Product image of Iloprost Waymade (Iloprost) supplied by GNH India

Iloprost Waymade

Active Ingredient:
Iloprost
Origin:
EU

Iloprost Waymade (Iloprost)

Iloprost, the active ingredient in Iloprost Waymade, is a prostacyclin analog presented as an intravenous formulation for intravenous use. It is employed in the management of pulmonary arterial hypertension and in treating digital ulcers associated with systemic sclerosis.

GNH India supplies Iloprost Waymade as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The product complies with EU regulatory standards and is distributed to health‑care institutions across Europe and other regions, ensuring quality and traceability throughout the supply chain.

Manufacturer / TM Owner

Waymade B.V.

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Indications & Clinical Uses

  • Iloprost acts as a prostacyclin analog targeting the pulmonary vascular and microvascular pathways.
  • Pulmonary arterial hypertension: improves hemodynamics and exercise capacity in patients with elevated pulmonary arterial pressure.
  • Digital ulcers associated with systemic sclerosis: promotes ulcer healing and reduces the occurrence of new ulcers.

How It Works

  • Iloprost selectively binds to prostacyclin (PGI2) receptors on vascular smooth‑muscle cells, activating adenylate cyclase and increasing intracellular cyclic‑AMP. The rise in cAMP leads to relaxation of smooth‑muscle, producing potent vasodilation, and simultaneously inhibits platelet aggregation, contributing to improved pulmonary blood flow and microvascular perfusion. The effect is dose‑dependent and reversible, and it does not significantly affect systemic blood pressure at therapeutic concentrations.

Side Effects

Iloprost may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Headache: mild to moderate headache occurring during or after infusion.
  • Flushing: transient warmth and redness of the skin.
  • Nausea: occasional feeling of queasiness.

Serious or Rare Side Effects

  • Severe hypotension: marked blood pressure fall requiring medical intervention.
  • Pulmonary edema: accumulation of fluid in the lungs.
  • Bleeding events: increased risk of hemorrhage, especially with anticoagulants.

Precautions & Warnings

  • When using Iloprost, consider the following precautions to ensure safe therapy.
  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Hepatic impairment: use with caution; liver dysfunction may alter drug metabolism.
  • Pregnancy: safety not established; avoid unless benefit outweighs risk.
  • Concomitant anticoagulants: increased bleeding risk; close monitoring required.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Iloprost can interact with several medications; awareness of these interactions helps optimize patient safety.

Major Interactions (Avoid)

  • Potent vasodilators (e.g., nitroglycerin): may cause severe hypotension.
  • Anticoagulants (e.g., warfarin, heparin): may increase bleeding risk.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs: may diminish antiplatelet effect of Iloprost.
  • Epoprostenol: additive vasodilatory effect may require dose adjustment.
  • Calcium channel blockers: may enhance hypotensive response.

Frequently Asked Questions

Iloprost Waymade is indicated for the treatment of pulmonary arterial hypertension, where it helps lower pulmonary arterial pressure and improve exercise capacity, and for digital ulcers associated with systemic sclerosis, where it promotes ulcer healing and reduces the formation of new ulcers.

Iloprost is a selective prostacyclin (PGI2) receptor agonist. By binding to these receptors on vascular smooth‑muscle cells, it stimulates adenylate cyclase, raises intracellular cyclic‑AMP, and causes vasodilation while also inhibiting platelet aggregation, thereby improving blood flow in the pulmonary circulation and peripheral microvasculature.

The dosing regimen for Iloprost Waymade is individualized. A qualified prescriber determines the appropriate dose, infusion rate, and treatment schedule based on the patient’s clinical condition, response, and tolerance. Specific dosing details should be obtained from the prescribing physician.

Safety data for Iloprost in pregnancy and lactation are limited. The drug should be used only if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics if required), and the necessary import documentation.

Iloprost and other prostacyclin analogues such as epoprostenol share a similar mechanism of vasodilation and platelet inhibition. Iloprost is administered intravenously and has a relatively short half‑life, allowing for controlled infusion, whereas epoprostenol often requires continuous infusion. Choice of therapy depends on clinical response, tolerability, and logistical considerations.

Iloprost Waymade should be stored at 2‑8 °C in a refrigerator. Keep the product in its original packaging, protect it from light, and avoid freezing or shaking the vial. Once removed from refrigeration, use the preparation within the time frame specified in the product labeling.

Iloprost Waymade is given by intravenous infusion. The infusion is typically performed in a clinical setting under medical supervision, with the rate and duration adjusted according to the prescriber’s instructions and the patient’s tolerance. Monitoring of vital signs during and after the infusion is standard practice.

The most serious adverse events include severe hypotension, pulmonary edema, significant bleeding, and allergic reactions such as anaphylaxis. Patients should be monitored closely for sudden drops in blood pressure, respiratory distress, signs of bleeding, or any hypersensitivity symptoms during and after infusion.

Iloprost is contraindicated in patients with known hypersensitivity to iloprost or any component of the formulation, in those with severe uncontrolled hypotension, recent myocardial infarction, or active bleeding disorders. Caution is also advised for individuals with significant hepatic or renal impairment, and the drug should be avoided in pregnancy unless absolutely necessary.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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