Product image of Ilumetri (Tildrakizumab) supplied by GNH India

Ilumetri

Active Ingredient:
Tildrakizumab
Origin:
EU

Ilumetri (Tildrakizumab)

Tildrakizumab, the active ingredient in Ilumetri, is a interleukin‑23 (IL‑23) inhibitor presented as a solution for subcutaneous injection for subcutaneous use. It is indicated for the treatment of moderate‑to‑severe plaque psoriasis in adult patients.

GNH India supplies Ilumetri as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable cold‑chain logistics for biologic products. These services ensure consistent product integrity from manufacturing to end‑user delivery across global markets.

Manufacturer / TM Owner

Almirall, S.A.

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Indications & Clinical Uses

Ilumetri, an interleukin‑23 inhibitor, is used to manage moderate‑to‑severe plaque psoriasis.

  • Moderate-to-severe plaque psoriasis: Reduces skin lesions and improves quality of life in adult patients.

How It Works

  • Tildrakizumab is a selective humanized IgG1κ monoclonal antibody that binds specifically to the p19 subunit of interleukin‑23. By blocking IL‑23 from interacting with its receptor, the drug inhibits downstream inflammatory signaling pathways that drive the development and persistence of psoriatic plaques.

Side Effects

Common Side Effects

  • Injection site reactions: redness, swelling, or pain at the injection site.
  • Upper respiratory infections: mild cold‑like symptoms.
  • Headache: occasional mild to moderate intensity.
  • Fatigue: feeling unusually tired.
  • Nausea: occasional upset stomach.
  • Diarrhea: loose stools.

Serious or Rare Side Effects

  • Severe allergic reactions: anaphylaxis or angioedema.
  • Serious infections: opportunistic infections such as tuberculosis.
  • Inflammatory bowel disease exacerbation: worsening of Crohn's disease or ulcerative colitis.
  • Malignancies: potential increased risk of certain cancers.
  • Cardiovascular events: rare cases of heart failure or myocardial infarction.

Precautions & Warnings

Before starting Ilumetri, clinicians should consider several safety measures.

  • Screen for active infections: evaluate patients for tuberculosis and other infections before initiation.
  • Monitor for signs of allergic reaction: observe patients during and after injection for rash, swelling, or breathing difficulty.
  • Assess cardiovascular risk: use caution in patients with a history of heart disease.
  • Avoid live vaccines: do not administer live attenuated vaccines during treatment.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Ilumetri may interact with other therapies; awareness helps manage risk.

Major Interactions (Avoid)

  • Live vaccines: contraindicated during treatment.
  • Immunosuppressive agents (e.g., azathioprine, methotrexate): increased risk of serious infection.

Moderate Interactions (Monitor Closely)

  • Systemic corticosteroids: monitor for infection.
  • Antifungal azoles: monitor liver function.
  • Non‑live vaccines: may have reduced efficacy.

Frequently Asked Questions

Ilumetri is indicated for the treatment of moderate‑to‑severe plaque psoriasis in adult patients. It helps reduce the extent and severity of skin lesions, improving patients’ quality of life when conventional therapies are insufficient.

Tildrakizumab is a humanized monoclonal antibody that binds to the p19 subunit of interleukin‑23. By blocking IL‑23 from activating its receptor, the drug interrupts a key inflammatory pathway that drives the formation of psoriatic plaques.

The dosing regimen for Ilumetri is determined by the prescribing healthcare professional based on the patient’s clinical condition, weight, and response. Specific dose amounts and intervals are not disclosed here and should follow the approved prescribing information.

Safety data for tildrakizumab in pregnancy and lactation are limited. The drug should be used only if the potential benefit justifies the potential risk to the fetus or infant, and decisions should be made in consultation with a qualified healthcare provider.

To request Ilumetri, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling), and necessary import documentation.

Ilumetri belongs to the IL‑23 inhibitor class, similar to drugs like guselkumab and risankizumab. All target the IL‑23 pathway but differ in molecular structure, dosing frequency, and clinical trial outcomes. Choice among them depends on physician assessment of efficacy, safety profile, patient preference, and logistical considerations.

Ilumetri must be stored refrigerated at 2‑8 °C. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking. If temporary storage at room temperature is unavoidable, limit exposure to no more than 24 hours.

Ilumetri is supplied as a solution for subcutaneous injection. A healthcare professional administers the injection into the thigh, abdomen, or upper arm according to the prescribed schedule. Patients should be observed for a short period after injection for any immediate reactions.

Serious risks include severe allergic reactions (anaphylaxis), opportunistic infections such as tuberculosis, exacerbation of inflammatory bowel disease, potential malignancies, and rare cardiovascular events. Patients should report any signs of infection, persistent gastrointestinal symptoms, or unusual cardiac symptoms promptly.

Ilumetri is contraindicated in patients with known hypersensitivity to tildrakizumab or any component of the formulation. It should also be avoided in individuals receiving live vaccines or those with active, uncontrolled infections until the infection is resolved.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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