Product image of Iloprost Teva (Iloprost) supplied by GNH India

Iloprost Teva

Active Ingredient:
Iloprost
Origin:
EU

Iloprost Teva (Iloprost)

Iloprost, the active ingredient in Iloprost Teva, is a prostacyclin analog presented as a solution for injection for intravenous or subcutaneous use. It treats pulmonary arterial hypertension in adult patients by promoting vasodilation and inhibiting platelet aggregation. GNH India supplies Iloprost Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

  • Iloprost is a prostacyclin analog used in the management of pulmonary arterial hypertension, a condition characterized by elevated pulmonary vascular resistance.
  • Pulmonary arterial hypertension: improves exercise capacity and delays disease progression.

How It Works

  • Iloprost selectively activates the prostacyclin (IP) receptor on vascular smooth‑muscle cells, leading to increased cyclic AMP levels, which cause potent vasodilation of pulmonary arteries and inhibit platelet aggregation, thereby reducing pulmonary arterial pressure and vascular remodeling.

Side Effects

Iloprost may cause a range of adverse reactions.

Common Side Effects

  • Flushing: transient warmth and redness of the skin.
  • Headache: mild to moderate intensity.
  • Jaw pain: discomfort during chewing.
  • Nausea: occasional upset stomach.
  • Diarrhea: loose stools.
  • Hypotension: mild drop in blood pressure.

Serious or Rare Side Effects

  • Severe hypotension: marked blood pressure fall requiring intervention.
  • Pulmonary edema: fluid accumulation in lungs.
  • Bleeding: increased risk due to antiplatelet effect.
  • Thrombocytopenia: low platelet count.
  • Injection‑site infection: redness or pus at administration site.
  • Chest pain: angina‑like discomfort.

Precautions & Warnings

Before initiating Iloprost therapy, several safety considerations are recommended.

  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Hepatic impairment: use with caution and observe liver enzymes.
  • Pregnancy: risk unknown; avoid unless benefits outweigh risks.
  • Bleeding disorders: assess bleeding risk before treatment.
  • Concomitant vasodilators: monitor blood pressure closely.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Iloprost can interact with other medications, requiring careful management.

Major Interactions (Avoid)

  • Epoprostenol: additive vasodilation may cause severe hypotension.
  • Sildenafil: combined effect can lead to dangerous blood pressure drops.
  • Warfarin: enhanced antiplatelet activity may increase bleeding risk.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: monitor for additive hypotensive effect.
  • Beta‑blockers: may mask signs of low blood pressure.
  • Other prostacyclin analogs: risk of cumulative vasodilatory effects.

Frequently Asked Questions

Iloprost Teva is indicated for the treatment of pulmonary arterial hypertension (PAH). It helps lower elevated pulmonary arterial pressure, improves exercise capacity, and may delay disease progression in adult patients with this serious vascular condition.

Iloprost acts as a selective agonist of the prostacyclin (IP) receptor on vascular smooth‑muscle cells. Activation increases cyclic AMP, causing potent vasodilation of pulmonary arteries and inhibition of platelet aggregation, which together reduce pulmonary arterial pressure.

The dosing regimen for Iloprost is individualized. A qualified prescriber determines the appropriate dose, infusion rate, and duration based on the patient’s clinical status, response, and tolerance. Specific dosing details should be obtained from the treating physician.

Safety data for Iloprost during pregnancy and lactation are limited. The drug should be used only if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To order Iloprost Teva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will provide pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Iloprost is a prostacyclin analog similar to epoprostenol and treprostinil but differs in pharmacokinetics and administration. Compared with epoprostenol, Iloprost has a longer half‑life and can be given subcutaneously, offering more flexible dosing. Treprostinil also provides oral and inhaled forms, whereas Iloprost is available only as an injectable solution.

Iloprost solution for injection must be stored refrigerated at 2‑8 °C. Protect it from light, do not freeze, and avoid shaking the vial. Keep the product in its original packaging until use to maintain stability and sterility.

Iloprost is administered by intravenous or subcutaneous injection, typically as a continuous infusion using an infusion pump. The exact route, rate, and duration are prescribed by the treating physician and should be performed by trained healthcare professionals in an appropriate clinical setting.

Serious adverse events include severe hypotension, pulmonary edema, significant bleeding, thrombocytopenia, and chest pain. Patients should be monitored closely for abrupt drops in blood pressure, respiratory distress, or signs of bleeding, and any such events require immediate medical attention.

Iloprost is contraindicated in patients with known hypersensitivity to iloprost or any component of the formulation. It should also be avoided in individuals with uncontrolled severe hypotension, active bleeding disorders, or recent major surgery unless the prescriber determines that benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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