Product image of Imatinib Teva (Imatinib) supplied by GNH India

Imatinib Teva

Active Ingredient:
Imatinib
Origin:
EU

Imatinib Teva (Imatinib)

Imatinib, the active ingredient in Imatinib Teva, is a tyrosine kinase inhibitor presented as an oral formulation for oral use. It treats chronic myeloid leukemia and gastrointestinal stromal tumor in adult patients. It is indicated for patients with Philadelphia chromosome‑positive chronic myeloid leukemia and for those with KIT‑mutated gastrointestinal stromal tumors, providing targeted inhibition of malignant cell proliferation.

GNH India supplies Imatinib Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide, adhering to EU quality standards and providing reliable global logistics.

Manufacturer / TM Owner

Teva Uk Limited

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Indications & Clinical Uses

Imatinib is a tyrosine kinase inhibitor used to target specific oncogenic pathways in certain cancers.

  • Chronic Myeloid Leukemia: achieves durable hematologic and cytogenetic responses in Philadelphia chromosome‑positive disease.
  • Gastrointestinal Stromal Tumor: induces tumor shrinkage and disease control in KIT‑mutated GIST.
  • Dermatofibrosarcoma Protuberans: provides tumor regression by inhibiting PDGFR signaling.

How It Works

  • Imatinib binds to the ATP‑binding site of BCR‑ABL, KIT and PDGFR tyrosine kinases, stabilising them in an inactive conformation. This blocks downstream phosphorylation cascades that drive uncontrolled cell proliferation and survival, thereby suppressing the growth of malignant clones that depend on these oncogenic signals.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Nausea
  • Peripheral edema
  • Fatigue
  • Muscle cramps

Serious or Rare Side Effects

  • Severe neutropenia or leukopenia
  • Hepatotoxicity with elevated transaminases
  • Cardiac failure or reduced left‑ventricular ejection fraction

Precautions & Warnings

Patients should be monitored regularly for safety and efficacy.

  • Monitor blood counts: perform routine complete blood count assessments.
  • Assess liver function: check transaminases and bilirubin before and during therapy.
  • Evaluate cardiac status: monitor for signs of heart failure or reduced ejection fraction.
  • Avoid use in individuals with known hypersensitivity to imatinib or its excipients.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Imatinib may interact with other medicines, altering its effectiveness or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase imatinib exposure.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce imatinib exposure.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., erythromycin, clarithromycin).
  • Warfarin: monitor INR for potential anticoagulation changes.
  • Digoxin: observe serum levels for possible increase.

Frequently Asked Questions

Imatinib Teva is used to treat chronic myeloid leukemia that carries the Philadelphia chromosome and gastrointestinal stromal tumors that have KIT mutations. It may also be employed for dermatofibrosarcoma protuberans, a rare skin cancer, by targeting the same tyrosine kinase pathways.

Imatinib blocks the activity of specific tyrosine kinases such as BCR‑ABL, KIT and PDGFR. By occupying the ATP‑binding pocket of these enzymes, it prevents downstream signaling that drives uncontrolled cell growth, leading to reduced proliferation of malignant cells.

The dose of Imatinib Teva is determined by the prescribing clinician based on the patient’s diagnosis, disease stage, weight, renal and hepatic function, and other individual factors. Only a qualified health professional should set the dosing regimen.

Safety data for Imatinib Teva in pregnancy and lactation are limited. The drug may pose risks to the fetus or infant, and its use is generally avoided unless the potential benefit justifies the risk. Patients should discuss reproductive plans with their healthcare provider.

To request Imatinib Teva, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Imatinib Teva belongs to the first‑generation tyrosine kinase inhibitor class and directly targets BCR‑ABL. Newer agents such as dasatinib or nilotinib are second‑generation inhibitors with broader activity against some resistant mutations, but Imatinib remains a standard first‑line option due to its established efficacy and safety profile.

Imatinib Teva should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and excessive heat to maintain its stability and potency.

Imatinib Teva is taken orally, usually with a glass of water. It can be swallowed with or without food, but patients should follow the specific instructions provided by their prescriber to ensure consistent absorption.

Serious risks include severe neutropenia or leukopenia, which can increase infection risk, hepatotoxicity marked by elevated liver enzymes, and cardiac complications such as reduced left‑ventricular function. Patients should be monitored regularly for these events.

Individuals with known hypersensitivity to imatinib or any of its excipients should avoid the product. Caution is also advised for patients with pre‑existing severe liver impairment, uncontrolled heart failure, or those taking contraindicated strong CYP3A4 modulators.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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