Product image of Iloprost Pharmamentum (Iloprost Trometamol) supplied by GNH India

Iloprost Pharmamentum

Active Ingredient:
Iloprost Trometamol
Origin:
EU

Iloprost Pharmamentum (Iloprost Trometamol)

Iloprost Trometamol, the active ingredient in Iloprost Pharmamentum, is a prostacyclin analog presented as a intravenous solution for intravenous use. It treats pulmonary arterial hypertension and related vascular conditions in adult patients.\n\nGNH India supplies Iloprost Pharmamentum as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Waymade B.V.

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Indications & Clinical Uses

  • Iloprost Pharmamentum, a prostacyclin analog, is used in conditions involving pulmonary vascular dysfunction.\n\nPulmonary arterial hypertension: lowers pulmonary arterial pressure, improves exercise capacity and functional class.\nDigital ulcers: enhances microvascular blood flow to promote healing of ischemic skin lesions.\nRaynaud's phenomenon: reduces frequency and severity of vasospastic attacks by dilating peripheral arteries.

How It Works

  • Iloprost Trometamol acts as an agonist at prostacyclin (IP) receptors on vascular smooth‑muscle cells, triggering cyclic AMP accumulation. Elevated cAMP leads to vasodilation of pulmonary and systemic arteries and inhibits platelet aggregation, thereby improving blood flow and reducing vascular resistance in affected tissues.

Side Effects

  • Iloprost may cause a range of adverse reactions, from mild to severe.\n\nCommon Side Effects:\n- Headache: transient throbbing pain often occurring during infusion.\n- Flushing: warm sensation and reddening of the skin, especially on the face and neck.\n- Nausea: mild gastrointestinal upset that may resolve with continued therapy.\n- Hypotension: modest drop in blood pressure, usually manageable.\n- Jaw pain: discomfort in the mandibular area during infusion.\n\nSerious or Rare Side Effects:\n- Severe hypotension: marked blood pressure decline requiring medical intervention.\n- Pulmonary edema: accumulation of fluid in the lungs presenting with dyspnea.\n- Bleeding complications: increased risk of hemorrhage due to platelet inhibition.\n- Thrombocytopenia: significant reduction in platelet count.\n- Cardiac arrhythmias: irregular heart rhythms that may be life‑threatening.

Precautions & Warnings

  • When using Iloprost Pharmamentum, clinicians should observe several safety measures.\n\nMonitor blood pressure: check regularly during and after infusion.\nAssess bleeding risk: avoid in patients with active hemorrhage or severe coagulopathy.\nAdjust dose in renal impairment: consider reduced clearance in severe kidney dysfunction.\nAvoid concomitant potent vasodilators: may amplify hypotensive effects.\nUse under specialist supervision: administration should be managed by experienced healthcare professionals.\nStore at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

  • Iloprost can interact with other medicines, requiring careful management.\n\nMajor Interactions (Avoid):\n- Potent vasodilators (e.g., nitroglycerin): may cause dangerous hypotension.\n- Anticoagulants (e.g., warfarin, heparin): increased risk of bleeding.\n- Endothelin receptor antagonists: additive pulmonary vasodilatory effect.\n\nModerate Interactions (Monitor Closely):\n- Calcium channel blockers: may enhance vasodilatory response.\n- Aspirin or other antiplatelet agents: monitor for excessive bleeding.\n- Non‑steroidal anti‑inflammatory drugs (NSAIDs): may affect renal function and platelet activity.

Frequently Asked Questions

Iloprost Pharmamentum is indicated for the treatment of pulmonary arterial hypertension, digital ulcers, and Raynaud's phenomenon. It works by dilating blood vessels and inhibiting platelet aggregation, helping to improve blood flow in these vascular conditions.

Iloprost Trometamol is a prostacyclin (IP) receptor agonist. By binding to these receptors on vascular smooth‑muscle cells, it raises cyclic AMP levels, causing vasodilation and reducing platelet aggregation, which together lower pulmonary arterial pressure and improve tissue perfusion.

The dosing regimen for Iloprost Pharmamentum is individualized. A qualified prescriber determines the appropriate dose, infusion rate, and treatment duration based on the patient’s clinical condition, response, and tolerance.

Safety data for Iloprost in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Iloprost is a prostacyclin analog, offering rapid vasodilatory effects via IP‑receptor activation. Compared with endothelin receptor antagonists or phosphodiesterase‑5 inhibitors, Iloprost provides a distinct mechanism and is often used when patients need additional or alternative vasodilation, especially in advanced disease.

Iloprost Pharmamentum must be stored refrigerated at 2‑8 °C, protected from light, and never frozen or shaken. Use aseptic techniques during preparation and keep the product in its original packaging until administration.

Iloprost Pharmamentum is given by intravenous infusion under the supervision of qualified healthcare professionals. The infusion rate and duration are set by the prescriber and may be adjusted based on the patient’s hemodynamic response and tolerability.

Serious risks include severe hypotension, pulmonary edema, significant bleeding, thrombocytopenia, and cardiac arrhythmias. Patients should be monitored closely for these events, especially during initiation and dose adjustments.

Iloprost is contraindicated in patients with known hypersensitivity to iloprost or any component of the formulation, those with active uncontrolled bleeding, severe hypotension, or in whom potent vasodilators are contraindicated. Clinical judgment is required for each individual case.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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