Product image of Ilomedin (Iloprost Trometamol) supplied by GNH India

Ilomedin

Active Ingredient:
Iloprost Trometamol
Origin:
EU

Ilomedin (Iloprost Trometamol)

Iloprost trometamol, the active ingredient in Ilomedin, is a prostacyclin analog presented as a solution for injection for intravenous use. It treats pulmonary arterial hypertension, digital ulcers associated with systemic sclerosis, and helps prevent vasospasm in peripheral vascular surgery.

GNH India supplies Ilomedin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bayer Portugal Lda

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Indications & Clinical Uses

Ilomedin, a prostacyclin analog, is used in conditions characterized by pulmonary vascular resistance or peripheral vasospasm.

  • Pulmonary arterial hypertension: improves exercise capacity and delays disease progression.
  • Digital ulcers associated with systemic sclerosis: promotes ulcer healing and reduces new ulcer formation.
  • Prevention of vasospasm in peripheral vascular surgery: maintains vessel patency during and after surgical procedures.

How It Works

  • Iloprost trometamol acts as a selective agonist at the IP (prostacyclin) receptor on vascular smooth‑muscle cells. Activation of this receptor stimulates cyclic AMP formation, leading to potent vasodilation, inhibition of platelet aggregation, and antiproliferative effects on the pulmonary arterial wall, thereby reducing vascular resistance and improving blood flow.

Side Effects

Adverse reactions may occur with Ilomedin administration.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of the skin.
  • Nausea: occasional gastrointestinal upset.
  • Jaw pain: discomfort during mastication.
  • Hypotension: mild drop in blood pressure.
  • Cough: dry or productive.

Serious or Rare Side Effects

  • Severe hypotension: marked blood pressure decline requiring intervention.
  • Pulmonary edema: fluid accumulation in the lungs.
  • Significant bleeding: due to platelet inhibition.
  • Thrombocytopenia: reduced platelet count.
  • Arrhythmia: abnormal heart rhythm.
  • Anaphylaxis: rare severe allergic reaction.

Precautions & Warnings

Careful monitoring is required when using Ilomedin.

  • Blood pressure monitoring: check before and during infusion.
  • Bleeding risk assessment: evaluate patients on anticoagulants.
  • Severe hypotension avoidance: do not administer to patients with unstable hemodynamics.
  • Pregnancy caution: use only if potential benefit justifies risk.
  • Renal/hepatic impairment: adjust therapy based on clinical response.
  • Storage: Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ilomedin may interact with other medications affecting vascular tone or coagulation.

Major Interactions (Avoid)

  • Concurrent potent vasodilators: risk of profound hypotension.
  • Anticoagulants/antiplatelet agents: increased bleeding tendency.
  • Endothelin receptor antagonists: additive pulmonary vasodilatory effect.

Moderate Interactions (Monitor Closely)

  • Aspirin or NSAIDs: may enhance bleeding risk.
  • Other prostacyclin analogs: potential for overlapping side‑effects.
  • CYP450 inhibitors: may alter metabolism, requiring observation.

Frequently Asked Questions

Ilomedin is indicated for pulmonary arterial hypertension, digital ulcers associated with systemic sclerosis, and for preventing vasospasm during peripheral vascular surgery. In each case, the drug helps to dilate blood vessels and improve blood flow.

Iloprost trometamol selectively activates the IP (prostacyclin) receptor on vascular smooth‑muscle cells. This activation raises cyclic AMP levels, causing vasodilation, inhibition of platelet aggregation, and antiproliferative effects that lower vascular resistance.

The dosing regimen for Ilomedin is individualized. A qualified prescriber determines the appropriate dose, infusion rate, and duration based on the patient’s condition, response, and tolerance.

Safety data for Ilomedin in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To order Ilomedin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required), and import documentation.

Ilomedin belongs to the prostacyclin analog class, offering potent vasodilation and antiplatelet effects. Compared with oral endothelin receptor antagonists or phosphodiesterase‑5 inhibitors, Ilomedin provides rapid intravenous action, which can be advantageous in acute or severe cases but requires careful monitoring and infusion equipment.

Ilomedin should be stored at 2‑8 °C in a refrigerator. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution to maintain stability.

Ilomedin is supplied as a sterile solution for injection and is administered intravenously. The infusion is typically delivered through a controlled infusion pump over a prescribed period, under the supervision of qualified healthcare personnel.

The most serious risks include severe hypotension, pulmonary edema, significant bleeding, thrombocytopenia, and rare anaphylactic reactions. Patients should be closely monitored for these events, especially during the initial infusion period.

Ilomedin is contraindicated in patients with known hypersensitivity to iloprost or any component of the formulation, and in those with uncontrolled severe hypotension. Caution is also advised for individuals with active bleeding disorders or recent major surgery.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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