Product image of Iloprost Rafarm (Iloprost) supplied by GNH India

Iloprost Rafarm

Active Ingredient:
Iloprost
Origin:
EU

Iloprost Rafarm (Iloprost)

Iloprost, the active ingredient in Iloprost Rafarm, is a prostacyclin analog presented as an inhalation solution for inhalation use. It is employed in the management of pulmonary arterial hypertension and in the treatment of digital ulcers associated with systemic sclerosis, helping to improve vascular tone and promote ulcer healing.

GNH India supplies Iloprost Rafarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support global distribution.

Manufacturer / TM Owner

Rafarm Sa.

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Indications & Clinical Uses

  • Iloprost, a prostacyclin analog, targets the prostacyclin (IP) receptor to produce vasodilation and inhibit platelet aggregation, making it useful in diseases characterized by pulmonary vascular constriction and microvascular injury.
  • Pulmonary arterial hypertension: reduces pulmonary vascular resistance, improves hemodynamics, and enhances exercise tolerance and functional class.
  • Digital ulcers associated with systemic sclerosis: increases blood flow to ischemic skin, accelerates ulcer closure, and lowers the incidence of new ulcer development.

How It Works

  • Iloprost is a selective agonist of the prostacyclin (IP) receptor on vascular smooth‑muscle cells. Activation of this G‑protein‑coupled receptor stimulates adenylate cyclase, raising intracellular cyclic‑AMP levels, which leads to relaxation of pulmonary arterial smooth muscle and vasodilation. The elevated cAMP also inhibits platelet activation and aggregation, contributing to improved microcirculatory flow in affected tissues.

Side Effects

Iloprost may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Cough
  • Throat irritation
  • Headache
  • Flushing

Serious or Rare Side Effects

  • Severe hypotension
  • Pulmonary edema
  • Significant bleeding
  • Bronchospasm

Precautions & Warnings

When prescribing Iloprost, clinicians should consider several safety measures to minimize risk.

  • Monitor blood pressure: check for hypotension before and during therapy.
  • Assess bleeding risk: evaluate concomitant anticoagulant use and history of hemorrhage.
  • Evaluate pulmonary function: watch for bronchospasm in patients with reactive airway disease.
  • Avoid use in recent hemoptysis: contraindicated in active pulmonary bleeding.
  • Use with caution in hepatic impairment: adjust therapy based on liver function.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Iloprost can interact with other medicines, altering its vasodilatory effect or bleeding risk.

Major Interactions (Avoid)

  • Concomitant potent vasodilators (e.g., nitroglycerin): may cause severe hypotension.
  • Anticoagulants (e.g., warfarin, heparin): increase risk of bleeding.
  • Other prostacyclin analogs: additive vasodilatory effects.
  • Endothelin receptor antagonists: may enhance pulmonary vasodilation excessively.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may potentiate blood pressure lowering.
  • Phosphodiesterase‑5 inhibitors: could increase pulmonary vasodilation.
  • NSAIDs: may affect platelet function and increase bleeding tendency.

Frequently Asked Questions

Iloprost Rafarm is indicated for the treatment of pulmonary arterial hypertension, where it helps lower pulmonary arterial pressure and improve exercise capacity, and for digital ulcers associated with systemic sclerosis, where it promotes ulcer healing and reduces the formation of new ulcers.

Iloprost acts as a selective agonist of the prostacyclin (IP) receptor on vascular smooth‑muscle cells. By stimulating this receptor, it raises intracellular cyclic‑AMP, causing relaxation of pulmonary arteries, vasodilation, and inhibition of platelet aggregation, which together improve blood flow in affected vascular beds.

The dose of Iloprost Rafarm is individualized and set by the prescribing healthcare professional based on the patient’s clinical condition, response to therapy, and tolerability. Specific dosing regimens are not provided here and should follow the prescriber’s instructions and local labeling.

Safety data for Iloprost in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician in consultation with the patient.

To place an order, submit an enquiry on the Iloprost Rafarm product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and clinics worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and the necessary import documentation.

Iloprost belongs to the prostacyclin analog class, offering potent vasodilation and antiplatelet effects. Compared with endothelin receptor antagonists or phosphodiesterase‑5 inhibitors, it provides a direct prostacyclin pathway activation. Choice of therapy depends on disease severity, route‑of‑administration preferences, and individual patient response.

Iloprost Rafarm should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, light, and extreme temperature fluctuations to maintain stability and potency.

Iloprost Rafarm is administered by inhalation using a compatible nebulizer device. The patient inhales the prescribed dose as directed by the healthcare provider, typically several times per day, with each inhalation session lasting a few minutes.

The most serious adverse events include severe hypotension, pulmonary edema, significant bleeding, and bronchospasm. Patients should be monitored closely for these reactions, especially during dose initiation and titration, and any signs of serious complications require immediate medical attention.

Iloprost Rafarm is contraindicated in patients with recent hemoptysis, uncontrolled severe hypotension, active pulmonary infection, or known hypersensitivity to iloprost or any formulation component. Caution is also advised for individuals with severe hepatic impairment or unstable cardiac conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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