Product image of Iloprost Ratiopharm (Iloprost) supplied by GNH India

Iloprost Ratiopharm

Active Ingredient:
Iloprost
Origin:
EU

Iloprost Ratiopharm (Iloprost)

Iloprost, the active ingredient in Iloprost Ratiopharm, is a prostacyclin analog presented as a intravenous solution for intravenous use. It treats pulmonary arterial hypertension and digital ulcers associated with systemic sclerosis in adult patients.

GNH India supplies Iloprost Ratiopharm as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ratiopharm Gmbh

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Indications & Clinical Uses

  • Iloprost acts on the prostacyclin pathway to manage severe vascular conditions.
  • Pulmonary arterial hypertension: reduces pulmonary arterial pressure and improves functional capacity.
  • Digital ulcers associated with systemic sclerosis: promotes ulcer healing and reduces pain.

How It Works

  • Iloprost is a prostacyclin (PGI2) receptor agonist that binds to IP receptors on vascular smooth‑muscle cells, causing cyclic AMP‑mediated vasodilation and inhibition of platelet aggregation, thereby lowering pulmonary vascular resistance and improving blood flow to affected tissues.

Side Effects

Iloprost may cause a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of the skin.
  • Jaw pain: discomfort during chewing.
  • Nausea or vomiting: gastrointestinal upset.
  • Diarrhea: loose stools.
  • Hypotension: temporary drop in blood pressure.

Serious or Rare Side Effects

  • Severe hypotension: may require medical intervention.
  • Pulmonary edema: accumulation of fluid in the lungs.
  • Bleeding complications: especially when combined with anticoagulants.
  • Thrombocytopenia: reduced platelet count.
  • Chest pain or myocardial ischemia: rare cardiac events.

Precautions & Warnings

  • Iloprost requires careful monitoring and specific handling precautions.
  • Monitor blood pressure: watch for symptomatic hypotension.
  • Assess bleeding risk: avoid in patients with active hemorrhage.
  • Use caution in pulmonary edema: discontinue if fluid overload occurs.
  • Avoid in severe coronary artery disease: risk of myocardial ischemia.
  • Pregnancy and lactation: safety not established; use only if benefit outweighs risk.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Iloprost can interact with several drug classes.

Major Interactions (Avoid)

  • Concomitant potent vasodilators (e.g., nitroglycerin): may cause severe hypotension.
  • Anticoagulants (e.g., warfarin, heparin): increased risk of bleeding.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may diminish antiplatelet effect.
  • Calcium channel blockers: additive vasodilatory response.
  • Other prostacyclin analogs (e.g., epoprostenol): potential for excessive pulmonary vasodilation.

Frequently Asked Questions

Iloprost Ratiopharm is indicated for the treatment of pulmonary arterial hypertension, where it helps lower pulmonary arterial pressure, and for digital ulcers associated with systemic sclerosis, where it promotes ulcer healing and reduces pain.

Iloprost acts as an agonist at prostacyclin (IP) receptors on vascular smooth‑muscle cells, stimulating cyclic AMP production. This leads to vasodilation, reduced pulmonary vascular resistance, and inhibition of platelet aggregation, improving blood flow in affected vessels.

The dosing regimen for Iloprost Ratiopharm is individualized and set by the prescribing physician based on the patient’s condition, response, and tolerance. Specific dose and infusion duration are determined by the treating clinician.

Safety data for Iloprost in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and necessary import documentation.

Iloprost is a prostacyclin analog, providing direct vasodilation and antiplatelet effects, whereas endothelin receptor antagonists block vasoconstrictive pathways and phosphodiesterase‑5 inhibitors enhance nitric‑oxide signaling. Choice of therapy depends on disease severity, patient tolerance, and physician assessment.

Iloprost Ratiopharm should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze the solution and avoid shaking the vial, as physical agitation can affect product stability.

Iloprost Ratiopharm is supplied as an intravenous solution that is administered by a healthcare professional through a controlled infusion pump. The infusion rate and duration are set according to the prescribing physician’s instructions.

The most serious risks include severe hypotension, pulmonary edema, and bleeding complications, especially when used with anticoagulants. Patients should be monitored closely for signs of cardiovascular instability and respiratory distress.

Iloprost is contraindicated in patients with active bleeding, severe coronary artery disease, uncontrolled hypotension, or known hypersensitivity to iloprost or any component of the formulation. It should also be used with caution in individuals with pulmonary edema or recent myocardial infarction.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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