Product image of Iloprost Zentiva Pharma (Iloprost) supplied by GNH India

Iloprost Zentiva Pharma

Active Ingredient:
Iloprost
Origin:
EU

Iloprost Zentiva Pharma (Iloprost)

Iloprost, the active ingredient in Iloprost Zentiva Pharma, is a prostacyclin analog presented as an inhalation solution for inhalation use. It treats pulmonary arterial hypertension and digital ulcers associated with systemic sclerosis in adult patients.

GNH India supplies Iloprost Zentiva Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva Pharma Uk Limited

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Indications & Clinical Uses

  • Iloprost acts on the prostacyclin pathway to provide vasodilation and antiplatelet effects in specific vascular diseases.
  • Pulmonary arterial hypertension: improves exercise capacity and delays disease progression.
  • Digital ulcers associated with systemic sclerosis: promotes ulcer healing and reduces formation of new ulcers.

How It Works

  • Iloprost mimics endogenous prostacyclin (PGI2) by binding to IP receptors on vascular smooth‑muscle cells, activating adenylate cyclase and increasing intracellular cAMP. The rise in cAMP leads to relaxation of pulmonary and systemic arterial smooth muscle, producing vasodilation, and simultaneously inhibits platelet aggregation, contributing to its therapeutic effect in pulmonary hypertension and digital‑ulcer management.

Side Effects

Iloprost may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Cough
  • Throat irritation
  • Headache
  • Flushing

Serious or Rare Side Effects

  • Hypotension
  • Severe bronchospasm
  • Bleeding events

Precautions & Warnings

  • When using Iloprost, clinicians should consider several safety measures.
  • Monitor blood pressure: watch for symptomatic hypotension.
  • Assess bleeding risk: avoid in patients with active hemorrhage.
  • Evaluate pulmonary function: ensure adequate baseline lung capacity.
  • Avoid concomitant potent vasodilators: may amplify hypotensive effects.
  • Use with caution in recent hemoptysis: risk of pulmonary bleeding.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Iloprost can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Other prostacyclin analogs: additive vasodilatory effect.
  • Potent vasodilators (e.g., nitroglycerin): may cause severe hypotension.
  • Anticoagulants (e.g., warfarin): increased bleeding risk.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may blunt antiplatelet action.
  • Calcium channel blockers: potential additive blood‑pressure lowering.
  • Beta‑blockers: may interfere with compensatory heart‑rate response.

Frequently Asked Questions

Iloprost Zentiva Pharma is indicated for the treatment of pulmonary arterial hypertension, where it helps lower pulmonary arterial pressure and improve exercise capacity, and for digital ulcers associated with systemic sclerosis, where it promotes ulcer healing and reduces new ulcer formation.

Iloprost mimics the natural prostacyclin (PGI2) by activating IP receptors on vascular smooth‑muscle cells, raising intracellular cAMP levels. This cascade causes vasodilation of pulmonary and systemic arteries and inhibits platelet aggregation, which together alleviate hypertension and support ulcer healing.

The prescribed dose of Iloprost Zentiva Pharma is individualized by the treating physician based on the patient’s clinical status, severity of disease, and response to therapy. Dosage adjustments are made according to established clinical guidelines and patient tolerance.

Safety data for iloprost in pregnancy and lactation are limited, and the product’s pregnancy category is not established. Healthcare providers should weigh potential benefits against possible risks and consider alternative therapies when treating pregnant or nursing individuals.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and import documentation.

Iloprost belongs to the prostacyclin analog class, offering inhaled delivery that provides targeted pulmonary vasodilation with fewer systemic effects compared with intravenous prostacyclins. Unlike oral endothelin‑receptor antagonists, iloprost can be titrated multiple times daily, allowing rapid adjustment of therapeutic response.

Store Iloprost Zentiva Pharma at room temperature, below 25 °C. Keep the vial in its original packaging, protect it from moisture and direct sunlight, and avoid freezing to maintain product stability.

Iloprost Zentiva Pharma is supplied as an inhalation solution. The patient uses a calibrated nebulizer device to inhale the medication, typically several times per day as directed by the prescriber. Proper inhalation technique and device cleaning are essential for optimal delivery.

Serious risks include significant hypotension, severe bronchospasm, and bleeding complications such as pulmonary hemorrhage. Patients should be monitored closely for sudden drops in blood pressure, respiratory distress, or signs of bleeding, and therapy should be discontinued if these events occur.

Iloprost is contraindicated in patients with known hypersensitivity to iloprost or any component of the formulation, those with active severe bleeding, recent hemoptysis, or uncontrolled hypotension. Caution is also advised for individuals with severe pulmonary infection or unstable cardiovascular conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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