Product image of Imazol (Clotrimazole) supplied by GNH India

Imazol

Active Ingredient:
Clotrimazole
Origin:
EU

Imazol (Clotrimazole)

Clotrimazole, the active ingredient in Imazol, is a imidazole antifungal presented as a topical formulation for cutaneous use. It treats superficial fungal infections of the skin such as athlete's foot, ringworm and jock itch in adults and children.
GNH India supplies Imazol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoires Bailleul S.A.

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Indications & Clinical Uses

Imazol (clotrimazole) is used to treat fungal infections of the skin and related conditions.

  • Tinea pedis (athlete's foot): reduces itching, scaling and erythema caused by dermatophyte infection.
  • Tinea corporis (ringworm): clears circular erythematous lesions and prevents spread.
  • Tinea cruris (jock itch): alleviates inflammation and pruritus in the groin area.
  • Candidal skin infections: eliminates yeast overgrowth and resolves erythema and maceration.

How It Works

  • Clotrimazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking ergosterol production, the drug disrupts cell membrane integrity, leading to increased permeability and ultimately fungal cell death. This targeted action limits growth of dermatophytes and yeasts on the skin surface.

Side Effects

Topical clotrimazole is generally well tolerated, but local reactions may occur.

Common Side Effects

  • Burning sensation at the application site.
  • Mild itching or irritation.
  • Redness or mild rash.
  • Dryness or peeling of the skin.
  • Slight stinging during application.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., swelling, hives, difficulty breathing).
  • Contact dermatitis with extensive blistering.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis (very rare).
  • Persistent skin irritation despite discontinuation.
  • Systemic absorption leading to hepatic effects (extremely rare).

Precautions & Warnings

Before using Imazol, consider the following safety measures.

  • Avoid application on broken or inflamed skin: limit use to intact epidermis.
  • Do not use with other topical antifungal agents simultaneously: may increase irritation.
  • Discontinue if severe redness, swelling, or pain develops: seek medical advice.
  • Consult a healthcare professional if infection does not improve within two weeks.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Clotrimazole has limited systemic interactions, but certain combinations may affect safety or efficacy.

Major Interactions (Avoid)

  • Concurrent systemic azole antifungals (e.g., fluconazole) may increase systemic exposure.
  • Use with known hypersensitivity to imidazole compounds.

Moderate Interactions (Monitor Closely)

  • Application with other topical irritants (e.g., harsh soaps) may heighten skin reactions.
  • Use together with potent topical corticosteroids may reduce antifungal effectiveness.
  • Occlusive dressings over treated area can increase drug absorption and irritation risk.

Frequently Asked Questions

Imazol contains clotrimazole and is indicated for superficial fungal infections of the skin, including athlete's foot (tinea pedis), ringworm (tinea corporis), jock itch (tinea cruris) and candidal skin infections. It works by eliminating the fungi that cause these conditions, relieving symptoms such as itching, redness and scaling.

Clotrimazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for producing ergosterol, a key component of the fungal cell membrane. Without ergosterol, the membrane becomes permeable and the fungal cell cannot survive, leading to its death and clearance of the infection.

The dosage of Imazol is determined by the prescribing healthcare professional based on the type and severity of the infection, the patient’s age, and the specific product formulation. Patients should follow the instructions provided on the label or by their clinician and not exceed the recommended amount.

Clotrimazole is generally considered low risk for topical use, but safety data for use during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their healthcare provider before using Imazol to weigh potential benefits against any unknown risks.

To order Imazol, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The team then replies with pricing, availability, shipping details and any necessary import documentation.

Imazol (clotrimazole) belongs to the imidazole class and is effective against a broad range of dermatophytes and yeasts. Compared with allylamine agents such as terbinafine, clotrimazole is typically used for milder infections and offers a favorable safety profile for topical use, though it may require longer treatment durations for some conditions.

Imazol should be stored at room temperature, below 25 °C (77 °F). Keep the product in its original container, protect it from moisture, heat and direct sunlight, and ensure the cap is tightly closed to maintain stability.

Imazol is applied topically to the affected skin area, usually twice daily, after cleaning and drying the skin. A thin layer should be spread over the lesion and a small margin of surrounding healthy skin. Hands should be washed after application unless the hands are the treatment site.

While rare, serious risks include severe allergic reactions such as swelling, hives, or difficulty breathing, and extensive skin reactions like contact dermatitis or Stevens‑Johnson syndrome. If any of these symptoms occur, discontinue use immediately and seek urgent medical attention.

Imazol should not be used by individuals with a known hypersensitivity to clotrimazole, other imidazole antifungals, or any of the product’s excipients. It is also contraindicated on severely damaged, ulcerated or inflamed skin until the underlying condition has healed.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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