Product image of Iluvien (Fluocinolone Acetonide) supplied by GNH India

Iluvien

Active Ingredient:
Fluocinolone Acetonide
Origin:
EU

Iluvien (Fluocinolone Acetonide)

Fluocinolone acetonide, the active ingredient in Iluvien, is a glucocorticoid presented as a 0.19 mg intravitreal implant for intravitreal injection use. It is indicated for the treatment of diabetic macular edema in adult patients, helping to reduce retinal swelling and improve visual acuity.

GNH India supplies Iluvien as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, ophthalmology clinics and specialty eye centres worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution. Customers benefit from reliable logistics and post‑delivery support.

Manufacturer / TM Owner

Alimera Sciences Limited

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Indications & Clinical Uses

  • Iluvien (fluocinolone acetonide) is used in the management of retinal vascular disease, specifically diabetic macular edema.
  • Diabetic macular edema (center‑involving): reduces central retinal thickness and stabilises or improves visual acuity.
  • Diabetic macular edema (non‑center‑involving): helps maintain visual function and limits disease progression.
  • Diabetic macular edema refractory to anti‑VEGF therapy: provides a long‑acting corticosteroid alternative for patients with inadequate response.

How It Works

  • Fluocinolone acetonide binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene transcription. This suppresses pro‑inflammatory cytokines, decreases vascular permeability, and inhibits fibrovascular proliferation within the retina, thereby reducing oedema and stabilising the blood‑retinal barrier.

Side Effects

Common Side Effects

  • Increased intraocular pressure.
  • Cataract formation or progression.
  • Ocular pain or discomfort after injection.
  • Vitreous floaters or visual disturbances.
  • Conjunctival haemorrhage.
  • Transient blurred vision.

Serious or Rare Side Effects

  • Endophthalmitis (intraocular infection).
  • Retinal detachment.
  • Persistent elevation of intraocular pressure requiring surgical intervention.
  • Sterile intraocular inflammation.
  • Optic nerve damage.
  • Systemic corticosteroid effects (rare).

Precautions & Warnings

Prior to implantation, assess the patient’s risk for glaucoma and cataract development.

  • Intraocular pressure monitoring: schedule regular IOP checks after insertion.
  • Cataract surveillance: monitor phakic eyes for lens opacity.
  • Avoid use in eyes with active infection or inflammation.
  • Pregnancy and lactation: only use if the potential benefit justifies the potential risk.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Fluocinolone acetonide may interact with other agents that affect ocular pressure or steroid metabolism.

Major Interactions (Avoid)

  • Systemic corticosteroids: additive risk of elevated intraocular pressure.
  • Concurrent intraocular steroids: cumulative steroid load may increase IOP.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise local steroid exposure.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: potential for increased intraocular bleeding post‑injection.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may affect wound healing.
  • Antihypertensive agents: monitor blood pressure if systemic absorption occurs.

Frequently Asked Questions

Iluvien is an intravitreal implant that delivers fluocinolone acetonide directly to the eye. It is approved for the treatment of diabetic macular edema, helping to reduce retinal swelling and preserve or improve vision in affected patients.

Fluocinolone acetonide binds to glucocorticoid receptors inside retinal cells, altering gene transcription. This suppresses inflammatory cytokines, reduces vascular leakage, and inhibits fibrovascular growth, which together decrease macular oedema and stabilise the retinal environment.

The dose of Iluvien is determined by the prescribing ophthalmologist. The product is supplied as a 0.19 mg intravitreal implant that is inserted once and provides sustained drug release for up to 36 months.

Safety of Iluvien in pregnancy or lactation has not been established. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To order Iluvien, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Iluvien offers a sustained‑release corticosteroid option that can be effective when anti‑VEGF agents are insufficient. Unlike repeated injections, the implant provides continuous drug delivery for up to three years, reducing treatment burden but requiring monitoring for steroid‑related side effects such as intraocular pressure rise.

Iluvien must be stored at 2‑8 °C (refrigerated). Keep the implant in its original packaging, protect it from light, and do not freeze or shake. Follow all handling instructions provided by the supplier to maintain product integrity.

Iluvien is administered by a trained ophthalmologist via a single intravitreal injection. The 0.19 mg implant is placed into the vitreous cavity of the eye, where it releases fluocinolone acetonide slowly over several years.

The most serious risks include significant elevation of intraocular pressure that may require surgical intervention, cataract formation, endophthalmitis (eye infection), and rare events such as retinal detachment or optic nerve damage. Regular ophthalmic monitoring is essential.

Iluvien is contraindicated in patients with active ocular infection, uncontrolled glaucoma, or known hypersensitivity to fluocinolone acetonide or any component of the implant. Caution is also advised for patients with a history of steroid‑induced intraocular pressure elevation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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