Product image of Iluvien (Fluocinolone Acetonide) supplied by GNH India

Iluvien

Active Ingredient:
Fluocinolone Acetonide
Origin:
EU

Iluvien (Fluocinolone Acetonide)

Fluocinolone Acetonide, the active ingredient in Iluvien, is a corticosteroid presented as a 0.19 mg intravitreal sustained‑release implant for intravitreal injection use. It treats diabetic macular edema and chronic non‑infectious posterior uveitis in adult patients.

GNH India supplies Iluvien as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Alimera Sciences Europe Limited

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Indications & Clinical Uses

  • Iluvien (fluocinolone acetonide) is used for ocular conditions that involve inflammation or fluid accumulation in the posterior segment of the eye.
  • Diabetic macular edema: reduces retinal swelling and improves visual acuity.
  • Chronic non‑infectious posterior uveitis: controls intra‑ocular inflammation and helps preserve vision.

How It Works

  • Fluocinolone acetonide binds intracellular glucocorticoid receptors in ocular tissues, altering gene transcription. This down‑regulates pro‑inflammatory cytokines, decreases vascular permeability, and limits leukocyte infiltration, thereby reducing edema and inflammation within the retina and posterior segment.

Side Effects

Iluvien may cause ocular adverse reactions that vary in frequency and severity.

Common Side Effects

  • Increased intraocular pressure
  • Cataract formation
  • Ocular discomfort or irritation

Serious or Rare Side Effects

  • Endophthalmitis (intraocular infection)
  • Retinal detachment
  • Persistent elevated intraocular pressure requiring surgical intervention

Precautions & Warnings

Prior to implantation, clinicians should assess ocular health and systemic risk factors.

  • Monitor intraocular pressure: schedule regular IOP checks after insertion.
  • Evaluate for cataract development: conduct periodic lens examinations.
  • Avoid in active ocular infection: postpone implantation until infection resolves.
  • Use caution in glaucoma patients: heightened risk of pressure spikes.
  • Assess systemic corticosteroid exposure: consider cumulative effects.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Iluvien may interact with other therapies that influence ocular pressure or immune response.

Major Interactions (Avoid)

  • Concurrent intraocular corticosteroids: additive intraocular pressure elevation.
  • Systemic potent CYP3A4 inhibitors: may increase systemic exposure of fluocinolone acetonide.

Moderate Interactions (Monitor Closely)

  • Systemic immunosuppressants: heightened infection risk.
  • Anticoagulants or antiplatelet agents: increased bleeding risk during injection.
  • Topical non‑steroidal anti‑inflammatory drugs: may mask signs of inflammation.
  • Antiviral agents used for ocular infections: monitor for delayed healing.

Frequently Asked Questions

Iluvien is indicated for the treatment of diabetic macular edema and chronic non‑infectious posterior uveitis. In both conditions it helps reduce retinal swelling and control intra‑ocular inflammation, aiming to preserve or improve visual function.

Fluocinolone acetonide binds to glucocorticoid receptors inside ocular cells, modifying gene transcription. This reduces production of inflammatory cytokines, lowers vascular permeability, and limits leukocyte infiltration, which together decrease fluid accumulation and inflammation in the retina and posterior segment.

The dosing regimen for Iluvien is determined by the prescribing ophthalmologist. The product is a 0.19 mg sustained‑release implant that is inserted once by intravitreal injection; the clinician decides the timing of any repeat implantation based on the patient’s response.

Safety data for Iluvien in pregnancy or lactation are limited, and the product is not classified in a specific pregnancy category. Clinicians should weigh potential benefits against unknown risks and consider alternative therapies when treating pregnant or nursing patients.

To request Iluvien, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Iluvien offers a sustained‑release corticosteroid option that can last up to 36 months, reducing the need for frequent injections. Compared with anti‑VEGF agents, it may be chosen for patients who are non‑responsive to anti‑VEGF therapy or who prefer fewer clinic visits, but it carries a higher risk of intraocular pressure rise and cataract formation.

Iluvien should be stored at 2‑8 °C in a refrigerator. Keep the implant in its original packaging, protect it from light, and avoid freezing or shaking the product. Do not store at ambient temperature.

Iluvien is delivered by a single intravitreal injection performed by a qualified ophthalmic surgeon. The 0.19 mg implant is placed into the vitreous cavity, where it releases fluocinolone acetonide slowly over an extended period.

The most serious risks include endophthalmitis (a severe eye infection), retinal detachment, and persistent elevation of intraocular pressure that may require surgical intervention. Patients should be monitored closely for signs of infection, pressure changes, and retinal integrity after implantation.

Iluvien is contraindicated in patients with active ocular infections, uncontrolled glaucoma, or known hypersensitivity to fluocinolone acetonide or any component of the implant. Caution is also advised for individuals with a history of steroid‑induced intraocular pressure spikes.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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