Product image of Iloprost Zentiva K.S. (Iloprost) supplied by GNH India

Iloprost Zentiva K.S.

Active Ingredient:
Iloprost
Origin:
EU

Iloprost Zentiva K.S. (Iloprost)

Iloprost, the active ingredient in Iloprost Zentiva K.S., is a prostacyclin analog presented as an inhalation solution for inhalation use. It treats pulmonary arterial hypertension in adult patients by inducing selective vasodilation of the pulmonary arteries, improving exercise capacity and delaying disease progression.

GNH India supplies Iloprost Zentiva K.S. as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company ensures compliance with EU regulatory standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Iloprost acts on the prostacyclin pathway to manage diseases characterized by elevated pulmonary vascular resistance.

  • Pulmonary arterial hypertension: improves functional class, exercise capacity and delays clinical worsening.
  • Chronic thromboembolic pulmonary hypertension: used as adjunct therapy to enhance hemodynamic parameters.
  • Pulmonary hypertension associated with connective‑tissue disease: may be considered to alleviate symptoms and improve quality of life.

How It Works

  • Iloprost is a synthetic prostacyclin (PGI2) receptor agonist. By binding to IP receptors on pulmonary arterial smooth‑muscle cells, it stimulates cyclic AMP formation, leading to potent vasodilation of the pulmonary circulation and inhibition of platelet aggregation, thereby reducing pulmonary arterial pressure and improving blood flow.

Side Effects

Iloprost may cause a range of adverse reactions, most of which are related to its vasodilatory activity.

Common Side Effects

  • Cough or throat irritation
  • Headache
  • Flushing or warmth sensation
  • Nausea or dyspepsia
  • Dizziness or light‑headedness
  • Nasal congestion

Serious or Rare Side Effects

  • Significant hypotension
  • Pulmonary edema
  • Bleeding or hemorrhage
  • Severe chest pain or angina
  • Arrhythmias
  • Anaphylactic or severe allergic reactions

Precautions & Warnings

Before initiating therapy, clinicians should assess individual risk factors and monitor patients closely.

  • Blood pressure monitoring: check for hypotension after each dose.
  • Bleeding risk: evaluate concomitant anticoagulant use and history of hemorrhage.
  • Concomitant vasodilators: avoid or use with caution to prevent additive hypotensive effects.
  • Hepatic impairment: dose adjustment may be required in patients with liver dysfunction.
  • Pregnancy and lactation: safety not established; use only if potential benefit justifies risk.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Iloprost can interact with several medication classes, influencing its safety profile.

Major Interactions (Avoid)

  • Other prostacyclin analogs (e.g., epoprostenol, treprostinil): risk of severe hypotension.
  • Potent vasodilators (e.g., nitroglycerin, hydralazine): additive blood‑pressure lowering effect.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (e.g., warfarin, heparin): increased bleeding tendency.
  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil, tadalafil): may enhance pulmonary vasodilation.
  • Beta‑blockers: may blunt hemodynamic response to Iloprost.

Frequently Asked Questions

Iloprost Zentiva K.S. is an inhalation solution containing the prostacyclin analog Iloprost. It is prescribed for the management of pulmonary arterial hypertension, where it helps lower pulmonary arterial pressure, improve exercise capacity and delay disease progression in adult patients.

Iloprost binds to prostacyclin (IP) receptors on the smooth‑muscle cells of pulmonary arteries. This activation raises cyclic AMP levels, causing selective vasodilation of the pulmonary vasculature and inhibition of platelet aggregation, which together reduce pulmonary arterial pressure and improve blood flow.

The dosing regimen for Iloprost Zentiva K.S. is individualized. A qualified prescriber determines the number of inhalations per day, the volume per inhalation and the treatment schedule based on the patient’s clinical response, severity of disease and tolerance.

Safety data for Iloprost in pregnancy and lactation are limited. The product is classified as having an unknown pregnancy category, so it should only be used when the potential benefit outweighs any possible risk to the fetus or infant. Breastfeeding mothers should consult their physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Iloprost is a short‑acting prostacyclin analog administered by inhalation, offering targeted pulmonary vasodilation with fewer systemic effects compared with intravenous agents like epoprostenol. Compared with oral phosphodiesterase‑5 inhibitors, Iloprost provides rapid onset of action but requires multiple daily inhalations, making it suitable for patients who need immediate hemodynamic improvement.

Iloprost Zentiva K.S. should be stored at room temperature, below 25 °C, in its original packaging. Protect the solution from moisture, direct sunlight and extreme temperatures to maintain stability. Do not freeze the product.

The medication is delivered via a calibrated nebulizer designed for inhalation solutions. Patients inhale the prescribed dose through the mouthpiece, typically multiple times per day as directed by their healthcare provider. Proper device cleaning and technique are essential for consistent dosing.

The most serious adverse events include severe hypotension, pulmonary edema, significant bleeding, and rare anaphylactic reactions. Patients should be monitored for sudden drops in blood pressure, respiratory distress, unexplained bruising or bleeding, and any signs of an allergic response.

Iloprost is contraindicated in patients with known hypersensitivity to Iloprost or any component of the formulation, those with severe hypotension, recent hemoptysis, or uncontrolled bleeding disorders. Caution is also advised for individuals with significant hepatic impairment or those receiving other potent vasodilators.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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