Product image of Imaduo (Clotrimazole, Hexamidine Diisetionate) supplied by GNH India

Imaduo

Active Ingredient:
Clotrimazole, Hexamidine Diisetionate
Origin:
EU

Imaduo (Clotrimazole, Hexamidine Diisetionate)

Clotrimazole and Hexamidine diisetionate, the active ingredients in Imaduo, are an antifungal and antiseptic presented as a topical formulation for cutaneous use. They are indicated for common superficial fungal infections and work by inhibiting fungal cell membrane synthesis and disrupting microbial membranes. Imaduo is supplied in a ready‑to‑apply preparation suitable for application to the skin.

GNH India supplies Imaduo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoires Bailleul S.A.

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Indications & Clinical Uses

Imaduo combines an antifungal and an antiseptic to treat superficial fungal skin conditions. It is applied directly to the affected area.

  • Tinea corporis: reduces fungal growth and promotes clearance of ring‑shaped lesions.
  • Tinea cruris: alleviates itching and erythema in the groin region.
  • Tinea pedis: controls athlete's foot infection and relieves scaling.
  • Cutaneous candidiasis: eradicates Candida species on the skin and improves symptoms.

How It Works

  • Clotrimazole inhibits the enzyme lanosterol 14‑α‑demethylase, blocking ergosterol synthesis and compromising fungal cell membrane integrity. Hexamidine diisetionate exerts antiseptic activity by disrupting microbial cell membranes and interfering with essential metabolic processes, leading to rapid microbial death. The combined actions provide broad‑spectrum activity against dermatophytes and yeasts on the skin surface.

Side Effects

Topical application of Imaduo may cause local reactions.

Common Side Effects

  • Burning sensation at the application site.
  • Mild itching or pruritus.
  • Redness or erythema.
  • Dryness or peeling of the skin.
  • Stinging or tingling feeling.
  • Local irritation or mild rash.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angio‑edema, anaphylaxis).
  • Extensive blistering or bullous dermatitis.
  • Contact urticaria or widespread rash.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Persistent swelling or edema of the treated area.
  • Secondary bacterial infection of the skin.

Precautions & Warnings

Before using Imaduo, consider the following safety measures.

  • Avoid application on broken or inflamed skin: may increase irritation.
  • Do not apply near eyes, mouth or mucous membranes: risk of accidental ingestion.
  • Discontinue use if severe irritation or allergic reaction occurs: seek medical advice.
  • Pregnant or breastfeeding individuals should consult a healthcare professional before use.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Imaduo may interact with other topical or systemic agents.

Major Interactions (Avoid)

  • Concurrent use with other topical antiseptics or strong irritants: may exacerbate skin irritation.
  • Systemic antifungal therapy (e.g., oral azoles): potential additive antifungal effect leading to increased local toxicity.

Moderate Interactions (Monitor Closely)

  • Co‑application with topical corticosteroids: may mask signs of infection.
  • Use under occlusive dressings: can increase drug absorption and irritation.
  • Alcohol‑based skin products: may cause burning or enhance irritation.
  • Combination with other topical antibiotics: monitor for combined sensitization risk.

Frequently Asked Questions

Imaduo is indicated for superficial fungal skin infections such as tinea corporis (ringworm), tinea cruris (jock itch), tinea pedis (athlete's foot) and cutaneous candidiasis. It is applied directly to the affected skin to reduce fungal growth and relieve associated symptoms.

Clotrimazole inhibits the fungal enzyme lanosterol 14‑α‑demethylase, which is essential for ergosterol synthesis. Without ergosterol, the fungal cell membrane becomes unstable, leading to cell death. This action targets dermatophytes and yeasts responsible for skin infections.

The dosing regimen for Imaduo is determined by the prescribing healthcare professional based on the specific infection, its severity, and patient factors. Typically, a thin layer is applied to the affected area once or twice daily for the prescribed duration.

Safety data for Imaduo in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.

To place an order, submit an enquiry on the Imaduo product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Imaduo combines clotrimazole with hexamidine diisetionate, offering both antifungal and antiseptic activity. This dual mechanism can provide broader antimicrobial coverage compared with single‑agent antifungal creams, potentially reducing secondary bacterial contamination while treating the fungal infection.

Imaduo should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture, heat and direct sunlight to maintain product stability.

Imaduo is a topical preparation applied to clean, dry skin. A thin layer should be spread over the affected area and gently rubbed in. Hands should be washed after application, and the treated skin should not be covered with occlusive dressings unless directed by a clinician.

Serious risks, though rare, include severe allergic reactions such as angio‑edema, anaphylaxis, extensive blistering, Stevens‑Johnson syndrome or toxic epidermal necrolysis. Immediate medical attention is required if any of these symptoms develop.

Imaduo should not be used by individuals with known hypersensitivity to clotrimazole, hexamidine diisetionate, or any excipients in the formulation. It is also contraindicated on severely damaged, ulcerated or infected skin where systemic absorption could be increased.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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