Product image of Ilomedin (Iloprost Trometamol) supplied by GNH India

Ilomedin

Active Ingredient:
Iloprost Trometamol
Origin:
EU

Ilomedin (Iloprost Trometamol)

Iloprost Trometamol, the active ingredient in Ilomedin, is a prostacyclin analog presented as a solution for injection for intravenous use. It treats pulmonary arterial hypertension and digital ulcers associated with systemic sclerosis.

GNH India supplies Ilomedin as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bayer Ag

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Indications & Clinical Uses

  • Ilomedin, a prostacyclin analog, is used in conditions affecting the pulmonary vasculature and microcirculation.
  • Pulmonary arterial hypertension: improves exercise capacity and hemodynamic parameters.
  • Digital ulcers associated with systemic sclerosis: promotes ulcer healing and reduces new ulcer formation.

How It Works

  • Iloprost Trometamol binds to prostacyclin (IP) receptors on vascular smooth‑muscle cells, activating adenylate cyclase and increasing intracellular cyclic AMP. Elevated cAMP leads to relaxation of pulmonary and systemic arteries, producing vasodilation, and simultaneously inhibits platelet aggregation, contributing to improved blood flow in affected vascular beds.

Side Effects

Ilomedin may cause a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects

  • Headache
  • Flushing
  • Nausea
  • Jaw pain
  • Hypotension
  • Infusion site pain

Serious or Rare Side Effects

  • Severe hypotension
  • Pulmonary edema
  • Bleeding complications
  • Thrombocytopenia
  • Cardiac arrhythmias

Precautions & Warnings

  • Prior to initiating Ilomedin therapy, several precautions should be observed to ensure patient safety.
  • Monitor blood pressure: watch for hypotension during and after infusion.
  • Assess bleeding risk: avoid in patients with active hemorrhage or uncontrolled coagulopathy.
  • Pregnancy considerations: limited data; use only if potential benefit justifies potential risk.
  • Hepatic impairment: adjust monitoring as drug clearance may be reduced.
  • Concomitant vasodilators: avoid combined use with other potent vasodilators to prevent additive hypotension.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ilomedin can interact with other medicines, affecting its safety or efficacy.

Major Interactions (Avoid)

  • Other prostacyclin analogs: additive vasodilatory effects may cause severe hypotension.
  • Phosphodiesterase‑5 inhibitors: increased risk of marked blood pressure reduction.
  • Anticoagulants: heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

  • Nitrates: may enhance vasodilation and cause hypotension.
  • Beta‑blockers: may blunt desired hemodynamic response.

Frequently Asked Questions

Ilomedin is indicated for the treatment of pulmonary arterial hypertension, where it helps lower pulmonary arterial pressure and improve exercise capacity, and for digital ulcers associated with systemic sclerosis, where it promotes ulcer healing and reduces the formation of new ulcers.

Iloprost Trometamol acts as an agonist at prostacyclin (IP) receptors on vascular smooth‑muscle cells. Activation of these receptors raises cyclic AMP levels, causing vasodilation of pulmonary and systemic arteries and inhibiting platelet aggregation, which together improve blood flow in affected vessels.

The dose of Ilomedin is individualized by the prescribing clinician based on the patient’s disease severity, response to therapy, and tolerance. Dosing regimens are adjusted according to clinical monitoring of hemodynamic parameters and adverse‑effect profile.

Safety data for Ilomedin in pregnancy and lactation are limited. It is classified as having an unknown pregnancy category, and use is generally avoided unless the potential benefit justifies the potential risk to the fetus. Breastfeeding decisions should be made in consultation with a healthcare professional.

To order Ilomedin, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Ilomedin (iloprost trometamol) is a synthetic prostacyclin analog administered intravenously, offering rapid onset of vasodilation. Compared with inhaled or oral prostacyclin agents, it provides more controlled systemic exposure but requires infusion equipment and careful monitoring for hypotension and bleeding.

Ilomedin should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. Before use, allow the solution to reach room temperature if required for infusion, and inspect for particulate matter or discoloration.

Ilomedin is given as an intravenous infusion. The prescribing clinician determines the infusion rate and duration, which are typically titrated based on blood pressure response and tolerance. Infusion sets and sterile techniques must be used according to institutional protocols.

The most serious risks include severe hypotension, pulmonary edema, significant bleeding, thrombocytopenia, and cardiac arrhythmias. These events require immediate medical attention and may necessitate discontinuation of therapy.

Ilomedin is contraindicated in patients with active uncontrolled bleeding, severe hypotension, known hypersensitivity to iloprost or any formulation component, and in those where the risk of vasodilation outweighs potential benefit, such as certain unstable cardiac conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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