Product image of Ilomedin (Iloprost Trometamol) supplied by GNH India

Ilomedin

Active Ingredient:
Iloprost Trometamol
Origin:
EU

Ilomedin (Iloprost Trometamol)

Iloprost trometamol, the active ingredient in Ilomedin, is a prostacyclin analog presented as an injectable solution for intravenous use. It is indicated for the treatment of pulmonary arterial hypertension and for digital ulcers associated with systemic sclerosis in adult patients.
GNH India supplies Ilomedin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bayer D.O.O

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Indications & Clinical Uses

  • Ilomedin is a prostacyclin analog used in the management of vascular disorders affecting the pulmonary circulation and skin microvasculature.
  • Pulmonary arterial hypertension: improves exercise capacity and reduces pulmonary vascular resistance.
  • Digital ulcers associated with systemic sclerosis: promotes ulcer healing and reduces the formation of new ulcers.

How It Works

  • Iloprost trometamol is a synthetic analogue of prostacyclin (PGI2) that selectively activates prostacyclin (IP) receptors on vascular smooth‑muscle cells. Receptor activation increases cyclic AMP levels, leading to potent vasodilation, inhibition of platelet aggregation, and antiproliferative effects on the pulmonary arterial wall.

Side Effects

Ilomedin may cause a range of adverse reactions, most of which are related to its vasodilatory activity.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of the skin.
  • Nausea: occasional gastrointestinal upset.
  • Jaw pain: discomfort during chewing.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical intervention.
  • Pulmonary edema: accumulation of fluid in the lungs.
  • Bleeding complications: increased risk of hemorrhage, especially when combined with anticoagulants.

Precautions & Warnings

  • Before initiating Ilomedin therapy, clinicians should consider several safety measures.
  • Monitor blood pressure: check regularly due to potent vasodilatory effect.
  • Assess bleeding risk: avoid in patients with active hemorrhage or uncontrolled coagulopathy.
  • Evaluate renal function: adjust therapy if significant impairment is present.
  • Avoid concurrent prostacyclin analogs: combined use may amplify adverse effects.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ilomedin can interact with other medications that influence vascular tone or coagulation.

Major Interactions (Avoid)

  • Concomitant nitrates or other vasodilators: may cause severe hypotension.
  • Anticoagulants (e.g., warfarin, heparin): increased risk of bleeding.
  • Phosphodiesterase inhibitors: potentiation of vasodilatory response.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs: may affect renal function.
  • Calcium channel blockers: additive hypotensive effect.
  • Beta‑blockers: may mask tachycardia associated with vasodilation.

Frequently Asked Questions

Ilomedin is an intravenous prostacyclin analogue prescribed to manage pulmonary arterial hypertension, helping to lower pulmonary arterial pressure and improve exercise tolerance. It is also used to treat digital ulcers in patients with systemic sclerosis, where it promotes ulcer healing and reduces the occurrence of new lesions.

Iloprost trometamol mimics the natural prostacyclin molecule by binding to IP receptors on vascular smooth‑muscle cells. Activation of these receptors raises intracellular cyclic AMP, causing the blood vessels to relax (vasodilation) and inhibiting platelet aggregation, which together improve blood flow in the pulmonary circulation and skin microvasculature.

The dosing regimen for Ilomedin is individualized and determined by the prescribing physician based on the patient’s clinical condition, response, and tolerance. Healthcare professionals adjust the infusion rate and duration to achieve the desired therapeutic effect while monitoring safety parameters.

Safety data for Ilomedin during pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks with their healthcare provider.

To order Ilomedin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics if needed), and required import documentation.

Ilomedin (iloprost trometamol) is a short‑acting prostacyclin analogue administered intravenously, offering rapid titration and reversible effects. Compared with longer‑acting agents such as epoprostenol or treprostinil, iloprost allows more flexible dosing schedules but may require more frequent infusions. Choice of therapy depends on patient preference, disease severity, and logistical considerations.

Ilomedin must be stored refrigerated at 2‑8 °C. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution. Before use, inspect the product for any particulate matter or discoloration and follow aseptic techniques for preparation and administration.

Ilomedin is supplied as a sterile injectable solution for intravenous infusion. It is administered through a controlled infusion pump or syringe driver under the supervision of qualified healthcare personnel. The infusion rate is gradually increased during the initial titration phase to achieve the target therapeutic response while monitoring vital signs.

The most serious adverse events associated with Ilomedin include severe hypotension, which can lead to syncope or organ hypoperfusion, pulmonary edema, and significant bleeding, especially when used with anticoagulants. Prompt recognition of these signs and immediate medical intervention are essential to mitigate complications.

Ilomedin is contraindicated in patients with known hypersensitivity to iloprost or any component of the formulation. It should also be avoided in individuals with active uncontrolled bleeding, severe hypotension, or those receiving other prostacyclin analogues without careful medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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