Product image of Imazol Duo (Clotrimazole, Hexamidine Diisetionate) supplied by GNH India

Imazol Duo

Active Ingredient:
Clotrimazole, Hexamidine Diisetionate
Origin:
EU

Imazol Duo (Clotrimazole, Hexamidine Diisetionate)

Clotrimazole and Hexamidine diisetionate, the active ingredients in Imazol Duo, are antifungal and antiseptic agents presented as a topical formulation for skin application. They treat fungal infections such as dermatophytosis and candidiasis, as well as superficial bacterial skin infections, in adults and children.

GNH India supplies Imazol Duo as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoires Bailleul S.A.

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Indications & Clinical Uses

Imazol Duo combines an antifungal and an antibacterial agent to treat common superficial skin infections.

  • Dermatophytosis (ringworm): Reduces fungal growth and clears skin lesions.
  • Candidiasis of the skin: Eliminates yeast overgrowth and relieves itching.
  • Superficial bacterial skin infections: Controls bacterial proliferation and promotes healing.

How It Works

  • Clotrimazole inhibits the fungal enzyme lanosterol 14α‑demethylase, blocking ergosterol synthesis and disrupting cell‑membrane formation. Hexamidine diisetionate binds to bacterial cell membranes, interfering with essential cellular processes and exerting broad‑spectrum antibacterial activity. The combined actions provide simultaneous antifungal and antibacterial effects at the site of application.

Side Effects

Topical application of Imazol Duo may be associated with local skin reactions.

Common Side Effects

  • Mild burning or stinging at the application site.
  • Itching or mild irritation.
  • Redness or erythema.
  • Dryness or peeling of the skin.

Serious or Rare Side Effects

  • Severe allergic dermatitis.
  • Contact urticaria.
  • Swelling of the face, lips, or tongue.
  • Blistering or bullous reactions.

Precautions & Warnings

Use Imazol Duo only as directed and monitor for adverse reactions.

  • Avoid use on broken skin: limit application to intact epidermis.
  • Do not apply to eyes or mucous membranes: avoid accidental contact.
  • Discontinue if severe irritation occurs: seek medical advice.
  • Use with caution in patients with known hypersensitivity to clotrimazole or hexamidine: perform a patch test if uncertain.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Imazol Duo may interact with other topical agents or systemic medications that affect skin integrity or microbial flora.

Major Interactions (Avoid)

  • Concurrent use with other topical antifungals or antiseptics: may increase irritation risk.
  • Use with corticosteroid creams: can mask infection signs and delay healing.

Moderate Interactions (Monitor Closely)

  • Systemic antifungal therapy: may alter local drug absorption.
  • Antibiotic therapy affecting skin flora: monitor for reduced efficacy.
  • Use with occlusive dressings: may enhance systemic absorption.

Frequently Asked Questions

Imazol Duo is a topical combination of clotrimazole and hexamidine diisetionate indicated for the treatment of dermatophytosis (ringworm), cutaneous candidiasis, and superficial bacterial skin infections. It is applied directly to the affected skin area to reduce fungal and bacterial growth.

Clotrimazole inhibits the fungal enzyme lanosterol 14α‑demethylase, which is essential for ergosterol synthesis. By blocking ergosterol production, the drug disrupts the integrity of the fungal cell membrane, leading to cell death and resolution of the infection.

The dosage regimen for Imazol Duo is determined by the prescribing healthcare professional based on the type and severity of the infection, patient age, and skin condition. Typically, a thin layer is applied to the affected area once or twice daily as instructed.

Safety data for Imazol Duo in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their healthcare provider before using the product to weigh potential benefits against any unknown risks.

To order Imazol Duo, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Imazol Duo offers a dual mechanism by combining an antifungal (clotrimazole) with an antibacterial (hexamidine diisetionate), providing broader coverage than single‑agent antifungal creams. This can be advantageous when mixed fungal‑bacterial skin infections are suspected, whereas standard antifungal-only products lack antibacterial activity.

Store Imazol Duo at room temperature, preferably below 25 °C. Keep the tube or container tightly closed, protect it from moisture, direct sunlight, and extreme temperatures to maintain product stability and efficacy.

Apply a thin layer of Imazol Duo to clean, dry skin on the affected area. Gently rub it in until it disappears. Follow the prescriber’s instructions regarding frequency and duration of treatment, and avoid covering the area with occlusive dressings unless advised.

Serious risks, although rare, include severe allergic reactions such as contact urticaria, angioedema, or bullous dermatitis. If any signs of swelling, difficulty breathing, or extensive skin blistering occur, discontinue use immediately and seek emergency medical attention.

Imazol Duo should not be used by individuals with a known hypersensitivity to clotrimazole, hexamidine diisetionate, or any excipients in the formulation. It is also contraindicated on extensive broken skin, mucous membranes, or the eyes.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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