Product image of Imazol (Clotrimazole) supplied by GNH India

Imazol

Active Ingredient:
Clotrimazole
Origin:
EU

Imazol (Clotrimazole)

Clotrimazole, the active ingredient in Imazol, is an imidazole antifungal presented as a topical cream for skin use. It treats fungal skin infections such as athlete's foot, ringworm and yeast infections in adults and children.
GNH India supplies Imazol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoires Bailleul S.A.

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Indications & Clinical Uses

Imazol is a topical antifungal that acts on dermatophytes and yeasts causing skin disease.

  • Dermatophyte infections (tinea corporis, tinea cruris, tinea pedis): reduces fungal growth and relieves itching, redness and scaling.
  • Cutaneous candidiasis: eliminates skin yeast overgrowth and clears lesions.
  • Seborrheic dermatitis: controls Malassezia proliferation, decreasing flaking and irritation.

How It Works

  • Clotrimazole inhibits the fungal enzyme lanosterol 14α‑demethylase, blocking the conversion of lanosterol to ergosterol. This disruption impairs the synthesis of ergosterol, an essential component of fungal cell membranes, leading to increased membrane permeability and ultimately fungal cell death.

Side Effects

Topical clotrimazole is generally well tolerated, but local reactions can occur.

Common Side Effects

  • Mild skin irritation or burning at the application site.
  • Itching or pruritus.
  • Redness or erythema.
  • Dryness or peeling of the skin.
  • Stinging sensation.
  • Minor swelling.

Serious or Rare Side Effects

  • Allergic contact dermatitis with rash and blistering.
  • Severe skin reaction such as Stevens‑Johnson syndrome.
  • Extensive swelling or edema.
  • Systemic absorption leading to liver enzyme abnormalities (very rare).
  • Persistent ulceration or infection at the site.
  • Unexplained fever or malaise.

Precautions & Warnings

Before using Imazol, consider the following safety measures.

  • Pregnancy: consult a healthcare professional; safety data are limited.
  • Breastfeeding: avoid application to nipples and discuss with a doctor.
  • Age: not recommended for children under 2 years unless directed by a clinician.
  • Skin condition: do not apply to broken, inflamed or ulcerated skin.
  • Concurrent antifungal therapy: inform the prescriber of any other antifungal products.
  • Store at room temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Clotrimazole may interact with other medications when used concurrently.

Major Interactions (Avoid)

  • Systemic azole antifungals (e.g., fluconazole, itraconazole): may increase systemic exposure.
  • Strong CYP450 inhibitors (e.g., ketoconazole, erythromycin): potential for elevated clotrimazole levels.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may reduce antifungal efficacy.
  • Antifungal shampoos or soaps: concurrent use may increase skin irritation.
  • Alcohol‑based skin products: can enhance local irritation.
  • Other topical agents (e.g., retinoids): monitor for additive skin sensitivity.

Frequently Asked Questions

Imazol is used to treat superficial fungal skin infections such as athlete's foot (tinea pedis), ringworm (tinea corporis), jock itch (tinea cruris), cutaneous candidiasis caused by yeast, and seborrheic dermatitis linked to Malassezia overgrowth.

Clotrimazole blocks the fungal enzyme lanosterol 14α‑demethylase, preventing the synthesis of ergosterol, a key component of fungal cell membranes. Without ergosterol, the membrane becomes permeable, leading to fungal cell death and resolution of the infection.

The dosage of Imazol is determined by the prescribing healthcare professional based on the infection type, severity, patient age and skin area involved. Patients should follow the specific instructions provided on the product label or by their clinician.

Safety data for clotrimazole in pregnancy are limited, so it should be used only if clearly needed and after consulting a healthcare provider. While small amounts are unlikely to affect a nursing infant, application to the breast area should be avoided unless advised by a physician.

To order Imazol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Imazol (clotrimazole) belongs to the imidazole class and offers broad‑spectrum activity against dermatophytes and yeasts. Compared with allylamine agents such as terbinafine, clotrimazole has a slightly slower onset but is effective for a wide range of skin infections and is available over the counter in many regions.

Imazol should be stored at room temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, direct sunlight and excessive heat to maintain stability and potency.

Apply a thin layer of Imazol to the affected skin area, usually twice daily, after washing and drying the region. Continue use for the duration recommended by the prescriber, even if symptoms improve, to ensure complete eradication of the fungus.

Serious risks, though rare, include severe allergic reactions such as contact dermatitis, Stevens‑Johnson syndrome, extensive swelling, or systemic effects like liver enzyme abnormalities. Any signs of severe skin reaction or systemic symptoms should prompt immediate medical attention.

Imazol should not be used on broken, inflamed or ulcerated skin, in individuals with known hypersensitivity to clotrimazole or other imidazole antifungals, and in children under two years of age unless specifically directed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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