Product image of Iluvien (Fluocinolone Acetonide) supplied by GNH India

Iluvien

Active Ingredient:
Fluocinolone Acetonide
Origin:
EU

Iluvien (Fluocinolone Acetonide)

Fluocinolone Acetonide, the active ingredient in Iluvien, is a corticosteroid presented as a 0.19 mg intravitreal sustained‑release implant for intravitreal use. It treats diabetic macular edema and chronic non‑infectious posterior uveitis in adult patients.

GNH India supplies Iluvien as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Alimera Sciences Europe Limited

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Indications & Clinical Uses

  • Iluvien is indicated for ocular conditions characterized by inflammation and fluid accumulation.
  • Diabetic macular edema: reduces retinal thickness and improves visual acuity.
  • Chronic non‑infectious posterior uveitis: controls intra‑ocular inflammation and helps preserve vision.

How It Works

  • Fluocinolone acetonide binds to glucocorticoid receptors in ocular tissues, modulating gene transcription to suppress pro‑inflammatory cytokines, reduce vascular permeability, and inhibit leukocyte migration. The sustained‑release implant delivers a low, continuous dose directly to the vitreous cavity, maintaining therapeutic concentrations while minimizing systemic exposure.

Side Effects

Iluvien may cause ocular and systemic adverse reactions, which vary in frequency and severity.

Common Side Effects

  • Elevated intraocular pressure
  • Cataract formation or progression
  • Vitreous floaters
  • Mild ocular discomfort or irritation
  • Conjunctival hyperemia
  • Transient blurred vision

Serious or Rare Side Effects

  • Persistent or uncontrolled intraocular pressure leading to glaucoma
  • Endophthalmitis or intraocular infection
  • Retinal detachment or tear
  • Severe cataract requiring surgery
  • Vitreous hemorrhage

Precautions & Warnings

  • Prior to Iluvien implantation, clinicians should assess ocular health and consider patient history.
  • Monitor intraocular pressure: schedule regular pressure checks post‑implant.
  • Assess cataract status: evaluate lens opacity before and after treatment.
  • Avoid in active ocular infection: postpone implantation until infection resolves.
  • Use with caution in patients with glaucoma or a history of steroid‑responsive pressure rise.
  • Do not combine with other intraocular corticosteroid implants.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Iluvien may interact with other ocular or systemic agents that affect intraocular pressure or inflammation.

Major Interactions (Avoid)

  • Concurrent use of other intravitreal corticosteroid implants: risk of additive pressure elevation.
  • Systemic potent CYP3A4 inducers (e.g., rifampin) that could alter steroid metabolism.

Moderate Interactions (Monitor Closely)

  • Topical ocular steroids: monitor intraocular pressure closely.
  • Antiglaucoma medications: adjust dosing if intraocular pressure rises.
  • Anticoagulants: watch for increased risk of intraocular hemorrhage during implantation.

Frequently Asked Questions

Iluvien is approved for the treatment of diabetic macular edema and chronic non‑infectious posterior uveitis. In both conditions, the implant delivers a low‑dose corticosteroid directly to the eye to reduce fluid accumulation, inflammation, and to help preserve or improve visual acuity.

Fluocinolone acetonide activates glucocorticoid receptors in ocular tissues, suppressing inflammatory cytokines and reducing vascular leakage. The sustained‑release implant provides a continuous, low‑level exposure within the vitreous cavity, maintaining anti‑inflammatory activity while limiting systemic exposure.

Iluvien is supplied as a single‑use 0.19 mg intravitreal implant. The exact dosing schedule, including whether a repeat implantation is needed, is determined by the prescribing ophthalmologist based on the patient’s clinical response and disease progression.

The safety of Iluvien in pregnancy and lactation has not been established. Because the implant delivers a corticosteroid directly to the eye, clinicians should weigh potential risks and benefits and consider alternative therapies when treating pregnant or nursing patients.

To request Iluvien, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Iluvien provides a sustained‑release delivery of fluocinolone acetonide for up to 36 months, reducing the need for frequent injections. Compared with short‑acting intravitreal steroids such as triamcinolone or dexamethasone implants, Iluvien offers longer durability but may carry a higher cumulative risk of intraocular pressure rise and cataract formation.

Store Iluvien at ambient temperature, below 25 °C. Keep the implant in its original sealed container, protect it from moisture and direct sunlight, and avoid exposing it to extreme temperatures or mechanical shock.

Iluvien is implanted into the vitreous cavity of the eye by a qualified ophthalmic surgeon using a specialized applicator. The procedure is performed under sterile conditions, typically in an operating room or a designated procedure suite, and does not require systemic administration.

The most serious risks include sustained elevation of intraocular pressure that may lead to glaucoma, development or progression of cataracts requiring surgery, and rare but severe complications such as endophthalmitis, retinal detachment, or vitreous hemorrhage. Patients should be monitored regularly for these events.

Iluvien is contraindicated in patients with active ocular infection, uncontrolled glaucoma, or a known hypersensitivity to fluocinolone acetonide or any component of the implant. It should also be avoided in individuals who have received another intravitreal corticosteroid implant within the same eye.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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