Product image of Imatinib Teva Uk (Imatinib) supplied by GNH India

Imatinib Teva Uk

Active Ingredient:
Imatinib
Origin:
EU

Imatinib Teva Uk (Imatinib)

Imatinib, the active ingredient in Imatinib Teva Uk, is a tyrosine kinase inhibitor presented as a strength/form for oral use. It treats chronic myeloid leukemia and gastrointestinal stromal tumor in adult patients.\n\nGNH India supplies Imatinib Teva Uk as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Teva Uk Limited

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Indications & Clinical Uses

  • Imatinib acts on BCR‑ABL driven malignancies and related tyrosine‑kinase pathways.\n\nChronic Myeloid Leukemia: reduces leukemic cell proliferation and improves long‑term survival.\nGastrointestinal Stromal Tumor: blocks tumor growth and delays disease progression.\nPhiladelphia chromosome‑positive Acute Lymphoblastic Leukemia: induces remission by targeting the BCR‑ABL fusion protein.

How It Works

  • Imatinib selectively inhibits the BCR‑ABL tyrosine kinase, as well as c‑KIT and PDGFR, preventing phosphorylation of downstream signaling proteins. This blockade halts cell‑cycle progression and induces apoptosis in malignant cells that depend on these kinases for proliferation and survival.

Side Effects

  • Imatinib may cause a range of adverse reactions, from mild to severe.\n\nCommon Side Effects:\n- Nausea and vomiting\n- Peripheral edema\n- Muscle cramps or pain\n- Fatigue or weakness\n- Diarrhea\n- Skin rash or itching\n\nSerious or Rare Side Effects:\n- Neutropenia or severe leukopenia\n- Thrombocytopenia\n- Hepatotoxicity with elevated liver enzymes\n- Cardiac failure or reduced left‑ventricular function\n- Severe skin reactions such as Stevens‑Johnson syndrome\n- Pulmonary hypertension or interstitial lung disease

Precautions & Warnings

  • Before initiating therapy, clinicians should assess baseline health status and monitor patients regularly.\n\nMonitor blood counts: perform complete blood count at baseline and periodically.\nAssess liver function: check hepatic enzymes before treatment and during therapy.\nEvaluate cardiac function: perform ECG or echocardiogram in patients with cardiac risk factors.\nAvoid in patients with known hypersensitivity to imatinib or its excipients.\nUse caution in renal impairment: adjust monitoring frequency as needed.\nStore at below 25°C: keep in the original packaging, protect from moisture and light.

Avoid Interactions

  • Imatinib can interact with several medicines that affect its metabolism or increase toxicity.\n\nMajor Interactions (Avoid):\n- Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole) – may raise imatinib levels.\n- Strong CYP3A4 inducers (e.g., rifampin, carbamazepine) – may reduce efficacy.\n- Concomitant use with QT‑prolonging agents – risk of cardiac arrhythmia.\n\nModerate Interactions (Monitor Closely):\n- CYP3A4 substrates (e.g., midazolam, cyclosporine) – may require dose adjustment.\n- Drugs that alter gastric pH (e.g., omeprazole) – may affect absorption.\n- Live vaccines – potential for reduced immune response.

Frequently Asked Questions

Imatinib Teva Uk is prescribed for chronic myeloid leukemia, gastrointestinal stromal tumor, and Philadelphia chromosome‑positive acute lymphoblastic leukemia. In each case the drug targets the BCR‑ABL tyrosine‑kinase pathway that drives malignant cell growth.

Imatinib binds to the ATP‑binding site of BCR‑ABL, c‑KIT and PDGFR tyrosine kinases, preventing their activation. This inhibition stops downstream signaling that normally promotes cell division and survival, leading to apoptosis of the cancer cells that rely on these kinases.

The specific dose of Imatinib Teva Uk is determined by the prescribing physician based on the patient’s diagnosis, disease stage, weight, renal and hepatic function, and response to therapy. Only a qualified healthcare professional should set the dosing regimen.

Safety data for Imatinib in pregnancy and lactation are limited. The drug may pose risks to the fetus and infant, so it should only be used if the potential benefit justifies the potential harm. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their doctor.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Imatinib was the first BCR‑ABL tyrosine‑kinase inhibitor approved for CML and remains a standard first‑line option. Newer agents such as dasatinib or nilotinib may offer faster molecular responses in some patients, but Imatinib’s long‑term safety profile and extensive clinical experience make it a widely used choice.

Imatinib Teva Uk should be stored at temperatures below 25 °C, in its original container, protected from moisture and direct light. Do not store in a bathroom or near a heat source, and keep out of reach of children.

Imatinib Teva Uk is taken orally, usually once daily, with or without food. Tablets should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed by a healthcare professional.

Serious risks include severe neutropenia or thrombocytopenia, hepatotoxicity, cardiac dysfunction, pulmonary hypertension, and rare but life‑threatening skin reactions such as Stevens‑Johnson syndrome. Patients should be monitored regularly for these events, and any concerning symptoms reported promptly.

Patients with known hypersensitivity to imatinib or any of its excipients should avoid the drug. Caution is also advised for individuals with severe hepatic impairment, uncontrolled cardiac disease, or those taking contraindicated strong CYP3A4 inhibitors or inducers without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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