Product image of Iloprost Pharmamentum (Iloprost Trometamol) supplied by GNH India

Iloprost Pharmamentum

Active Ingredient:
Iloprost Trometamol
Origin:
EU

Iloprost Pharmamentum (Iloprost Trometamol)

Iloprost, the active ingredient in Iloprost Pharmamentum, is a prostacyclin analog presented as a solution for injection for intravenous use. It treats pulmonary arterial hypertension and digital ulcers associated with systemic sclerosis.\n\nGNH India supplies Iloprost Pharmamentum as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharmanovia A/S

1
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Indications & Clinical Uses

  • Iloprost acts on the prostacyclin pathway to manage severe pulmonary vascular disease and related complications.\n\nPulmonary arterial hypertension: improves exercise capacity and lowers pulmonary arterial pressure.\nDigital ulcers associated with systemic sclerosis: promotes ulcer healing and reduces new ulcer formation.\nPulmonary hypertension (including chronic thromboembolic forms): reduces pulmonary vascular resistance and may improve symptoms.

How It Works

  • Iloprost mimics endogenous prostacyclin (PGI2) and selectively activates the IP receptor on vascular smooth‑muscle cells. Receptor activation stimulates adenylate cyclase, increasing intracellular cAMP, which leads to vasodilation, inhibition of platelet aggregation, and antiproliferative effects on the pulmonary arterial wall.

Side Effects

  • Iloprost may cause a range of adverse reactions, most of which are dose‑related and transient.\n\nCommon Side Effects:\n- Headache: mild to moderate, often early in therapy.\n- Flushing: warm sensation, usually transient.\n- Nausea or vomiting: gastrointestinal upset.\n- Jaw pain or toothache: mimics angina‑like discomfort.\n- Diarrhea: loose stools, generally self‑limiting.\n- Hypotension: mild drop in blood pressure, especially with rapid infusion.\n\nSerious or Rare Side Effects:\n- Severe hypotension or shock: marked blood pressure fall requiring medical intervention.\n- Bleeding complications: increased risk when combined with anticoagulants.\n- Pulmonary edema: fluid accumulation in lungs, rare but serious.\n- Thrombocytopenia: low platelet count, may predispose to bleeding.\n- Arrhythmias: abnormal heart rhythms, especially in patients with cardiac disease.\n- Anaphylactic reaction: rare hypersensitivity requiring immediate treatment.

Precautions & Warnings

  • Before initiating Iloprost, clinicians should assess patient‑specific risk factors and monitor for potential complications.\n\nMonitor blood pressure: watch for hypotension during and after infusion.\nAssess bleeding risk: avoid in patients with active hemorrhage or uncontrolled coagulopathy.\nUse cautiously in renal impairment: dose adjustment may be required.\nAvoid in recent myocardial infarction: risk of further ischemia.\nPregnancy and lactation: safety not established; weigh benefits against potential risks.\nStore at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

  • Iloprost can interact with several drug classes, altering its safety profile or efficacy.\n\nMajor Interactions (Avoid):\n- Concomitant prostacyclin analogs: additive vasodilation may cause severe hypotension.\n- Potent vasodilators (e.g., nitroglycerin): risk of profound blood pressure drop.\n- Anticoagulants (e.g., warfarin, heparin): increased bleeding tendency.\n\nModerate Interactions (Monitor Closely):\n- CYP450 inhibitors (e.g., erythromycin): may modestly raise Iloprost exposure.\n- CYP450 inducers (e.g., rifampicin): may reduce therapeutic effect.\n- Diuretics: may enhance hypotensive effect, requiring blood pressure monitoring.

Frequently Asked Questions

Iloprost Pharmamentum is indicated for the treatment of pulmonary arterial hypertension and for digital ulcers associated with systemic sclerosis. In both conditions it works by dilating pulmonary vessels and improving blood flow, which can relieve symptoms and support healing.

Iloprost mimics the natural prostacyclin (PGI2) and binds to the IP receptor on vascular smooth‑muscle cells. This activates adenylate cyclase, raises intracellular cAMP, and leads to vasodilation, inhibition of platelet aggregation, and antiproliferative effects on the pulmonary arterial wall.

The dosage and infusion rate of Iloprost Pharmamentum are determined by the prescribing physician based on the patient’s clinical condition, response, and tolerance. The prescriber will set the appropriate regimen and adjust it as needed during therapy.

Safety of Iloprost in pregnancy and lactation has not been established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Iloprost belongs to the prostacyclin analog class, offering vasodilation and antiplatelet effects. Compared with oral endothelin‑receptor antagonists, Iloprost provides rapid hemodynamic improvement via intravenous infusion, but requires careful monitoring and specialized delivery equipment.

Iloprost Pharmamentum must be stored at 2‑8 °C, protected from light, and should not be frozen or shaken. Keep the product in its original packaging until ready for use to maintain stability.

Iloprost Pharmamentum is supplied as a sterile solution for injection and is administered intravenously, usually via a controlled infusion pump. The infusion rate and duration are set by the healthcare professional according to the prescribed regimen.

Serious risks include severe hypotension, bleeding complications (especially when combined with anticoagulants), pulmonary edema, thrombocytopenia, and rare anaphylactic reactions. Patients should be monitored closely for these events, particularly during initiation and dose adjustments.

Iloprost is contraindicated in patients with known hypersensitivity to iloprost or any component of the formulation, those with active uncontrolled bleeding, and individuals who have experienced severe hypotension with previous prostacyclin therapy. Clinical judgment is required for other special populations.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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