Product image of Iloprost Waymade (Iloprost Trometamol) supplied by GNH India

Iloprost Waymade

Active Ingredient:
Iloprost Trometamol
Origin:
EU

Iloprost Waymade (Iloprost Trometamol)

Iloprost, the active ingredient in Iloprost Waymade, is a prostacyclin analog presented as an injection solution for intravenous use. It treats pulmonary arterial hypertension and digital ulcers associated with systemic sclerosis.\n\nGNH India supplies Iloprost Waymade as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Waymade B.V.

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Indications & Clinical Uses

  • Iloprost acts on the prostacyclin pathway to provide vasodilation and anti‑platelet effects in specific vascular disorders.\n\nPulmonary arterial hypertension: improves exercise capacity and lowers pulmonary vascular resistance.\nDigital ulcers associated with systemic sclerosis: promotes ulcer healing and reduces formation of new ulcers.

How It Works

  • Iloprost is a synthetic prostacyclin (PGI2) analog that selectively activates prostacyclin (IP) receptors on vascular smooth‑muscle cells, leading to cyclic AMP accumulation, vasodilation, and inhibition of platelet aggregation, thereby reducing pulmonary arterial pressure and improving microcirculatory flow.

Side Effects

  • Iloprost may cause a range of adverse reactions that vary in frequency and severity.\n\nCommon Side Effects:\n- Flushing or warmth sensation\n- Headache\n- Nausea or vomiting\n- Jaw or tooth pain\n- Hypotension during infusion\n- Infusion‑site pain or irritation\n\nSerious or Rare Side Effects:\n- Severe hypotension or cardiovascular collapse\n- Pulmonary edema\n- Significant bleeding or hemorrhage\n- Thrombocytopenia or platelet dysfunction\n- Cardiac arrhythmias\n- Anaphylactic or severe allergic reactions

Precautions & Warnings

  • Before initiating Iloprost therapy, several safety considerations should be observed.\n\nMonitor blood pressure: watch for hypotension during and after infusion.\nAssess renal function: adjust use in severe renal impairment.\nAvoid in active bleeding: increased risk due to platelet inhibition.\nUse under specialist supervision: intravenous administration requires controlled setting.\nStore at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

  • Iloprost can interact with other medications, requiring careful management.\n\nMajor Interactions (Avoid):\n- Concomitant potent vasodilators: risk of severe hypotension.\n- Anticoagulants or antiplatelet agents: heightened bleeding tendency.\n- Other prostacyclin analogs: additive vasodilatory effects.\n\nModerate Interactions (Monitor Closely):\n- CYP450 inhibitors or inducers: may alter Iloprost plasma levels.\n- Diuretics: potential electrolyte disturbances and blood‑pressure changes.

Frequently Asked Questions

Iloprost Waymade is prescribed for pulmonary arterial hypertension, where it helps lower pulmonary arterial pressure and improve exercise capacity, and for digital ulcers associated with systemic sclerosis, where it promotes ulcer healing and reduces new ulcer formation.

Iloprost is a synthetic prostacyclin analog that binds to IP receptors on vascular smooth‑muscle cells, stimulating cyclic AMP production. This leads to vasodilation, reduced pulmonary vascular resistance, and inhibition of platelet aggregation, which together improve blood flow in affected vessels.

The dose of Iloprost Waymade is individualized and set by the prescribing physician based on the patient’s clinical condition, severity of disease, and response to therapy. Specific dosing regimens are not provided here and should follow the prescriber’s instructions.

Safety data for Iloprost in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed), and import documentation.

Iloprost is a short‑acting prostacyclin analog administered intravenously, offering rapid onset and titratable dosing. Compared with longer‑acting agents such as epoprostenol or treprostinil, Iloprost may require more frequent infusion adjustments but provides flexibility in acute settings and can be used when other prostacyclins are contraindicated.

Iloprost Waymade should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the solution. Keep the product in its original packaging until use to maintain stability and potency.

Iloprost Waymade is given as an intravenous injection or infusion under the supervision of a qualified healthcare professional. The infusion rate and duration are determined by the prescriber, and patients are monitored for blood‑pressure changes and adverse reactions during administration.

Serious risks include severe hypotension, pulmonary edema, significant bleeding, thrombocytopenia, and rare but life‑threatening allergic reactions such as anaphylaxis. Patients should be closely monitored, especially during dose titration and infusion, to detect and manage these events promptly.

Iloprost is contraindicated in patients with active uncontrolled bleeding, severe hypotension, known hypersensitivity to iloprost or any component of the formulation, and in those where prostacyclin therapy is deemed unsafe by the treating physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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