Product image of Ilomedin (Iloprost Trometamol) supplied by GNH India

Ilomedin

Active Ingredient:
Iloprost Trometamol
Origin:
EU

Ilomedin (Iloprost Trometamol)

Iloprost trometamol, the active ingredient in Ilomedin, is a prostacyclin analog presented as a sterile solution for injection for intravenous use. Marketed in the European Union, it is employed in the treatment of pulmonary arterial hypertension and to improve healing of digital ulcers associated with systemic sclerosis.

GNH India supplies Ilomedin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, providing reliable cold‑chain logistics and regulatory support, and ensuring product integrity throughout global distribution.

Manufacturer / TM Owner

Bayer Ab

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Indications & Clinical Uses

  • Ilomedin, a prostacyclin analog, acts on the pulmonary vascular system to improve hemodynamics in specific cardiopulmonary conditions.
  • Pulmonary arterial hypertension: reduces pulmonary arterial pressure and improves exercise capacity.
  • Digital ulcers associated with systemic sclerosis: promotes ulcer healing and reduces formation of new ulcers.

How It Works

  • Iloprost trometamol is a synthetic analogue of prostacyclin (PGI2) that selectively activates the prostacyclin (IP) receptor on vascular smooth‑muscle cells. IP‑receptor stimulation increases intracellular cyclic‑AMP, leading to potent vasodilation of pulmonary and systemic arteries and inhibition of platelet aggregation, thereby lowering pulmonary arterial pressure and improving microcirculatory blood flow. The elevated cAMP also reduces smooth‑muscle proliferation and exerts anti‑inflammatory effects within the pulmonary vasculature.

Side Effects

Ilomedin may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Flushing: warmth and redness of the skin.
  • Headache: mild to moderate intensity.
  • Nausea: occasional episodes.
  • Jaw pain: mild discomfort during chewing.
  • Diarrhea: mild gastrointestinal upset.
  • Hypotension: transient drop in blood pressure.

Serious or Rare Side Effects

  • Bleeding: due to platelet inhibition.
  • Severe hypotension: sustained low blood pressure requiring intervention.
  • Pulmonary edema: fluid accumulation in the lungs.
  • Arrhythmias: abnormal heart rhythms that may be life‑threatening.

Precautions & Warnings

When using Ilomedin, several precautions should be observed to ensure patient safety.

  • Dose titration: initiate at a low infusion rate and adjust gradually.
  • Hemodynamic monitoring: observe blood pressure and heart rate during infusion.
  • Renal impairment: use with caution in patients with reduced kidney function.
  • Concomitant anticoagulants: monitor for increased bleeding risk.
  • Pregnancy and lactation: safety not established; avoid unless benefit outweighs risk.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ilomedin can interact with other medicines; awareness of these interactions helps manage risk.

Major Interactions (Avoid)

  • Antiplatelet agents: additive inhibition of platelet function.
  • Potent vasodilators: may cause severe hypotension.
  • Epoprostenol: overlapping prostacyclin effects increase risk of adverse events.

Moderate Interactions (Monitor Closely)

  • CYP450 inhibitors: may increase plasma levels of iloprost.
  • CYP450 inducers: may reduce efficacy of iloprost.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may enhance bleeding risk.

Frequently Asked Questions

Ilomedin is indicated for the management of pulmonary arterial hypertension, where it helps lower pulmonary arterial pressure and improve exercise capacity, and for the treatment of digital ulcers associated with systemic sclerosis, promoting ulcer healing and reducing the occurrence of new ulcers.

Iloprost trometamol is a synthetic prostacyclin analogue that activates the IP (prostacyclin) receptor on vascular smooth‑muscle cells. This activation raises intracellular cyclic‑AMP, causing vasodilation, inhibition of platelet aggregation, and anti‑inflammatory effects, which together improve pulmonary hemodynamics and microcirculatory blood flow.

The dosing regimen for Ilomedin is individualized and set by the prescribing healthcare professional based on the patient's clinical condition, response, and tolerance. Specific infusion rates and duration are determined by the treating physician and may be adjusted during therapy.

Safety of Ilomedin in pregnancy and lactation has not been established. It should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a qualified healthcare provider.

To order Ilomedin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed) and the necessary import documentation.

Ilomedin (iloprost) is a short‑acting prostacyclin analogue administered intravenously, whereas agents such as epoprostenol and treprostinil have different routes (continuous IV or subcutaneous) and half‑lives. Iloprost offers the advantage of intermittent dosing and may be preferred in settings where continuous infusion is less practical, though efficacy and safety profiles are comparable across the class.

Ilomedin should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. The solution should be kept in its original container until use, and any unused portion should be discarded according to local regulations after the recommended storage period.

Ilomedin is supplied as a sterile solution for injection and is administered intravenously. The infusion is prepared according to the product’s instructions, typically using a dedicated infusion set, and delivered over a prescribed period under continuous monitoring of vital signs and hemodynamic parameters.

The most serious adverse events linked to Ilomedin include severe hypotension, significant bleeding due to platelet inhibition, pulmonary edema, and potentially life‑threatening arrhythmias. Prompt recognition and management of these events are essential, and patients should be monitored closely during and after infusion.

Ilomedin is contraindicated in patients with known hypersensitivity to iloprost or any component of the formulation. Caution is advised in individuals with uncontrolled severe hypotension, active bleeding disorders, recent major surgery, or those receiving concurrent potent vasodilators without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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