Product image of Imatinib Aenorasis (Imatinib) supplied by GNH India

Imatinib Aenorasis

Active Ingredient:
Imatinib
Origin:
EU

Imatinib Aenorasis (Imatinib)

Imatinib, the active ingredient in Imatinib Aenorasis, is a tyrosine kinase inhibitor presented as an oral tablet for oral use. It treats chronic myeloid leukemia and gastrointestinal stromal tumor in adult patients.\\n\\nGNH India supplies Imatinib Aenorasis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Aenorasis S.A.

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Indications & Clinical Uses

  • Imatinib targets specific tyrosine‑kinase driven cancers and is used in several approved indications.\\n\\nChronic myeloid leukemia (CML): improves survival by inhibiting the BCR‑ABL fusion protein that drives leukemic proliferation.\\nGastrointestinal stromal tumor (GIST): reduces tumor growth by blocking c‑KIT and PDGFR signaling pathways.\\nPhiladelphia chromosome‑positive acute lymphoblastic leukemia (Ph+ ALL): provides targeted therapy that suppresses leukemic cell expansion.

How It Works

  • Imatinib binds to the ATP‑binding pocket of BCR‑ABL, c‑KIT and PDGFR tyrosine kinases, stabilising them in an inactive conformation. This blocks downstream phosphorylation cascades that normally promote cell proliferation, survival and angiogenesis, thereby limiting the growth of malignant cells that depend on these kinases.

Side Effects

  • Adverse reactions may vary in frequency and severity.\\n\\nCommon Side Effects:\\n- Nausea or vomiting\\n- Edema, especially peripheral\\n- Muscle cramps or pain\\n- Fatigue or weakness\\n- Diarrhoea\\n- Skin rash or pruritus\\n\\nSerious or Rare Side Effects:\\n- Neutropenia or severe leukopenia\\n- Hepatotoxicity with elevated transaminases\\n- Cardiac failure or reduced left‑ventricular function\\n- Severe bleeding events\\n- Interstitial lung disease or pneumonitis\\n- Stevens‑Johnson syndrome or toxic epidermal necrolysis

Precautions & Warnings

  • Patients should be monitored closely for safety concerns before and during therapy.\\n\\nMonitor blood counts: watch for neutropenia and anemia.\\nAssess liver function: check transaminases regularly.\\nEvaluate cardiac status: baseline and periodic echocardiograms are advised.\\nAvoid in patients with known hypersensitivity to imatinib or its excipients.\\nUse caution in renal impairment: dose adjustment may be required.\\nStore at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

  • Imatinib may interact with other medicines that affect its metabolism or pharmacodynamics.\\n\\nMajor Interactions (Avoid):\\n- Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): can raise imatinib plasma levels and increase toxicity.\\n- Potent CYP3A4 inducers (e.g., rifampicin, carbamazepine): may lower imatinib exposure and reduce efficacy.\\n\\nModerate Interactions (Monitor Closely):\\n- Proton pump inhibitors (e.g., omeprazole): may modestly affect absorption; monitor therapeutic response.\\n- Anticoagulants (e.g., warfarin): imatinib can alter INR; check coagulation parameters regularly.\\n- Vaccines containing live attenuated virus: immunosuppression may reduce vaccine effectiveness; consider timing.

Frequently Asked Questions

Imatinib Aenorasis is prescribed for chronic myeloid leukemia (CML), gastrointestinal stromal tumor (GIST), and Philadelphia chromosome‑positive acute lymphoblastic leukemia (Ph+ ALL). In each case the drug targets specific tyrosine‑kinase abnormalities that drive malignant cell growth.

Imatinib binds to the ATP‑binding site of BCR‑ABL, c‑KIT and PDGFR tyrosine kinases, locking them in an inactive state. This prevents downstream signaling that would otherwise promote cell proliferation, survival and angiogenesis, thereby inhibiting tumor progression.

The exact dose and dosing schedule are determined by the prescribing clinician based on the patient’s diagnosis, disease stage, renal and hepatic function, and other individual factors. Healthcare professionals should follow approved prescribing information and adjust as needed.

The safety of imatinib in pregnancy and lactation has not been established. It is classified as pregnancy category unknown, and potential risks to the fetus or infant should be weighed against therapeutic benefits. Women of child‑bearing potential should use effective contraception.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Imatinib was the first BCR‑ABL inhibitor and remains a standard of care for CML and GIST. Newer agents such as dasatinib or nilotinib may offer activity against certain resistant mutations, but imatinib retains a well‑characterised safety profile and is often used as first‑line therapy.

Imatinib Aenorasis should be stored at ambient temperature, below 25 °C, in its original packaging to protect from moisture and light. Do not store in a bathroom or near heat sources, and keep the container tightly closed when not in use.

The product is taken orally, usually as a whole tablet swallowed with water. It can be taken with or without food, but patients should follow the prescribing clinician’s instructions regarding timing and any dietary considerations.

Serious adverse events include severe neutropenia, hepatotoxicity,

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GNH India Pharmaceuticals Limited

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Last updated:

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