Product image of Ilpez (Itraconazole) supplied by GNH India

Ilpez

Active Ingredient:
Itraconazole
Origin:
EU

Ilpez (Itraconazole)

Itraconazole, the active ingredient in Ilpez, is an azole antifungal presented as an oral formulation for systemic use. It is employed to treat a range of deep‑tissue fungal infections in adult patients, including those caused by Blastomyces, Histoplasma, Aspergillus and dermatophytes.
GNH India supplies Ilpez as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Rafarm Sa.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Ilpez (itraconazole) is used to manage fungal infections that affect various organ systems.

  • Systemic mycoses: provides effective therapy for deep‑seated fungal infections.
  • Blastomycosis: treats infections caused by Blastomyces dermatitidis.
  • Histoplasmosis: clears infections due to Histoplasma capsulatum.
  • Aspergillosis: manages invasive disease caused by Aspergillus species.
  • Dermatophytosis: resolves skin infections caused by dermatophyte fungi.

How It Works

  • Itraconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key component of the ergosterol biosynthesis pathway. By blocking ergosterol production, it disrupts the integrity of the fungal cell membrane, leading to increased permeability and ultimately inhibiting fungal growth and replication.

Side Effects

Adverse reactions to itraconazole may vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: transient cranial discomfort.
  • Diarrhea: loose stools, often self‑limiting.
  • Abdominal pain: cramping or discomfort in the stomach area.
  • Elevated liver enzymes: mild, reversible changes in hepatic function tests.

Serious or Rare Side Effects

  • Hepatotoxicity: significant liver injury requiring monitoring.
  • Congestive heart failure: worsening of pre‑existing cardiac conditions.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Visual disturbances: blurred vision or photophobia.
  • Hematologic abnormalities: neutropenia or thrombocytopenia.

Precautions & Warnings

When prescribing itraconazole, clinicians should consider several safety measures.

  • Liver function: assess baseline hepatic enzymes and monitor periodically.
  • Cardiac status: avoid in patients with uncontrolled heart failure.
  • Drug interactions: review concomitant medications for CYP3A4 substrates or inhibitors.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk.
  • Renal impairment: adjust therapy if severe renal dysfunction is present.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Itraconazole interacts with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may cause toxic itraconazole levels.
  • Certain statins (e.g., simvastatin, lovastatin): increased risk of rhabdomyolysis.
  • Anticoagulants (e.g., warfarin): heightened bleeding risk.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, phenytoin): may reduce itraconazole efficacy.
  • Antacids or H2 blockers: may decrease absorption; separate dosing by at least 2 hours.
  • Digoxin: possible increase in serum concentration; monitor levels.

Frequently Asked Questions

Ilpez contains itraconazole, which is indicated for the treatment of systemic fungal infections such as blastomycosis, histoplasmosis, aspergillosis, and dermatophytosis. It is prescribed for deep‑tissue mycoses where oral antifungal therapy is appropriate.

Itraconazole blocks the fungal enzyme lanosterol 14α‑demethylase, preventing the synthesis of ergosterol, an essential component of fungal cell membranes. This disruption compromises membrane integrity, inhibiting fungal growth and leading to clearance of the infection.

The specific dose of Ilpez is determined by the prescribing clinician based on the type and severity of the infection, patient weight, renal and hepatic function, and other individual factors. Only a qualified healthcare professional should set the dosing regimen.

Itraconazole is generally classified as a pregnancy‑category drug with potential risks to the fetus. It should be used only if the expected benefit outweighs the possible harm. Breastfeeding mothers should consult their physician, as itraconazole may be excreted in breast milk.

To place an order, submit an enquiry on the Ilpez product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other azole antifungals, itraconazole offers a broad spectrum against many systemic fungi and has good tissue penetration. It differs from fluconazole in its activity against certain molds like Aspergillus, but may have a higher potential for drug‑drug interactions due to stronger CYP3A4 inhibition.

Ilpez should be stored at ambient temperature, below 25 °C, in its original container. Keep the product away from moisture, direct sunlight, and extreme heat to maintain its stability and potency throughout its shelf life.

Ilpez is taken orally, usually with food or a full glass of water to enhance absorption. The exact administration schedule, including whether it should be taken with or without meals, is determined by the prescribing clinician.

Serious adverse events can include hepatotoxicity, congestive heart failure exacerbation, severe skin reactions such as Stevens‑Johnson syndrome, and visual disturbances. Patients should be monitored regularly for liver function and cardiac status, and any alarming symptoms should prompt immediate medical evaluation.

Ilpez is contraindicated in patients with known hypersensitivity to itraconazole or any azole antifungal, those with uncontrolled heart failure, and individuals taking strong CYP3A4 inducers that could markedly reduce drug exposure. Clinicians should assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Itraconazole

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT