Product image of Imatinib Dr. Reddy’s (Imatinib) supplied by GNH India

Imatinib Dr. Reddy’s

Active Ingredient:
Imatinib
Origin:
EU

Imatinib Dr. Reddy’s (Imatinib)

Imatinib, the active ingredient in Imatinib Dr. Reddy’s, is a tyrosine kinase inhibitor presented as an oral tablet for oral use. It is indicated for the treatment of chronic myeloid leukemia, Philadelphia chromosome‑positive acute lymphoblastic leukemia, gastrointestinal stromal tumor, and systemic mastocytosis in appropriate patients.

GNH India supplies Imatinib Dr. Reddy’s as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies, and clinics across multiple regions worldwide. The company adheres to stringent quality standards and provides regulatory support for import and distribution.

Manufacturer / TM Owner

Dr. Reddy’s S.R.L.

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Indications & Clinical Uses

Imatinib acts on abnormal tyrosine‑kinase signaling pathways in certain hematologic and solid tumors.

  • Chronic myeloid leukemia (CML): reduces leukemic cell proliferation and improves survival.
  • Philadelphia chromosome‑positive acute lymphoblastic leukemia (Ph+ ALL): targets the BCR‑ABL fusion protein to achieve remission.
  • Gastrointestinal stromal tumor (GIST): inhibits c‑KIT driven tumor growth.
  • Systemic mastocytosis: blocks KIT signaling to control disease activity.

How It Works

  • Imatinib selectively inhibits the ATP‑binding sites of BCR‑ABL, c‑KIT and platelet‑derived growth factor receptor (PDGFR) tyrosine kinases. By blocking these enzymes, it prevents downstream phosphorylation events that drive uncontrolled cell division, survival, and angiogenesis, thereby suppressing the growth of malignant clones that depend on these pathways. The inhibition is competitive and reversible, leading to cell‑cycle arrest in the G0/G1 phase and promoting apoptosis of the affected cells.

Side Effects

Imatinib may cause a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Nausea and vomiting.
  • Peripheral edema.
  • Muscle cramps or weakness.
  • Fatigue or asthenia.
  • Diarrhea.
  • Skin rash or pruritus.

Serious or Rare Side Effects

  • Neutropenia or severe leukopenia.
  • Hepatotoxicity with elevated transaminases.
  • Cardiac failure or reduced left‑ventricular ejection fraction.
  • Severe skin reactions such as Stevens‑Johnson syndrome.
  • Pulmonary hypertension.
  • Tumor lysis syndrome.

Precautions & Warnings

Patients receiving Imatinib should be monitored for several safety considerations.

  • Monitor blood counts: regular CBC to detect cytopenias.
  • Assess liver function: periodic LFTs for hepatotoxicity.
  • Evaluate cardiac status: baseline and periodic ECG for heart‑failure risk.
  • Avoid use in patients with known hypersensitivity to imatinib.
  • Pregnancy and lactation: use only if potential benefit justifies risk; data limited.
  • Store at ambient temperature: keep below 25 °C, in original container, protect from moisture and light.

Avoid Interactions

Imatinib interacts with several medicines that can alter its effectiveness or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase imatinib exposure.
  • Strong CYP3A4 inducers (e.g., rifampin, phenytoin): may reduce efficacy.
  • Antacids containing aluminum or magnesium: may decrease absorption.
  • QT‑prolonging agents: additive risk of arrhythmia.

Moderate Interactions (Monitor Closely)

  • Warfarin: imatinib may enhance anticoagulant effect; monitor INR.
  • Corticosteroids: may alter imatinib metabolism; adjust dose if needed.
  • Live vaccines: may be less effective; consider timing of administration.

Frequently Asked Questions

Imatinib Dr. Reddy’s is prescribed for chronic myeloid leukemia (CML), Philadelphia chromosome‑positive acute lymphoblastic leukemia (Ph+ ALL), gastrointestinal stromal tumor (GIST), and systemic mastocytosis. In each case the drug targets specific tyrosine‑kinase abnormalities that drive disease progression.

Imatinib binds to the ATP‑binding pocket of BCR‑ABL, c‑KIT and PDGFR tyrosine kinases, preventing phosphorylation of downstream proteins. This blocks signals that promote uncontrolled cell growth, induces cell‑cycle arrest, and triggers apoptosis of malignant cells that rely on these pathways.

The exact dose of Imatinib Dr. Reddy’s is individualized by the prescribing physician based on the specific indication, disease stage, patient weight, renal and hepatic function, and any concomitant therapies. Patients should follow the dosage instructions provided by their healthcare professional.

Safety data for Imatinib in pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To place an order, submit an enquiry on the Imatinib Dr. Reddy’s product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Imatinib was the first targeted tyrosine‑kinase inhibitor approved for CML and remains a standard first‑line option. Newer agents such as dasatinib or nilotinib may offer faster molecular responses in some patients, but Imatinib’s long‑term safety profile and extensive clinical experience make it a widely used and cost‑effective choice.

Imatinib Dr. Reddy’s tablets should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability.

Imatinib Dr. Reddy’s is taken orally, usually as a whole tablet swallowed with water. It can be taken with or without food, but patients should follow any specific instructions from their prescriber regarding timing and whether to avoid certain foods or antacids.

Serious adverse events include severe neutropenia, hepatotoxicity, cardiac dysfunction, pulmonary hypertension, and rare skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored regularly for blood‑count changes, liver enzyme elevations, and cardiac symptoms, and any concerning signs should be reported promptly.

Imatinib is contraindicated in individuals with known hypersensitivity to the drug or any of its excipients. Caution is also advised for patients with pre‑existing severe liver impairment, uncontrolled cardiac disease, or those who are pregnant or breastfeeding unless the benefits clearly outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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