Product image of Imasup (Azathioprine) supplied by GNH India

Imasup

Active Ingredient:
Azathioprine
Origin:
EU

Imasup (Azathioprine)

Azathioprine, the active ingredient in Imasup, is an immunosuppressant presented as an oral formulation for oral use. It is employed to prevent organ rejection after transplantation and to manage autoimmune disorders such as rheumatoid arthritis and inflammatory bowel disease.

GNH India supplies Imasup as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bausch Health Ireland Limited

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Indications & Clinical Uses

Azathioprine is an immunosuppressive agent used in several chronic immune‑mediated conditions.

  • Organ transplantation: helps prevent graft rejection by suppressing the immune response.
  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Inflammatory bowel disease: controls chronic intestinal inflammation in Crohn's disease and ulcerative colitis.

How It Works

  • Azathioprine is an antimetabolite that is converted intracellularly to 6‑mercaptopurine, which interferes with purine nucleotide synthesis. This disruption inhibits DNA replication in rapidly dividing lymphocytes, thereby reducing proliferation of T and B cells and dampening the overall immune response.

Side Effects

Azathioprine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea or vomiting: gastrointestinal discomfort often occurring early in therapy.
  • Leukopenia: reduced white blood cell count, increasing infection risk.
  • Hepatotoxicity: elevated liver enzymes indicating liver stress.
  • Rash or mild skin irritation.

Serious or Rare Side Effects

  • Severe bone marrow suppression: pancytopenia requiring immediate medical attention.
  • Opportunistic infections: due to profound immunosuppression.
  • Increased risk of certain malignancies, such as lymphoma.
  • Pancreatitis: acute abdominal pain with elevated enzymes.

Precautions & Warnings

Before initiating therapy, clinicians should assess baseline laboratory values and monitor regularly.

  • Baseline labs: obtain complete blood count and liver function tests.
  • Infection risk: screen for latent infections (e.g., TB, hepatitis) before treatment.
  • Pregnancy: avoid use unless benefits outweigh risks; discuss with a specialist.
  • Drug interactions: review concomitant medications for potential additive immunosuppression.
  • Renal/hepatic impairment: adjust dose or monitor closely in patients with organ dysfunction.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Azathioprine can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid)

  • Allopurinol or febuxostat: may cause severe bone marrow suppression.
  • Warfarin: increased anticoagulant effect, requiring INR monitoring.
  • Live vaccines: heightened risk of infection; avoid concurrent use.

Moderate Interactions (Monitor Closely)

  • Antacids containing magnesium or aluminum: may reduce absorption.
  • Ribavirin: additive hematologic toxicity.
  • Mycophenolate mofetil: combined immunosuppression may increase infection risk.

Frequently Asked Questions

Imasup contains azathioprine, which is prescribed to prevent organ rejection after transplantation and to manage autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease, including Crohn's disease and ulcerative colitis.

Azathioprine is converted to 6‑mercaptopurine inside cells, where it interferes with purine synthesis. This blocks DNA replication in rapidly dividing lymphocytes, reducing their proliferation and dampening the immune response that drives transplant rejection and autoimmune inflammation.

The dosage of Imasup is individualized by the prescribing clinician based on the specific indication, patient weight, renal and hepatic function, and laboratory monitoring. Patients should follow the dose prescribed by their healthcare professional.

The safety of azathioprine in pregnancy and lactation is not fully established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order Imasup, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Azathioprine is an antimetabolite that differs from calcineurin inhibitors like cyclosporine or tacrolimus, which act on T‑cell activation pathways. Azathioprine offers a distinct mechanism, oral administration, and a different side‑effect profile, making it suitable for patients who need an alternative or adjunctive immunosuppressive strategy.

Imasup should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and heat sources to maintain stability and potency.

Imasup is taken orally, usually with food or a glass of water to reduce gastrointestinal irritation. The exact administration schedule, including timing and whether it is taken once or divided doses, is determined by the prescribing clinician.

Serious risks include severe bone‑marrow suppression leading to pancytopenia, opportunistic infections due to immunosuppression, hepatotoxicity, and an increased long‑term risk of certain cancers such as lymphoma. Patients should be monitored regularly for these complications.

Imasup is contraindicated in individuals with known hypersensitivity to azathioprine or its metabolites, those with severe bone‑marrow failure, active infections, or severe hepatic impairment. Pregnant or breastfeeding women should only use it under strict medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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