Product image of Iloprost (Iloprost Trometamol) supplied by GNH India

Iloprost

Active Ingredient:
Iloprost Trometamol
Origin:
EU

Iloprost (Iloprost Trometamol)

Iloprost, the active ingredient in Iloprost, is a prostacyclin analog presented as a sterile solution for injection for intravenous use. It is indicated for the management of pulmonary arterial hypertension and for the treatment of digital ulcers associated with systemic sclerosis.

GNH India supplies Iloprost as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution across EU and other regulated markets. All batches are manufactured under GMP conditions and undergo rigorous quality testing before release.

Manufacturer / TM Owner

Waymade B.V.

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Indications & Clinical Uses

Iloprost is a prostacyclin analog used in vascular disorders that affect the pulmonary circulation and peripheral microvasculature.

  • Pulmonary arterial hypertension: improves exercise capacity and reduces pulmonary vascular resistance.
  • Digital ulcers associated with systemic sclerosis: promotes ulcer healing and reduces new ulcer formation.
  • Pulmonary hypertension (general): provides vasodilation to lower pulmonary arterial pressure.

How It Works

  • Iloprost selectively activates prostacyclin (IP) receptors on vascular smooth‑muscle cells, leading to increased cyclic AMP levels. This cascade causes potent vasodilation of pulmonary and systemic arteries and inhibits platelet aggregation, thereby improving blood flow and reducing vascular resistance in affected tissues.

Side Effects

Adverse reactions may occur with Iloprost therapy.

Common Side Effects

  • Headache
  • Flushing
  • Nausea
  • Hypotension

Serious or Rare Side Effects

  • Pulmonary edema
  • Severe hypotension
  • Bleeding complications

Precautions & Warnings

Use Iloprost with careful clinical monitoring.

  • Monitor blood pressure: check regularly for hypotension.
  • Assess bleeding risk: avoid in patients with active hemorrhage.
  • Use caution in renal impairment: adjust monitoring as needed.
  • Avoid use in pregnancy: safety not established.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Iloprost may interact with other medicines.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Epoprostenol: additive vasodilatory effect leading to severe hypotension.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may enhance hypotensive effect.
  • Beta‑blockers: may mask tachycardia.
  • Diuretics: may exacerbate hypotension.

Frequently Asked Questions

Iloprost is prescribed for pulmonary arterial hypertension to lower pulmonary arterial pressure and improve exercise capacity, and for digital ulcers associated with systemic sclerosis to promote healing and reduce new ulcer formation.

Iloprost acts as a selective prostacyclin (IP) receptor agonist. Activation of these receptors raises cyclic AMP in vascular smooth‑muscle cells, causing vasodilation and inhibiting platelet aggregation, which improves blood flow in the pulmonary circulation and peripheral vessels.

The dosing regimen for Iloprost is individualized. A qualified prescriber determines the appropriate infusion rate, concentration, and duration based on the patient’s clinical condition, response, and tolerance.

Safety data for Iloprost in pregnancy and lactation are limited. The product is classified as pregnancy category unknown, and it is generally advised to avoid use unless the potential benefit justifies the potential risk to the fetus or infant.

To request Iloprost, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Iloprost is a synthetic prostacyclin analog administered intravenously, offering rapid onset and short half‑life. Compared with longer‑acting agents like epoprostenol, Iloprost may allow more flexible infusion schedules but requires careful monitoring for hypotension and bleeding.

Iloprost solution for injection should be stored refrigerated at 2‑8 °C. Keep the vial in its original packaging, protect it from light, and do not freeze or shake the product before use.

Iloprost is given as an intravenous infusion. The solution is diluted according to the prescriber’s instructions and administered via a controlled infusion pump over a prescribed period, typically in a clinical setting with continuous monitoring.

Serious risks include severe hypotension, pulmonary edema, and bleeding complications. Patients should be monitored closely for sudden drops in blood pressure, signs of fluid overload, and any unexpected bleeding during treatment.

Iloprost is contraindicated in patients with active bleeding, uncontrolled severe hypotension, or known hypersensitivity to the drug or its excipients. Caution is also advised for individuals with severe renal impairment or during pregnancy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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