Product image of Imatinib Stada (Imatinib) supplied by GNH India

Imatinib Stada

Active Ingredient:
Imatinib
Origin:
EU

Imatinib Stada (Imatinib)

Imatinib, the active ingredient in Imatinib Stada, is a tyrosine kinase inhibitor presented as an oral tablet (strength not specified) for systemic use. It is indicated for the treatment of chronic myeloid leukemia and gastrointestinal stromal tumor in adult patients, targeting malignant cell proliferation.

GNH India supplies Imatinib Stada as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, oncology centres, pharmacies and clinics worldwide. The company adheres to EU GMP guidelines and offers a reliable supply chain for oncology therapeutics across multiple continents.

Manufacturer / TM Owner

Stadapharm Gmbh

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Indications & Clinical Uses

Imatinib acts on malignant cells driven by BCR‑ABL and related tyrosine kinases, making it a cornerstone therapy for certain hematologic and solid tumours.

  • Chronic myeloid leukemia (CML): reduces leukemic cell burden and improves long‑term survival.
  • Gastrointestinal stromal tumor (GIST): inhibits tumor growth and delays disease progression.
  • Philadelphia chromosome‑positive acute lymphoblastic leukaemia (Ph+ ALL): contributes to remission when combined with chemotherapy.

How It Works

  • Imatinib selectively binds to the ATP‑binding site of BCR‑ABL, c‑KIT, and PDGFR tyrosine kinases, stabilising the inactive conformation of these enzymes. This inhibition blocks downstream signaling pathways that drive uncontrolled cell proliferation and survival, leading to apoptosis of malignant cells while sparing most normal tissues.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Edema: swelling of the hands, feet, or face.
  • Fatigue: persistent tiredness.
  • Diarrhoea: loose stools.

Serious or Rare Side Effects

  • Neutropenia: significant drop in white blood cells.
  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Cardiac failure: signs of reduced heart function.
  • Severe haemorrhage: unusual bleeding.
  • Pulmonary hypertension: increased pressure in lung arteries.

Precautions & Warnings

Patients and prescribers should observe several safety measures.

  • Monitor blood counts: regular CBC to detect cytopenias.
  • Assess liver function: periodic LFTs for hepatotoxicity.
  • Evaluate cardiac status: baseline and follow‑up cardiac assessments.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Counsel on drug interactions: review concomitant medications.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Imatinib may interact with several co‑administered agents.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase imatinib exposure.
  • Potent CYP3A4 inducers (e.g., rifampin): may reduce therapeutic levels.
  • Antacids containing aluminium or magnesium: can impair absorption.

Moderate Interactions (Monitor Closely)

  • CYP3A4 substrates (e.g., midazolam): may require dose adjustment.
  • Diuretics (e.g., furosemide): monitor electrolytes and renal function.

Frequently Asked Questions

Imatinib Stada is prescribed for chronic myeloid leukemia, gastrointestinal stromal tumor, and Philadelphia chromosome‑positive acute lymphoblastic leukaemia. In each case, the drug targets specific tyrosine kinases that drive malignant cell growth, helping to control disease progression and improve patient outcomes.

Imatinib binds to the ATP‑binding pocket of BCR‑ABL, c‑KIT, and PDGFR tyrosine kinases, locking them in an inactive state. This blocks downstream signaling pathways essential for cancer cell proliferation and survival, leading to apoptosis of the malignant cells while sparing most normal tissues.

The dosage of Imatinib Stada is individualized by the treating physician based on the specific indication, disease stage, patient weight, and tolerability. Only a qualified healthcare professional can determine the appropriate regimen for each patient.

Safety data for Imatinib Stada in pregnancy and lactation are limited. It is generally advised to avoid use unless the potential benefit justifies the potential risk to the fetus or infant. Women of child‑bearing potential should discuss contraception and risk with their physician.

To request Imatinib Stada, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Imatinib was the first BCR‑ABL inhibitor approved and remains a standard of care for several cancers. Compared with newer agents, it has a well‑characterised safety profile and extensive clinical experience, though some newer inhibitors may offer activity against resistant mutations or different dosing schedules.

Imatinib Stada should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture and direct sunlight to maintain its stability throughout its shelf life.

Imatinib Stada is taken orally, usually with a glass of water. It can be swallowed with or without food, but patients should follow the prescribing physician’s instructions regarding timing and any dietary considerations.

Serious risks include severe neutropenia, hepatotoxicity, cardiac failure, pulmonary hypertension, and rare cases of severe bleeding. Patients should be monitored regularly for blood counts, liver function, and cardiac health, and any concerning symptoms should be reported promptly.

Imatinib Stada is contraindicated in individuals with known hypersensitivity to imatinib or any of its excipients. Caution is also advised for patients with pre‑existing severe liver disease, uncontrolled heart failure, or those taking medications that may cause dangerous interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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