Product image of Iloprost Zentiva (Iloprost) supplied by GNH India

Iloprost Zentiva

Active Ingredient:
Iloprost
Origin:
EU

Iloprost Zentiva (Iloprost)

Iloprost, the active ingredient in Iloprost Zentiva, is a prostacyclin analog presented as an intravenous solution for intravenous administration. Marketed in the European Union, it is used to treat pulmonary arterial hypertension and to improve healing of digital ulcers in patients with systemic sclerosis.

GNH India supplies Iloprost Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, providing quality‑assured product and regulatory support for global distribution through reliable and timely established logistics networks.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

  • Iloprost is a prostacyclin analog used in the management of vascular disorders affecting the pulmonary circulation and peripheral digital vessels.
  • Pulmonary arterial hypertension: reduces pulmonary vascular resistance and improves exercise capacity.
  • Digital ulcers associated with systemic sclerosis: promotes ulcer healing and reduces the formation of new ulcers.

How It Works

  • Iloprost activates prostacyclin (IP) receptors on vascular smooth muscle cells, leading to increased cyclic AMP levels that cause vasodilation, inhibition of platelet aggregation, and antiproliferative effects on the pulmonary arterial wall, thereby improving hemodynamics in affected patients.

Side Effects

Adverse reactions may occur with Iloprost therapy.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness.
  • Nausea: occasional gastrointestinal upset.
  • Jaw pain: discomfort during chewing.
  • Diarrhea: loose stools.
  • Hypotension: mild blood pressure drop.

Serious or Rare Side Effects

  • Pulmonary edema: fluid accumulation in lungs.
  • Severe hypotension: marked blood pressure reduction.
  • Bleeding: increased risk of hemorrhage.
  • Thrombocytopenia: low platelet count.
  • Arrhythmia: irregular heart rhythm.
  • Anaphylaxis: severe allergic reaction.

Precautions & Warnings

  • Iloprost requires careful monitoring and specific handling precautions.
  • Monitor blood pressure: watch for hypotension during infusion.
  • Assess bleeding risk: avoid in patients with active hemorrhage.
  • Evaluate hepatic function: adjust use if liver impairment is present.
  • Use caution in heart failure: may exacerbate fluid overload.
  • Avoid concurrent vasodilators: risk of additive hypotensive effect.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Iloprost can interact with several drug classes, necessitating vigilance.

Major Interactions (Avoid)

  • Other prostacyclin analogs: additive vasodilation.
  • Potent CYP2C9 inhibitors: increased plasma levels.
  • Anticoagulants (e.g., warfarin): heightened bleeding risk.
  • Endothelin receptor antagonists: excessive hypotension.

Moderate Interactions (Monitor Closely)

  • Nitrates: monitor for synergistic blood pressure effects.
  • Calcium channel blockers: observe for enhanced vasodilatory response.
  • Diuretics: watch for electrolyte disturbances.
  • ACE inhibitors: assess for additive hypotension.

Frequently Asked Questions

Iloprost Zentiva is an intravenous prostacyclin analog indicated for the treatment of pulmonary arterial hypertension and for promoting the healing of digital ulcers in patients with systemic sclerosis.

Iloprost activates prostacyclin (IP) receptors on vascular smooth muscle, increasing cyclic AMP, which leads to vasodilation, inhibition of platelet aggregation, and antiproliferative effects that improve pulmonary blood flow and peripheral circulation.

The dosage and infusion schedule of Iloprost Zentiva are determined by the prescribing clinician based on the patient’s condition, response, and tolerance. Specific regimens are not disclosed here.

Safety data for Iloprost in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.

To request Iloprost Zentiva, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Iloprost is a prostacyclin analog that provides vasodilation and antiplatelet effects, whereas endothelin receptor antagonists block vasoconstrictive pathways and phosphodiesterase‑5 inhibitors enhance nitric‑oxide signaling. Choice of therapy depends on disease severity, patient tolerance, and physician assessment.

Iloprost Zentiva must be stored at 2‑8 °C, protected from light, and should not be frozen or shaken. Keep the product in its original packaging until ready for use to maintain stability.

Iloprost Zentiva is given as an intravenous infusion, usually through a peripheral or central line, under the supervision of a healthcare professional who monitors vital signs and infusion parameters.

Serious risks include severe hypotension, pulmonary edema, significant bleeding, thrombocytopenia, and rare anaphylactic reactions. Patients should be monitored closely for these events during and after infusion.

Iloprost is contraindicated in patients with known hypersensitivity to the drug, active uncontrolled bleeding, severe heart failure, or those receiving other prostacyclin analogs without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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