosing regimens are adjusted during therapy and should follow the prescriber’s specific instructions.

Safety data for Ilomedin in pregnancy and lactation are limited. It should be avoided unless the potential benefit to the mother clearly outweighs any possible risk to the fetus or infant. Consultation with a specialist is recommended before use.

To request Ilomedin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and any necessary import documentation.

Ilomedin (iloprost) is a short‑acting prostacyclin analog administered intravenously, whereas alternatives such as epoprostenol and treprostinil may be given by continuous infusion or inhalation. Iloprost offers the advantage of a defined infusion period and a well‑characterized safety profile, but selection depends on patient-specific factors and physician preference.

Ilomedin should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use to maintain sterility and potency.

Ilomedin is supplied as a sterile solution for injection and is administered intravenously under medical supervision. The infusion rate and duration are set by the treating physician and are typically monitored in a hospital or specialized clinic setting.

Serious adverse events include severe hypotension, pulmonary edema, significant bleeding, arrhythmias, thrombocytopenia, and rare anaphylactic reactions. Prompt recognition and management of these events are essential, and patients should be monitored closely during and after infusion.

Ilomedin is contraindicated in individuals with known hypersensitivity to iloprost or any of its excipients, in patients with uncontrolled severe hypotension, and in those for whom the risk of bleeding outweighs potential benefit. Clinical judgment should guide use in other special populations.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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