Product image of Iloprost Zentiva Italia (Iloprost) supplied by GNH India

Iloprost Zentiva Italia

Active Ingredient:
Iloprost
Origin:
EU

Iloprost Zentiva Italia (Iloprost)

Iloprost, the active ingredient in Iloprost Zentiva Italia, is a prostacyclin analog presented as a sterile solution for intravenous use. It treats pulmonary arterial hypertension and related vascular conditions in adult patients.
GNH India supplies Iloprost Zentiva Italia as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva Italia S.R.L.

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Indications & Clinical Uses

Iloprost is used in the management of vascular disorders that involve abnormal pulmonary or systemic arterial tone.

  • Pulmonary arterial hypertension: improves exercise capacity and reduces pulmonary vascular resistance.
  • Digital ulcers associated with systemic sclerosis: promotes ulcer healing and reduces new ulcer formation.
  • Peripheral arterial disease: enhances limb perfusion and may alleviate ischemic symptoms.

How It Works

  • Iloprost is a synthetic analog of prostacyclin (PGI2) that binds to prostacyclin (IP) receptors on vascular smooth‑muscle cells, activating adenylate cyclase and increasing intracellular cAMP. The rise in cAMP leads to vasodilation, inhibition of platelet aggregation, and antiproliferative effects on the pulmonary arterial wall, thereby improving hemodynamics in affected patients.

Side Effects

Iloprost may cause a range of adverse reactions, most of which are related to its vasodilatory properties.

Common Side Effects

  • Headache: mild to moderate, often transient.
  • Flushing: warmth and redness of the skin.
  • Nausea: occasional gastrointestinal upset.
  • Jaw pain: discomfort during chewing.
  • Hypotension: drop in blood pressure during infusion.
  • Infusion site pain: local discomfort at the catheter site.

Serious or Rare Side Effects

  • Pulmonary edema: accumulation of fluid in the lungs.
  • Severe hypotension: marked blood pressure reduction requiring intervention.
  • Bleeding: increased risk due to platelet inhibition.
  • Thrombocytopenia: low platelet count.
  • Arrhythmia: abnormal heart rhythm.
  • Myocardial infarction: rare cardiac ischemic event.

Precautions & Warnings

Before initiating Iloprost therapy, clinicians should evaluate several safety considerations.

  • Renal function: assess baseline kidney function and adjust monitoring accordingly.
  • Hepatic impairment: use with caution in patients with liver disease.
  • Concomitant anticoagulants: monitor for enhanced bleeding risk.
  • Pregnancy: avoid unless potential benefits outweigh risks.
  • Hypotension: monitor blood pressure closely during infusion.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Iloprost can interact with other medications that affect vascular tone or coagulation.

Major Interactions (Avoid)

  • Other prostacyclin analogs: additive vasodilatory effect may cause severe hypotension.
  • Potent vasodilators (e.g., nitroglycerin): risk of profound blood pressure drop.
  • Anticoagulants (e.g., warfarin): increased bleeding tendency.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: may enhance hypotensive response.
  • Beta‑blockers: can mask tachycardia signs.
  • Epinephrine: may counteract vasodilatory action.

Frequently Asked Questions

Iloprost Zentiva Italia is indicated for the treatment of pulmonary arterial hypertension, digital ulcers associated with systemic sclerosis, and peripheral arterial disease. In each condition, the drug helps to dilate blood vessels, improve blood flow, and reduce disease‑related symptoms.

Iloprost is a synthetic prostacyclin analog that activates IP receptors on vascular smooth‑muscle cells, raising intracellular cAMP levels. This cascade causes vasodilation, inhibits platelet aggregation, and exerts antiproliferative effects on the arterial wall, thereby improving circulation in affected vascular beds.

The specific dose and infusion schedule of Iloprost Zentiva Italia are determined by the prescribing clinician based on the patient’s condition, severity, and response to therapy. Dosing is individualized and should follow the prescriber’s instructions.

The safety of Iloprost during pregnancy and lactation has not been established. It should only be used if the potential benefits justify the potential risks to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required), and necessary import documentation.

Iloprost belongs to the prostacyclin analog class, offering intravenous delivery and direct vasodilatory effects. Compared with oral endothelin receptor antagonists or phosphodiesterase‑5 inhibitors, Iloprost provides rapid hemodynamic improvement but requires infusion equipment and careful monitoring, making it suitable for patients needing acute or intensive therapy.

Iloprost Zentiva Italia should be stored at 2‑8 °C in a refrigerator. Keep the product in its original packaging, protect it from light, and avoid freezing or shaking the solution to maintain stability.

Iloprost Zentiva Italia is administered intravenously by a healthcare professional. The drug is typically infused over a set period using an infusion pump, with dosage and duration adjusted according to the patient’s clinical response and tolerability.

Serious risks include severe hypotension, pulmonary edema, significant bleeding due to platelet inhibition, thrombocytopenia, arrhythmias, and rare myocardial infarction. Patients should be monitored closely for these events, especially during the initial infusion period.

Iloprost is contraindicated in patients with known hypersensitivity to iloprost or any component of the formulation, those with uncontrolled severe hypotension, and individuals receiving other prostacyclin analogs without medical supervision. Caution is also advised for patients with active bleeding or severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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