Product image of Iloprost Teva (Iloprost) supplied by GNH India

Iloprost Teva

Active Ingredient:
Iloprost
Origin:
EU

Iloprost Teva (Iloprost)

Iloprost, the active ingredient in Iloprost Teva, is a prostacyclin analog presented as a unknown/unknown for intravenous use. It treats pulmonary arterial hypertension and digital ulcers associated with systemic sclerosis.
GNH India supplies Iloprost Teva as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

  • Iloprost acts on the prostacyclin pathway to provide vasodilation and antiplatelet effects in specific vascular conditions.
  • Pulmonary arterial hypertension: improves exercise capacity and hemodynamic parameters.
  • Digital ulcers associated with systemic sclerosis: promotes ulcer healing and reduces the formation of new ulcers.

How It Works

  • Iloprost is a synthetic prostacyclin analog that selectively activates the IP (prostacyclin) receptors on vascular smooth‑muscle cells. Receptor activation increases intracellular cyclic AMP, leading to potent vasodilation, inhibition of platelet aggregation, and antiproliferative effects on the pulmonary arterial wall, thereby lowering pulmonary vascular resistance.

Side Effects

Iloprost may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Flushing
  • Headache
  • Nausea
  • Jaw pain

Serious or Rare Side Effects

  • Severe hypotension
  • Pulmonary edema
  • Bleeding complications

Precautions & Warnings

  • Before initiating Iloprost therapy, clinicians should consider several safety measures.
  • Monitor blood pressure: watch for hypotensive episodes during infusion.
  • Assess bleeding risk: avoid concurrent use with strong anticoagulants unless necessary.
  • Use cautiously after recent myocardial infarction: risk of further cardiac ischemia.
  • Adjust dose in renal or hepatic impairment: impaired clearance may increase exposure.
  • Avoid in uncontrolled infection: systemic vasodilation may worsen sepsis.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Iloprost can interact with other medicines that affect vascular tone or coagulation.

Major Interactions (Avoid)

  • Potent vasodilators (e.g., nitroglycerin): additive hypotension.
  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Endothelin receptor antagonists: potential for excessive blood‑pressure drop.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may enhance vasodilatory effect.
  • Phosphodiesterase inhibitors: possible synergistic hypotension.
  • Non‑steroidal anti‑inflammatory drugs: may affect platelet function.

Frequently Asked Questions

Iloprost Teva is indicated for the treatment of pulmonary arterial hypertension, where it helps lower pulmonary arterial pressure and improve exercise capacity, and for digital ulcers associated with systemic sclerosis, where it promotes ulcer healing and reduces new ulcer formation.

Iloprost is a synthetic prostacyclin analog that activates IP receptors on vascular smooth‑muscle cells, raising cyclic AMP levels. This cascade causes potent vasodilation, inhibits platelet aggregation, and exerts antiproliferative effects on the pulmonary arterial wall, thereby decreasing vascular resistance.

The dosing regimen for Iloprost Teva is individualized. A qualified prescriber determines the infusion rate, duration, and total daily dose based on the patient’s clinical condition, response, and tolerance.

Safety data for Iloprost during pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To order Iloprost Teva, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Iloprost belongs to the prostacyclin analog class, similar to epoprostenol and treprostinil. Compared with epoprostenol, Iloprost has a longer half‑life and can be administered via intermittent intravenous infusion rather than continuous infusion, offering more flexibility but still requiring careful monitoring for hypotension.

Iloprost Teva must be stored refrigerated at 2‑8 °C. Keep the product in its original container, protect it from light, and avoid freezing or shaking the solution. Do not use the product if it has been exposed to temperatures outside this range.

Iloprost Teva is given by intravenous infusion, typically using a controlled infusion pump. The infusion is administered over a set period, often several minutes to an hour, under the supervision of a healthcare professional trained in vascular and pulmonary therapies.

The most serious adverse events include severe hypotension, pulmonary edema, and significant bleeding. Patients should be monitored closely for sudden drops in blood pressure, respiratory distress, or signs of hemorrhage, and treatment should be stopped immediately if these occur.

Iloprost is contraindicated in patients with uncontrolled hypotension, recent myocardial infarction, active severe infection, or known hypersensitivity to prostacyclin analogs. Caution is also advised for individuals with severe hepatic or renal impairment until safety is established.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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