Product image of Imatinib Stada (Imatinib) supplied by GNH India

Imatinib Stada

Active Ingredient:
Imatinib
Origin:
EU

Imatinib Stada (Imatinib)

Imatinib, the active ingredient in Imatinib Stada, is a tyrosine kinase inhibitor presented as a tablet for oral use. It is used to treat chronic myeloid leukemia, Philadelphia chromosome‑positive acute lymphoblastic leukemia, and gastrointestinal stromal tumor in appropriate patients.

GNH India supplies Imatinib Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide, ensuring quality and regulatory compliance.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

Imatinib is a targeted tyrosine‑kinase inhibitor used in hematologic and solid‑tumor malignancies.

  • Chronic myeloid leukemia (CML): reduces leukemic cell proliferation and induces remission.
  • Philadelphia chromosome‑positive acute lymphoblastic leukemia (Ph+ ALL): improves survival by targeting the BCR‑ABL fusion protein.
  • Gastrointestinal stromal tumor (GIST): inhibits tumor growth by blocking c‑KIT and PDGFR signaling.

How It Works

  • Imatinib selectively binds to the ATP‑binding pocket of BCR‑ABL, c‑KIT and PDGFR tyrosine kinases, preventing their phosphorylation activity. This blocks downstream proliferative signaling pathways, leading to apoptosis of malignant cells while largely sparing normal tissues.

Side Effects

Imatinib may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: mild gastrointestinal upset.
  • Diarrhea: loose stools.
  • Fatigue: generalized tiredness.
  • Edema: peripheral swelling.

Serious or Rare Side Effects

  • Hepatotoxicity: elevated liver enzymes or hepatitis.
  • Severe neutropenia: marked decrease in neutrophils.
  • Pulmonary arterial hypertension: rare increase in pulmonary pressure.

Precautions & Warnings

When prescribing Imatinib, clinicians should consider several safety precautions to minimize risk.

  • Monitor liver function: perform baseline and periodic hepatic enzyme tests.
  • Assess blood counts: regular CBC to detect neutropenia or thrombocytopenia.
  • Evaluate cardiac status: echocardiogram for patients with pre‑existing heart disease.
  • Review drug interactions: avoid concomitant use with strong CYP3A4 inhibitors.
  • Pregnancy and lactation: contraindicated unless benefits outweigh risks; discuss with obstetrician.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

Avoid Interactions

Imatinib can interact with other medicines, altering its effectiveness or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): increase imatinib plasma levels, risk of toxicity.
  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): reduce imatinib exposure, loss of efficacy.

Moderate Interactions (Monitor Closely)

  • Acid‑reducing agents (e.g., proton pump inhibitors, antacids): may lower absorption, monitor therapeutic response.
  • Anticoagulants (e.g., warfarin): imatinib may enhance anticoagulant effect, check INR.
  • Live attenuated vaccines: potential reduced efficacy, consider timing.

Frequently Asked Questions

Imatinib Stada is prescribed for the treatment of chronic myeloid leukemia, Philadelphia chromosome‑positive acute lymphoblastic leukemia, and gastrointestinal stromal tumor. It works by targeting specific tyrosine kinases that drive the growth of these cancers.

Imatinib inhibits the BCR‑ABL, c‑KIT and PDGFR tyrosine kinases by binding to their ATP‑binding sites. This blocks phosphorylation of downstream proteins, halting proliferative signaling and inducing apoptosis in malignant cells.

The dose of Imatinib Stada is individualized by the prescribing physician based on the specific indication, disease stage, patient weight, renal and hepatic function, and other clinical factors. No standard dose is provided here.

Imatinib is generally contraindicated in pregnancy unless the potential benefit justifies the risk to the fetus. It is also not recommended while breastfeeding because it can be excreted in milk. Consultation with a specialist is essential.

To order, submit an enquiry on the Imatinib Stada product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Imatinib is the first‑generation BCR‑ABL inhibitor and is often used as initial therapy. Second‑generation agents like dasatinib and nilotinib have higher potency and may be chosen for patients with resistance or intolerance to imatinib, but they also have distinct safety profiles.

Store the tablets at ambient temperature, preferably below 25 °C, in the original blister pack or container. Protect from moisture and direct sunlight. Do not refrigerate or freeze the product.

Imatinib Stada is taken orally, usually with a glass of water. It can be taken with or without food, but consistency with regard to meals is recommended to maintain stable absorption.

Serious risks include hepatotoxicity, severe neutropenia, and pulmonary arterial hypertension. Patients should be monitored regularly for liver enzyme elevations, blood count changes, and signs of respiratory distress.

Patients with known hypersensitivity to imatinib or any of its excipients should avoid the drug. It is also contraindicated in individuals with severe hepatic impairment, uncontrolled cardiac disease, or in whom the risk‑benefit ratio is unfavorable.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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