Product image of Ilpio (Indapamide, Telmisartan) supplied by GNH India

Ilpio

Active Ingredient:
Indapamide, Telmisartan
Origin:
EU

Ilpio (Indapamide, Telmisartan)

Indapamide / Telmisartan, the active ingredient in Ilpio, is a thiazide‑like diuretic and angiotensin II receptor blocker combination presented as an oral tablet for oral use. It is prescribed to lower elevated blood pressure in adult patients with hypertension.

GNH India supplies Ilpio as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support global distribution, offering reliable batch consistency and responsive technical support.

Manufacturer / TM Owner

Pro.Med.Cs Praha A.S.

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Indications & Clinical Uses

Ilpio is indicated for the management of hypertension, a condition characterized by chronically elevated arterial pressure.

  • Essential hypertension: helps achieve target blood pressure levels and reduces cardiovascular risk.
  • Stage 1 hypertension: provides additional blood pressure lowering when monotherapy is insufficient.
  • Stage 2 hypertension: used in combination therapy to attain adequate control in more severe cases.

How It Works

  • Indapamide acts on the distal convoluted tubule, inhibiting sodium‑chloride reabsorption, which promotes diuresis and modest vasodilation. Telmisartan selectively blocks the angiotensin II type‑1 (AT₁) receptor, preventing angiotensin II‑mediated vasoconstriction, aldosterone release, and sympathetic activation. The combined effect reduces intravascular volume and systemic vascular resistance, leading to a sustained decrease in blood pressure.

Side Effects

Like all antihypertensive agents, Ilpio may be associated with adverse reactions that vary in frequency and severity.

Common Side Effects

  • Dizziness or light‑headedness, especially after the first dose.
  • Headache.
  • Fatigue or mild weakness.
  • Increased urination.

Serious or Rare Side Effects

  • Severe electrolyte imbalance (e.g., hyponatremia, hypokalemia).
  • Acute kidney injury or significant rise in serum creatinine.
  • Angio‑edema involving the face, lips, or airway.

Precautions & Warnings

Prior to initiating Ilpio, clinicians should evaluate several safety considerations to minimize risk.

  • Renal function: assess creatinine clearance and adjust therapy if severe impairment is present.
  • Electrolytes: monitor serum potassium and sodium levels, particularly in patients on other diuretics.
  • Hepatic disease: use with caution in patients with liver impairment.
  • Concomitant antihypertensives: avoid excessive blood pressure lowering when combined with other agents.
  • Store at ambient temperature below 25 °C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ilpio can interact with other medicines, altering its antihypertensive effect or increasing the risk of adverse events.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics or supplements: may cause hyperkalaemia.
  • Strong CYP2C9 inhibitors (e.g., fluconazole): can increase telmisartan plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may reduce diuretic efficacy and impair renal function.
  • Lithium: concurrent use can raise lithium levels, risking toxicity.

Frequently Asked Questions

Ilpio is a prescription medication that combines indapamide and telmisartan to treat hypertension. It is used in adult patients whose blood pressure remains elevated despite lifestyle measures, helping to lower both systolic and diastolic pressures and reduce the risk of cardiovascular complications.

Indapamide reduces sodium reabsorption in the distal tubule, promoting diuresis and modest vasodilation. Telmisartan blocks the angiotensin II type‑1 receptor, preventing vasoconstriction and aldosterone‑mediated fluid retention. Together they decrease blood volume and systemic vascular resistance, resulting in a sustained antihypertensive effect.

The dosage of Ilpio is individualized by the prescribing clinician based on the patient’s blood pressure, renal function, and response to therapy. The prescriber determines the appropriate strength, frequency, and any necessary titration, following local prescribing guidelines.

Safety of Ilpio in pregnancy or lactation has not been fully established. Clinicians should weigh potential benefits against risks and consider alternative therapies. Women who are pregnant, planning pregnancy, or breastfeeding should discuss treatment options with their healthcare provider.

To order Ilpio, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ilpio offers a dual mechanism by combining a thiazide‑like diuretic with an angiotensin II receptor blocker, which can provide more consistent blood‑pressure control than monotherapy. Compared with single‑agent ACE inhibitors or calcium‑channel blockers, the combination may reduce the need for additional drugs but requires monitoring for electrolyte changes.

Ilpio should be stored at ambient temperature below 25 °C (77 °F). Keep the tablets in the original packaging, protect them from moisture, heat, and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Ilpio is taken orally, usually once daily, with or without food, as directed by the prescribing physician. Swallow the tablet whole with a glass of water and do not crush or chew it unless specifically instructed.

Serious risks include severe electrolyte disturbances such as hyponatremia or hyperkalaemia, acute kidney injury, and angio‑edema that can affect the airway. Patients should seek immediate medical attention if they experience swelling of the face, lips, tongue, or difficulty breathing.

Ilpio is contraindicated in patients with known hypersensitivity to indapamide, telmisartan, or any component of the formulation. It should also be avoided in individuals with severe renal impairment, hyperkalaemia, or those taking potassium‑sparing diuretics without close monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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