Product image of Imatinib Wockhardt Uk (Imatinib Mesilate) supplied by GNH India

Imatinib Wockhardt Uk

Active Ingredient:
Imatinib Mesilate
Origin:
EU

Imatinib Wockhardt Uk (Imatinib Mesilate)

Imatinib mesylate, the active ingredient in Imatinib Wockhardt Uk, is a tyrosine kinase inhibitor presented as an oral tablet for oral use. It treats chronic myeloid leukemia and gastrointestinal stromal tumor in adult patients.

GNH India supplies Imatinib Wockhardt Uk as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Wockhardt Uk Ltd

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Indications & Clinical Uses

Imatinib mesylate is a tyrosine kinase inhibitor used in hematologic and solid‑tumor indications.

  • Chronic myeloid leukemia (CML): provides disease control by suppressing the malignant BCR‑ABL clone.
  • Gastrointestinal stromal tumor (GIST): induces tumor shrinkage and prolongs progression‑free survival.
  • Philadelphia‑positive acute lymphoblastic leukemia (Ph+ ALL): contributes to remission when combined with chemotherapy.

How It Works

  • Imatinib mesylate binds competitively to the ATP‑binding site of BCR‑ABL, c‑KIT and PDGFR tyrosine kinases, preventing phosphorylation of downstream substrates. This blockade halts proliferative signaling pathways that drive malignant cell growth, leading to apoptosis or cell‑cycle arrest in affected neoplastic cells.

Side Effects

Adverse reactions may occur with any dose of Imatinib.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Edema: peripheral swelling, often of the ankles.
  • Fatigue: reduced energy levels.
  • Diarrhea: loose stools, usually self‑limiting.

Serious or Rare Side Effects

  • Neutropenia: marked reduction in white blood cells.
  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Cardiac failure: signs of reduced cardiac output.
  • Pulmonary hypertension: increased pressure in lung arteries.
  • Severe hemorrhage: unexpected bleeding events.
  • Anaphylaxis: acute allergic reaction requiring emergency care.

Precautions & Warnings

Patients receiving Imatinib should be monitored for safety and efficacy.

  • Blood counts: monitor complete blood count regularly.
  • Liver function: assess hepatic enzymes before and during therapy.
  • Cardiac assessment: evaluate cardiac status in patients with pre‑existing heart disease.
  • Hypersensitivity: discontinue if signs of severe allergic reaction appear.
  • Drug interactions: review concomitant medications for potential CYP3A4 effects.
  • Store at room temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Imatinib may interact with several medicines; careful review is required.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): increase Imatinib exposure.
  • Strong CYP3A4 inducers (e.g., rifampin, phenytoin): reduce therapeutic levels.
  • Antacids containing aluminum or magnesium: may decrease absorption.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect, monitor INR.
  • CYP3A4 substrates (e.g., midazolam): possible increased plasma concentrations.
  • QT‑prolonging agents (e.g., quinidine): monitor cardiac rhythm.

Frequently Asked Questions

Imatinib Wockhardt Uk contains imatinib mesylate, a tyrosine kinase inhibitor indicated for chronic myeloid leukemia, gastrointestinal stromal tumor, and Philadelphia‑positive acute lymphoblastic leukemia. It works by targeting specific kinases that drive the growth of these cancers.

Imatinib mesylate blocks the ATP‑binding sites of BCR‑ABL, c‑KIT and PDGFR tyrosine kinases. By inhibiting these enzymes, it stops downstream signaling that promotes malignant cell proliferation, leading to tumor control or regression.

The dose of Imatinib Wockhardt Uk is individualized by the prescribing physician based on the specific indication, disease stage, patient weight, renal and hepatic function, and other clinical factors. Only a qualified healthcare professional should determine the regimen.

Safety data for imatinib in pregnancy and lactation are limited. It is generally advised to avoid use unless the potential benefit justifies the potential risk to the fetus or infant. Women of child‑bearing potential should discuss contraception with their clinician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Imatinib was the first BCR‑ABL tyrosine kinase inhibitor approved for chronic myeloid leukemia and remains a standard first‑line option. Newer agents such as dasatinib or nilotinib have different potency and side‑effect profiles, but imatinib’s long‑term safety record and extensive clinical experience make it a widely used reference therapy.

Imatinib Wockhardt Uk should be stored at room temperature below 25 °C, in the original packaging, protected from moisture and direct sunlight. Do not store in a refrigerator or freezer unless the label specifically indicates otherwise.

The product is taken orally, usually as a whole tablet with a glass of water. It can be taken with or without food, but patients should follow the specific instructions given by their healthcare provider to maintain consistent drug exposure.

Serious risks include severe neutropenia, hepatotoxicity, cardiac failure, pulmonary hypertension, and rare anaphylactic reactions. Patients should be monitored regularly for blood counts, liver enzymes, cardiac function and any signs of unexpected bleeding or allergic response.

Imatinib is contraindicated in patients with known hypersensitivity to imatinib mesylate or any of the tablet’s excipients. Caution is also advised for individuals with severe hepatic impairment, uncontrolled cardiac disease, or those taking medications that strongly interact with CYP3A4 without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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